Results 31 to 40 of about 17,508 (213)

Two novel mutations and a previously unreported intronic polymorphism in the NOTCH3 gene [PDF]

, 2012
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary disease of small vessel caused by mutations in the NOTCH3 gene (NCBI Gene ID: 4854) located on chromosome 19p13.1.
Griffiths, L.R., Menon, S., Maksemous, N, Roy, Bishakha, Smith, Robert, Smith, R.A., Griffiths, Lyn, Maksemous, N., Davies, G., Roy, B, Davis, Gail, Smith, RA, Griffiths, LR, Menon, S, Roy, B., Davies, G, Menon, Saras, Maksemous, Neven   +17 more
core   +1 more source

The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between Wnt and Notch signaling pathways. [PDF]

PLoS ONE, 2013
Wnt and Notch signaling pathways both play essential roles and interact closely in development and carcinogenesis, but their interaction in non-small-cell lung cancer (NSCLC) is poorly unknown.
Chunyan Li, Siyang Zhang, Yao Lu, Ying Zhang, Enhua Wang, Zeshi Cui   +5 more
doaj   +1 more source

Pathological changes and molecular ⁃ genetic mechanisms of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a inherited cerebral small vessel disease caused by Notch3 gene mutation. The molecular⁃genetic mechanisms of CADASIL have been still unclear.
SUN Yuan⁃jing, FAN Yu⁃hua
doaj   +1 more source

Comparison of Longitudinal Changes of Cerebral Small Vessel Disease Markers and Cognitive Function Between Subcortical Vascular Mild Cognitive Impairment With and Without NOTCH3 Variant: A 5-Year Follow-Up Study

Frontiers in Neurology, 2021
No study yet has compared the longitudinal course and prognosis between subcortical vascular cognitive impairment patients with and without genetic component.
Cindy W. Yoon, Young-Eun Kim, Hee Jin Kim, Chang-Seok Ki, Hyejoo Lee, Joung-Ho Rha, Duk L. Na, Sang Won Seo   +7 more
doaj   +1 more source

NOTCH3 active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

, 2022
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease and no preventive or curative therapy is available.
Jin, S, Oliveira, DV, Sandin, J, Del, Gaudio F,, Lundkvist, J, Oberstein, SAJL, Fox, R, Rutten, JW, Coupland, KG, Wang, S   +9 more
core   +1 more source

Notch3 Transactivates Glycogen Synthase Kinase-3-Beta and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer Cells

Cells, 2022
As a critical transformational process in the attributes of epithelial cells, epithelial-to-mesenchymal transition (EMT) is involved in tumor invasion, metastasis, and resistance to treatment, which contributes to the ultimate death of some patients with
Weiling Chen, Yongqu Zhang, Ronghui Li, Wenhe Huang, Xiaolong Wei, De Zeng, Yuanke Liang, Yunzhu Zeng, Min Chen, Lixin Zhang, Wenliang Gao, Yuanyuan Zhu, Yaochen Li, Guojun Zhang   +13 more
doaj   +1 more source

NOTCH3-positive CAFs promotes angiogenesis.

, 2016
A and B: Comparison of the microvessel density (MVD) between NOTCH3(-) CAFs and NOTCH3(+)CAFs cases. Immunofluorostaining for α-SMA (green), NOTCH3 (green) and CD34 (red) using human tongue OSCC samples. Ca, cancer nests.
Takumi Akashi (528834), Hideaki Hirai (2636500), Kou Kayamori (2636503), Akane Yukimori (2636509), Akira Yamaguchi (244184), Kei Sakamoto (402255), Yae Ohata (2636497), Kiyoshi Harada (412571), Ken-ichi Katsube (243566), Yoshio Ohyama (2636506), Masao Saitoh (234574), Hiroyuki Harada (823339)   +11 more
core   +1 more source

Patient with CADASIL – a diagnostic challenge

Annales Academiae Medicae Silesiensis, 2023
INTRODUCTION: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetically determined and hereditary cerebral small vessel disease caused by mutations in the NOTCH3 gene.
Julia Węgrzynek, Agnieszka Tomaszewska, Angelika Wawrzkiewicz-Witkowska   +2 more
doaj   +1 more source

NOTCH3 Variants and Risk of Ischemic Stroke

PLoS ONE, 2013
Mutations within the NOTCH3 gene cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). CADASIL mutations appear to be restricted to the first twenty-four exons, resulting in the gain or loss of a cysteine amino acid.
Ross, Owen A., Soto-Ortolaza, Alexandra I., Heckman, Michael G., Verbeeck, Christophe, Serie, Daniel J., Rayaprolu, Sruti, Rich, Stephen S., Nalls, Michael A., Singleton, Andrew, Guerreiro, Rita, Kinsella, Emma, Wszolek, Zbigniew K., Brott, Thomas G., Brown, Robert D., Worrall, Bradford B., Meschia, James F.   +15 more
openaire   +5 more sources

Notch 3 Protein, not its Gene Polymorphism, is Associated with the Chemotherapy Response and Prognosis of Advanced NSCLC Patients

Cellular Physiology and Biochemistry, 2014
Aim: To study the relation of NOTCH3 and its gene polymorphisms with the chemotherapy response and the prognosis of patients with Non-small cell lung cancer (NSCLC).
Chunlei Shi, Jialin Qian, Meili Ma, Yanwei Zhang, Baohui Han   +4 more
doaj   +1 more source