Results 61 to 70 of about 110,123 (264)
The Challenge of Targeting Notch in Hematologic Malignancies
Frontiers in Pediatrics, 2014 Notch signaling can play oncogenic and tumor suppressor roles depending on cell type. Hematologic malignancies encompass a wide range of transformed cells, and consequently the roles of Notch are diverse in these diseases. For example Notch is a potent T
Fiorela N Hernandez Tejada +2 more
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A genetic mosaic screen identifies genes modulating Notch signaling in Drosophila. [PDF]
PLoS ONE, 2018 Notch signaling is conserved in most multicellular organisms and plays critical roles during animal development. The core components and major signal transduction mechanism of Notch signaling have been extensively studied.
Luming Ren +6 more
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"Notch-Off": a perspective on the termination of Notch signalling
The International Journal of Developmental Biology, 2009 During Notch mediated lateral inhibition, interacting cells establish or amplify differences in Notch signalling, which are then translated into distinct cell fate decisions according to the developmental context. In recent years, several mechanisms that increase the signalling capacity of interacting cells have been uncovered (reviewed in Bray, 2006 ...
Rita, Fior, Domingos, Henrique
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu +7 more
wiley +1 more source
Journal of the American Society of Nephrology, 2008 The Notch signaling pathway comprises a family of transmembrane receptors, ligands, negative and positive modifiers, and transcription factors with regulatory activity in multiple cellular processes, including cell fate determination, development, differentiation, proliferation, apoptosis ...
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The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina
Cell Reports, 2017 Summary: Notch signaling in neural progenitor cell is triggered by ligands expressed in adjacent cells. To identify the sources of active Notch ligands in the mouse retina, we negatively regulated Notch ligand activity in various neighbors of retinal ...
Taejeong Ha +8 more
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Notch Signaling in Development and Cancer [PDF]
Endocrine Reviews, 2007 Notch is an evolutionarily conserved local cell signaling mechanism that participates in a variety of cellular processes: cell fate specification, differentiation, proliferation, apoptosis, adhesion, epithelial-mesenchymal transition, migration, and angiogenesis. These processes can be subverted in Notch-mediated pathological situations.
Victoria, Bolós +2 more
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Advanced Engineering Materials, EarlyView.Low‐temperature imidization of PEG‐modified polyimide enables fully screen‐printed, roll‐to‐roll fabrication of flexible electrodes on PET substrates, delivering robust mechanical durability and reliable ECG/EMG signal performance for wearable electronics.
Akib Abdullah Khan, Jong‐Hoon Kim
wiley +1 more source
Non-small-cell lung carcinoma: role of the Notch signaling pathway
Lung Cancer: Targets and Therapy, 2015 Levi Barse, Maurizio Bocchetta Department of Pathology, Oncology Institute, Loyola University Chicago, Maywood, IL, USA Abstract: Notch signaling plays a pivotal role during embryogenesis.
Barse L, Bocchetta M
doaj
Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation
Neoplasia: An International Journal for Oncology Research, 2019 Notch pathway signaling is known to promote gastric stem cell proliferation, and constitutive pathway activation induces gastric tumors via mTORC1 activation in mouse genetic models.
Elise S. Hibdon +6 more
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