Notch3 in Development, Health and Disease [PDF]
Biomolecules, 2020 Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control cell fate in many developmental and adult tissue contexts.
Samira Hosseini-Alghaderi +1 more
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Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. [PDF]
PLoS Genetics, 2014 The Notch3 signaling pathway is thought to play a critical role in cancer development, as evidenced by the Notch3 amplification and rearrangement observed in human cancers.
Jin-Gyoung Jung +7 more
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Biochemical characterization and cellular effects of CADASIL mutants of NOTCH3. [PDF]
PLoS ONE, 2012 Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the best understood cause of dominantly inherited stroke and results from NOTCH3 mutations that lead to NOTCH3 protein accumulation and selective ...
He Meng +6 more
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Clinical and neuroradiological spectrum of biallelic variants in NOTCH3 [PDF]
EBioMedicineNOTCH3 encodes a transmembrane receptor critical for vascular smooth muscle cell function. NOTCH3 variants are the leading cause of hereditary cerebral small vessel disease (SVD). While monoallelic cysteine-involving missense variants in NOTCH3 are well-studied in cerebral autosomal dominant arteriopathy with subcortical infarcts and ...
Fatema Al-Amrani +2 more
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Cysteine-reactive mitigators of small vessel disease-related NOTCH3 mutants [PDF]
Scientific ReportsPathogenic alterations in NOTCH3 cause CADASIL, an accelerated and currently untreatable form of cerebrovascular disease. CADASIL mutant NOTCH3, which frequently harbors abnormalities in EGF repeat cysteine number, adopt disulfide dependent abnormal ...
Naw May Pearl Cartee +3 more
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Jagged-mediated lateral induction patterns Notch3 signaling within adult neural stem cell populations [PDF]
Nature CommunicationsIn the adult brain, Notch3 signaling promotes neural stem cell (NSC) quiescence and stemness. It remains unknown how Notch3 signaling levels are controlled and relate to these NSC decisions.
Sara Ortica +5 more
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Reduced SUMOylation impairs NOTCH3 signaling and cell survival in the pathogenesis of CADASIL [PDF]
Cell Communication and SignalingCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vessel disease caused by NOTCH3 mutation.
Lijun Long +5 more
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Necessity of Notch3 signaling in myofiber maturation in a pluripotent stem cell transplant model [PDF]
Skeletal MuscleBackground Pluripotent stem cell-derived myogenic progenitors change from an embryonic to a postnatal molecular signature upon engrafting as satellite cells, which coincides with upregulation of Notch3.
Aline M. S. Yamashita +10 more
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Use of antisense oligonucleotides to target Notch3 in skeletal cells.
PLoS ONE, 2022 Notch receptors are determinants of cell fate and function, and play an important role in the regulation of bone development and skeletal remodeling. Lateral Meningocele Syndrome (LMS) is a monogenic disorder associated with NOTCH3 pathogenic variants ...
Ernesto Canalis +4 more
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Detection of Vascular Notch3 Deposits in Unfixed Frozen Skin Biopsy Sample in CADASIL
Frontiers in Neurology, 2022 This study aimed to evaluate the utility of immunohistochemical staining of vascular Notch3 deposits in biopsied unfixed frozen skin samples from patients with suspected cerebral autosomal dominant arteriopathy with subcortical infarcts and ...
Akihiko Ueda +8 more
doaj +1 more source