Results 31 to 40 of about 14,274 (181)

The expression of ASAP3 and NOTCH3 and the clinicopathological characteristics of adult glioma patients

Open Medicine, 2022
ASAP3 is involved in a variety of biological activities, including cancer progression in humans. In adult glioma, we explore the effects of ASAP3 and NOTCH3 and their relationships on prognosis.
Su Li-ping, Ji Min, Liu Li, Sang Wei, Xue Jing, Wang Bo, Pu Hong-Wei, Zhang Wei   +7 more
doaj   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

Notch3 drives development and progression of cholangiocarcinoma [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Clinical outcomes in cholangiocarcinoma (CC) are poor; few patients are candidates for curative resection, and palliative chemotherapy produces only modest effects on survival. With an increasing incidence, new targets are urgently needed.
Guest, Rachel V., Boulter, Luke, Dwyer, Benjamin J., Kendall, Timothy J., Man, Tak-Yung, Minnis-Lyons, Sarah E., Lu, Wei-Yu, Robson, Andrew J., Gonzalez, Sofia Ferreira, Raven, Alexander, Wojtacha, Davina, Morton, Jennifer P., Komuta, Mina, Roskams, Tania, Wigmore, Stephen J., Sansom, Owen J., Forbes, Stuart J.   +16 more
openaire   +4 more sources

notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish

Disease Models & Mechanisms, 2013
SUMMARY Mutations in the human NOTCH3 gene cause CADASIL syndrome (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy).
Andreas Zaucker, Sara Mercurio, Nitzan Sternheim, William S. Talbot, Florence L. Marlow   +4 more
doaj   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Ginsenoside Rh4 Suppresses Notch3 and PI3K/Akt Pathway to Inhibit Growth and Metastasis of Gastric Cancer Cells

Journal of Cancer Biomoleculars and Therapeutics
Background: Rh4 (a compound derived from ginsenoside) has excellent anti-tumor property. It has been documented that an abnormally elevated level of Notch3 expression is linked to poor prognosis of gastric cancer (GC).
Narasimha M Beeraka, Allaka Nagalakshmi, Allaka Satyavathi, Divya M Kote, Padmanabha Reddy Y, Basappa Basappa, Vladimir N Nikolenko, Gurupadayya Bannimath, Kirill V Bulygin, Mahesh P A   +9 more
doaj   +1 more source

Association of NOTCH3 Gene Polymorphisms with Ischemic Stroke and Its Subtypes: A Meta-Analysis

Medicina, 2019
Background and objectives: NOTCH3 gene variations play a significant role in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Loo Keat Wei, Lyn R. Griffiths, Irene Looi, Cheah Wee Kooi   +3 more
doaj   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

The NOTCH3 score: a pre-clinical CADASIL biomarker in a novel human genomic NOTCH3 transgenic mouse model with early progressive vascular NOTCH3 accumulation [PDF]

Acta Neuropathologica Communications, 2015
CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary small vessel disease caused by mutations in the NOTCH3 gene, leading to toxic NOTCH3 protein accumulation in the small- to medium sized arterioles.
Rutten, J.W., Klever, R.R., Hegeman, I.M., Poole, D.S., Dauwerse, H.G., Broos, L.A.M., Breukel, C., Aartsma-Rus, A.M., Verbeek, J.S., Weerd, L. van der, Duinen, S.G. van, Maagdenberg, A.M.J.M. van den, Oberstein, S.A.J.L.   +12 more
openaire   +3 more sources