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The Role of Notch Receptors in Transcriptional Regulation [PDF]
Journal of Cellular Physiology, 2015 Notch signaling has pleiotropic context‐specific functions that have essential roles in many processes, including embryonic development and maintenance and homeostasis of adult tissues. Aberrant Notch signaling (both hyper‐ and hypoactive) is implicated in a number of human developmental disorders and many cancers.
Hongfang, Wang +3 more
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Congenital diseases caused by defective O-glycosylation of Notch receptors [PDF]
, 2018 2018-08The Notch signaling pathway is highly conserved and essential for animal development. It is required for cell differentiation, survival, and proliferation. Regulation of Notch signaling is a crucial process for human health.
Okajima, Tetsuya, Tashima, Yuko
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NOTCH Signaling in T-Cell-Mediated Anti-Tumor Immunity and T-Cell-Based Immunotherapies
Frontiers in Immunology, 2018 The NOTCH (1–4) family of receptors are highly conserved and are critical in regulating many developmental processes and in the maintenance of tissue homeostasis.
Michelle A. Kelliher +1 more
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The NOTCH receptor and its ligands
Trends in Cell Biology, 1997 An intricate interplay of signalling pathways dictates the acquisition of specific cell fates during development. The NOTCH receptor is the central element in a cell-interaction mechanism that controls the fate of a very broad spectrum of precursor cells.
R J, Fleming +2 more
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Notch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros [PDF]
, 2009 Previous studies have highlighted a role for the Notch signalling pathway during pronephrogenesis in the amphibian Xenopus laevis, and in nephron development in the mammalian metanephros, yet a mechanism for this function remains elusive.
Naylor, Richard +7 more
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A toolkit for studying cell surface shedding of diverse transmembrane receptors
eLife, 2019 Proteolysis of transmembrane receptors is a critical cellular communication mechanism dysregulated in disease, yet decoding proteolytic regulation mechanisms of hundreds of shed receptors is hindered by difficulties controlling stimuli and unknown fates ...
Amanda N Hayward +2 more
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NOTCH activation promotes glycosyltransferase expression in human myeloid leukemia cells
Hematology Reports, 2018 NOTCH signaling diversely regulates the growth of acute myeloid leukemia (AML) cells. It is known that glycosylation of NOTCH receptors modulates NOTCH activation. However, little is known about glycosylation of NOTCH in AML cells.
Shichun Wang +4 more
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Surgical and Experimental Pathology, 2020 Background The Notch signaling pathway and its modulators are directly related to growth, verticalization and metastasis in melanoma, being a possible therapeutic target for the treatment of this type of cancer.
Lorena Dal Collina Sangiuliano +4 more
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Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]
, 2006 A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G +14 more
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Nature Communications, 2021 Although activated Notch receptors have been associated with chemoresistance in cancer, the role of specific Notch ligands remain elusive. Here, the authors show that in breast cells the Notch ligand DLL1 is expressed in cells with a cancer stem cell ...
Sushil Kumar +12 more
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