Results 1 to 10 of about 23,019 (220)

Patient with CADASIL – a diagnostic challenge

Annales Academiae Medicae Silesiensis, 2023
INTRODUCTION: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetically determined and hereditary cerebral small vessel disease caused by mutations in the NOTCH3 gene.
Julia Węgrzynek, Agnieszka Tomaszewska, Angelika Wawrzkiewicz-Witkowska   +2 more
doaj   +1 more source

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation [PDF]

, 2018
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Alve, S, Balistreri, G, Gramolelli, S, Hautaniemi, S, Icay, K, Ivaska, J, Lehti, K, Niiranen, O, Ojala, PM, Paatero, I, Pekkonen, P, Perälä, N, Repo, P, Saharinen, P, Taiwo, A, Tatti-Bugaeva, O, Tuohinto, K, Zinovkina, N   +17 more
core   +1 more source

Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide. [PDF]

, 2015
BackgroundTemozolomide (TMZ) is an oral DNA-alkylating agent used for treating patients with glioblastoma. However, therapeutic benefits of TMZ can be compromised by the expression of O6-methylguanine methyltransferase (MGMT) in tumor tissue.
Bui, Yvonne, Cloughesy, Timothy F, Hong, Irene, Lai, Albert, Liau, Linda M, McBride, William H, Menjivar, Jimmy C, Nelson, Stanley F, Stream, Alexandra, Tso, Cho-Lea, Tso, Jonathan L, Yamada, Kazunari, Yang, Shuai, Yong, William H, Zhang, Yibei   +14 more
core   +2 more sources

Lung tumorspheres as a drug screening platform against cancer stem cells [PDF]

, 2019
Treatment resistance and metastasis are linked to cancer stem cells (CSCs). This population represents a promising target, but remains unexplored in lung cancer.
Amado, H., Blasco, Ana, Calabuig, Silvia, Camps, C., Durendez-Saez, Elena, Escorihuela, Eva, Herreros Pomares, Alejandro, Jantus Lewintre, Eloisa, Murga, Juan, Navarro, A., Sampedro, C., Torres, Susana, Zhang, F.   +12 more
core   +1 more source

RANBP1 Regulates NOTCH3-Mediated Autophagy in High Glucose-Induced Vascular Smooth Muscle Cells

Frontiers in Bioscience-Landmark
Background: Vascular smooth muscle cells(VSMCs) phenotypic switching under hyperglycemic conditions accelerates atherosclerotic progression.
Zhong-jiao Xu, Jian Xu, Wen-jing Lei, Xiang Wang, Qi-lin Zou, Lin-chun Lv, Chong Liu, Wu-ming Hu, Yi-jia Xiang, Jia-yi Shen, Tie-min Wei, Chun-lai Zeng   +11 more
doaj   +1 more source

RET mutation and increased angiogenesis in medullary thyroid carcinomas [PDF]

, 2016
Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis.
Acquaviva, Giorgia, Boichard, Amélie, Casadei, Gian Piero, Checquolo, Saula, Colato, Chiara, de Biase, Dario, Durante, Cosimo, Ferdeghini, Marco, Filetti, Sebastiano, Pecce, Valeria, Rhoden, Kerry, Rosignolo, Francesca, Russo, Diego, Sponziello, Marialuisa, Tallini, Giovanni, Verrienti, Antonella, Visani, Michela   +16 more
core   +1 more source

notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish

Disease Models & Mechanisms, 2013
SUMMARY Mutations in the human NOTCH3 gene cause CADASIL syndrome (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy).
Andreas Zaucker, Sara Mercurio, Nitzan Sternheim, William S. Talbot, Florence L. Marlow   +4 more
doaj   +1 more source

The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients

Open Medicine, 2022
ASAP3 is involved in a variety of biological activities, including cancer progression in humans. In adult glioma, we explore the effects of ASAP3 and NOTCH3 and their relationships on prognosis.
Su Li-ping, Ji Min, Liu Li, Sang Wei, Xue Jing, Wang Bo, Pu Hong-Wei, Zhang Wei   +7 more
doaj   +1 more source

Dynamics of notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle [PDF]

, 2013
Articles in International JournalsThe transcription and expression patterns of Notch pathway components (Notch 1–3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key ...
A Fischer, a Hess R, a Hess R, Alexandre Trindade, António Duarte, AR Bellvi, B Bielesz, BR Nebel, C Afonso, C Firlit, C Zeng, Daniel Murta, Domingos Henrique, E Assa-Kunik, E Silva, E Silva, EF OAKBERG, EJ Lambie, EJ Ward, Elisabete Silva, F Batista, G Dirami, H Takanaga, H-T Cheng, HB Ariyaratne, I Sörensen, J Boucher, J Kimble, J Lu, J Zavadil, Jean-Marc A. Lobaccaro, K Hasegawa, K Shimizu, KL Hahn, LT Krebs, Luís Lopes-da-Costa, M Lupien, M Morimoto, M Rahmana, M Stahl, M-C Hofmann, Marta Batista, Mruk Wong, EWP Dolores D, R Bultje, R Habert, RM Das, S Artavanis-Tsakonas, S Kimmins, S Mori, SS Saravanamuthu, T Borggrefe, T DeFalco, T Hayashi, T Hayashi, T Kitamoto, TX Garcia, V Von Schönfeldt, X Feng, X Song, Y Clermont, Y Kitadate, Y Niwa, Y Wang, Z Sahin, Z Yuan   +64 more
core   +13 more sources

Association of NOTCH3 Gene Polymorphisms with Ischemic Stroke and Its Subtypes: A Meta-Analysis

Medicina, 2019
Background and objectives: NOTCH3 gene variations play a significant role in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Loo Keat Wei, Lyn R. Griffiths, Irene Looi, Cheah Wee Kooi   +3 more
doaj   +1 more source