Notch3 in Development, Health and Disease [PDF]
Biomolecules, 2020 Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control cell fate in many developmental and adult tissue contexts.
Martin Baron
exaly +8 more sources
Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. [PDF]
PLoS Genetics, 2014 The Notch3 signaling pathway is thought to play a critical role in cancer development, as evidenced by the Notch3 amplification and rearrangement observed in human cancers.
Jin-Gyoung Jung +7 more
doaj +5 more sources
Biochemical characterization and cellular effects of CADASIL mutants of NOTCH3. [PDF]
PLoS ONE, 2012 Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the best understood cause of dominantly inherited stroke and results from NOTCH3 mutations that lead to NOTCH3 protein accumulation and selective ...
He Meng +6 more
doaj +2 more sources
Analysis of Notch1 and Notch3 Signaling Pathway Components in Benign Prostatic Hyperplasia and Prostate Cancer Patients. [PDF]
J Clin Lab AnalThis study evaluates the association between Notch1 and Notch3 genetic variations and serum protein levels in patients with benign prostatic hyperplasia and prostate cancer. While genetic variations showed no significant link to disease risk, serum protein levels were significantly lower in prostate cancer and metastatic groups compared to healthy ...
Yagci E +4 more
europepmc +2 more sources
Notch3/4 Knockdown Inhibits Colon Adenocarcinoma Progression by Suppressing Tumor Cell Activity and Orchestrating VEGFA‐Dependent Tumor Immune Microenvironment [PDF]
Cancer MedicineBackground Colon adenocarcinoma (COAD) is a prevalent gastrointestinal malignancy characterized by dysregulation of multiple cellular signaling pathways, including the Notch pathway.
Wei Liu +5 more
doaj +2 more sources
Cysteine-reactive mitigators of small vessel disease-related NOTCH3 mutants [PDF]
Scientific ReportsPathogenic alterations in NOTCH3 cause CADASIL, an accelerated and currently untreatable form of cerebrovascular disease. CADASIL mutant NOTCH3, which frequently harbors abnormalities in EGF repeat cysteine number, adopt disulfide dependent abnormal ...
Naw May Pearl Cartee +3 more
doaj +2 more sources
Jagged-mediated lateral induction patterns Notch3 signaling within adult neural stem cell populations [PDF]
Nature CommunicationsIn the adult brain, Notch3 signaling promotes neural stem cell (NSC) quiescence and stemness. It remains unknown how Notch3 signaling levels are controlled and relate to these NSC decisions.
Sara Ortica +5 more
doaj +2 more sources
NOTCH3 regulates myofibroblastic CAF differentiation via the P62–ROS signaling axis to promote bladder cancer progression [PDF]
Journal of Experimental & Clinical Cancer ResearchCancer-associated fibroblasts (CAFs) are important contributors to malignant progression in bladder cancer (BLCA), yet the mechanisms by which they promote tumor progression remain incompletely understood.
Ding Hu +13 more
doaj +2 more sources
Use of antisense oligonucleotides to target Notch3 in skeletal cells.
PLoS ONE, 2022 Notch receptors are determinants of cell fate and function, and play an important role in the regulation of bone development and skeletal remodeling. Lateral Meningocele Syndrome (LMS) is a monogenic disorder associated with NOTCH3 pathogenic variants ...
Ernesto Canalis +4 more
doaj +3 more sources
Detection of Vascular Notch3 Deposits in Unfixed Frozen Skin Biopsy Sample in CADASIL
Frontiers in Neurology, 2022 This study aimed to evaluate the utility of immunohistochemical staining of vascular Notch3 deposits in biopsied unfixed frozen skin samples from patients with suspected cerebral autosomal dominant arteriopathy with subcortical infarcts and ...
Akihiko Ueda +8 more
doaj +1 more source