Results 21 to 30 of about 2,850,125 (303)
Frontiers in Genetics, 2023 Background: Notch receptors (Notch 1/2/3/4), the critical effectors of the Notch pathway, participate in the tumorigenesis and progression of many malignancies.
Zong-Qing Zheng +6 more
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Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions
Biomolecules, 2021 The 100th anniversary of Notch discovery in Drosophila has recently passed. The Notch is evolutionarily conserved from Drosophila to humans. The discovery of human-specific Notch genes has led to a better understanding of Notch signaling in development ...
Wataru Saiki +3 more
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Significant Roles of Notch O-Glycosylation in Cancer
Molecules, 2022 Notch signaling, which was initially identified in Drosophila wing morphogenesis, plays pivotal roles in cell development and differentiation. Optimal Notch pathway activity is essential for normal development and dysregulation of Notch signaling leads ...
Weiwei Wang +2 more
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Notch signaling pathway: architecture, disease, and therapeutics
Signal Transduction and Targeted Therapy, 2022 The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription
Binghan Zhou +6 more
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Therapeutic antibody targeting of individual Notch receptors [PDF]
Nature, 2010 The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to regulate cell fate and growth. Ligand binding triggers a conformational change in the receptor negative regulatory region (NRR) that enables ADAM protease cleavage at a juxtamembrane site that ...
Yan Wu +23 more
semanticscholar +3 more sources
Human Ligands of the Notch Receptor [PDF]
The American Journal of Pathology, 1999 During development, the Notch signaling pathway is essential for the appropriate differentiation of many cell types in organisms across the phylogenetic scale, including humans. Notch signaling is also implicated in human diseases, including a leukemia and two hereditary syndromes known as Alagille and CADASIL.
G E, Gray +9 more
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Cell Reports, 2023 Summary: The Notch signaling pathway controls cell growth, differentiation, and fate decisions. Dysregulation of Notch signaling has been linked to various human diseases.
Weixiang Bian +5 more
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Infectious Microbes & Diseases, 2021 . Pattern-recognition receptors, such as toll-like receptors (TLRs), detect a wide range of microbial products and initiate innate immune responses leading to the production of inflammatory mediators.
Yuna Zhao +7 more
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Notch receptor and Notch ligand expression in developing avian cartilage [PDF]
Journal of Anatomy, 2009 AbstractThe development of limb cartilage involves complex signalling pathways allowing the formation of distinct segments of cartilage that are maintained in the fully developed joint. In this study, we investigated the Notch signalling pathway and its role in cartilage development.
Rebecca, Williams +4 more
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NOTCH Receptors and DLK Proteins Enhance Brown Adipogenesis in Mesenchymal C3H10T1/2 Cells
Cells, 2020 The NOTCH family of receptors and ligands is involved in numerous cell differentiation processes, including adipogenesis. We recently showed that overexpression of each of the four NOTCH receptors in 3T3-L1 preadipocytes enhances adipogenesis and ...
María-Milagros Rodríguez-Cano +7 more
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