Results 31 to 40 of about 16,426 (214)

Extensive Leukoencephalopathy in Spastic Paraplegia Type 4: Possible Role of Cerebral Autosomal Arteriopathy With Subcortical Infarcts and Leukoencephelopathy [PDF]

Journal of Movement Disorders, 2022
Despite recent advances in next-generation sequencing, the underlying etiology of adult-onset leukoencephalopathy has been difficult to elucidate. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a ...
Jin Ho Jung, Jung Hwa Seo, Sukyoon Lee, Young Jin Heo, Donghyun Kim, Eun Joo Chung, Seong-il Oh   +6 more
doaj   +1 more source

Notch3 Signaling and Aggregation as Targets for the Treatment of CADASIL and Other NOTCH3-Associated Small-Vessel Diseases [PDF]

The American Journal of Pathology, 2021
Mutations in the NOTCH3 gene can lead to small-vessel disease in humans, including the well-characterized cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a condition caused by NOTCH3 mutations altering the number of cysteine residues in the extracellular domain of Notch3.
Dorothee Schoemaker, Joseph F. Arboleda-Velasquez   +1 more
openaire   +2 more sources

Notch3 Transactivates Glycogen Synthase Kinase-3-Beta and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer Cells

Cells, 2022
As a critical transformational process in the attributes of epithelial cells, epithelial-to-mesenchymal transition (EMT) is involved in tumor invasion, metastasis, and resistance to treatment, which contributes to the ultimate death of some patients with
Weiling Chen, Yongqu Zhang, Ronghui Li, Wenhe Huang, Xiaolong Wei, De Zeng, Yuanke Liang, Yunzhu Zeng, Min Chen, Lixin Zhang, Wenliang Gao, Yuanyuan Zhu, Yaochen Li, Guojun Zhang   +13 more
doaj   +1 more source

The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between Wnt and Notch signaling pathways. [PDF]

PLoS ONE, 2013
Wnt and Notch signaling pathways both play essential roles and interact closely in development and carcinogenesis, but their interaction in non-small-cell lung cancer (NSCLC) is poorly unknown.
Chunyan Li, Siyang Zhang, Yao Lu, Ying Zhang, Enhua Wang, Zeshi Cui   +5 more
doaj   +1 more source

NOTCH3 Variants and Risk of Ischemic Stroke

PLoS ONE, 2013
Mutations within the NOTCH3 gene cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). CADASIL mutations appear to be restricted to the first twenty-four exons, resulting in the gain or loss of a cysteine amino acid.
Ross, Owen A., Soto-Ortolaza, Alexandra I., Heckman, Michael G., Verbeeck, Christophe, Serie, Daniel J., Rayaprolu, Sruti, Rich, Stephen S., Nalls, Michael A., Singleton, Andrew, Guerreiro, Rita, Kinsella, Emma, Wszolek, Zbigniew K., Brott, Thomas G., Brown, Robert D., Worrall, Bradford B., Meschia, James F.   +15 more
openaire   +5 more sources

Notch3 drives development and progression of cholangiocarcinoma [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Clinical outcomes in cholangiocarcinoma (CC) are poor; few patients are candidates for curative resection, and palliative chemotherapy produces only modest effects on survival. With an increasing incidence, new targets are urgently needed.
Guest, Rachel V., Boulter, Luke, Dwyer, Benjamin J., Kendall, Timothy J., Man, Tak-Yung, Minnis-Lyons, Sarah E., Lu, Wei-Yu, Robson, Andrew J., Gonzalez, Sofia Ferreira, Raven, Alexander, Wojtacha, Davina, Morton, Jennifer P., Komuta, Mina, Roskams, Tania, Wigmore, Stephen J., Sansom, Owen J., Forbes, Stuart J.   +16 more
openaire   +5 more sources

NOTCH3-positive CAFs promotes angiogenesis.

, 2016
A and B: Comparison of the microvessel density (MVD) between NOTCH3(-) CAFs and NOTCH3(+)CAFs cases. Immunofluorostaining for α-SMA (green), NOTCH3 (green) and CD34 (red) using human tongue OSCC samples. Ca, cancer nests.
Takumi Akashi (528834), Hideaki Hirai (2636500), Kou Kayamori (2636503), Akane Yukimori (2636509), Akira Yamaguchi (244184), Kei Sakamoto (402255), Yae Ohata (2636497), Kiyoshi Harada (412571), Ken-ichi Katsube (243566), Yoshio Ohyama (2636506), Masao Saitoh (234574), Hiroyuki Harada (823339)   +11 more
core   +1 more source

Notch 3 Protein, not its Gene Polymorphism, is Associated with the Chemotherapy Response and Prognosis of Advanced NSCLC Patients

Cellular Physiology and Biochemistry, 2014
Aim: To study the relation of NOTCH3 and its gene polymorphisms with the chemotherapy response and the prognosis of patients with Non-small cell lung cancer (NSCLC).
Chunlei Shi, Jialin Qian, Meili Ma, Yanwei Zhang, Baohui Han   +4 more
doaj   +1 more source

RANBP1 Regulates NOTCH3-Mediated Autophagy in High Glucose-Induced Vascular Smooth Muscle Cells

Frontiers in Bioscience-Landmark
Background: Vascular smooth muscle cells(VSMCs) phenotypic switching under hyperglycemic conditions accelerates atherosclerotic progression.
Zhong-jiao Xu, Jian Xu, Wen-jing Lei, Xiang Wang, Qi-lin Zou, Lin-chun Lv, Chong Liu, Wu-ming Hu, Yi-jia Xiang, Jia-yi Shen, Tie-min Wei, Chun-lai Zeng   +11 more
doaj   +1 more source

Pathological changes and molecular ⁃ genetic mechanisms of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a inherited cerebral small vessel disease caused by Notch3 gene mutation. The molecular⁃genetic mechanisms of CADASIL have been still unclear.
SUN Yuan⁃jing, FAN Yu⁃hua
doaj   +1 more source