New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools [PDF]
, 2019 BACKGROUND: Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and a high rate of recurrence. Primary and acquired platinum resistance is related to a low response probability to subsequent lines of ...
Carnero Moya, Amancio +10 more
core +1 more source
Carotid Atherosclerotic Markers in CADASIL [PDF]
, 2011 Purpose: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small vessel disease caused by mutations of the NOTCH3 gene. Marked variations in disease severity have raised the hypothesis that
Aout, Mounir +7 more
core +1 more source
Thrombospondin 2 Potentiates Notch3/Jagged1 Signaling [PDF]
Journal of Biological Chemistry, 2009 Extracellular thrombospondins (TSP or THBS) and the Notch family of transmembrane receptors share a role in multiple, overlapping cellular functions and participate in developmental signaling and pathological reactions to tissue injury. We demonstrate that TSP2, but not TSP1, enhances the potency of Notch3 signal transduction. In addition, TSP2 reduces
He, Meng +3 more
openaire +2 more sources
Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications [PDF]
, 2020 Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells in the adult, pericyte activation
Haas, Tara +2 more
core +1 more source
Corrigendum: Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection [PDF]
, 2017 No abstract ...
Grubhoffer, Libor +6 more
core +1 more source
Cellular Physiology and Biochemistry, 2014 Aim: To study the relation of NOTCH3 and its gene polymorphisms with the chemotherapy response and the prognosis of patients with Non-small cell lung cancer (NSCLC).
Chunlei Shi +4 more
doaj +1 more source
Vascular NOTCH3 Deposition Load: Association With <i>NOTCH3</i> Genotype and CADASIL Disease Severity. [PDF]
Neurol GenetCheng YW +6 more
europepmc +2 more sources
Confluent Thalamic Hyperintensities in CADASIL [PDF]
, 2010 Background: CADASIL is responsible for diffuse hyperintensities in the white matter on FLAIR images. These lesions are often associated with focal lesions in the basal ganglia such as lacunar infarctions.
Chabriat, Hugues +6 more
core +1 more source
Notch3 Pathway Alterations in Ovarian Cancer [PDF]
Cancer Research, 2014 Abstract The Notch pathway plays an important role in the growth of high-grade serous ovarian (HGS-OvCa) and other cancers, but its clinical and biologic mechanisms are not well understood. Here, we found that the Notch pathway alterations are prevalent and significantly related to poor clinical outcome in patients with ovarian cancer.
Hu, Wei +26 more
openaire +3 more sources
NOTCH3 Variants in Patients with Suspected CADASIL
Annals of Indian Academy of Neurology, 2023 Abstract Background: Cerebral autosomal dominant arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL) is the most common hereditary form of cerebral small vessel disease. It is clinically, radiologically, and genetically heterogeneous and is caused by NOTCH3 mutations.
Taskapilioglu, Ozlem +8 more
openaire +5 more sources