Results 11 to 20 of about 14,274 (181)

The archetypal R90C CADASIL–NOTCH3 mutation retains NOTCH3 function in vivo [PDF]

Human Molecular Genetics, 2007
Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy (CADASIL) is the most prominent known cause of inherited stroke and vascular dementia in human adult. The disease gene, NOTCH3, encodes a transmembrane receptor primarily expressed in arterial smooth muscle cells (SMC).
Monet, M, Domenga, V, Lemaire, B, Souilhol, C, Langa, F, Babinet, C, Gridley, T, Tournier, Lasserve E, Cohen, Tannoudji M, Joutel, A   +9 more
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NOTCH3 limits the epithelial–mesenchymal transition and predicts a favorable clinical outcome in esophageal cancer

Cancer Medicine, 2021
Background Esophageal squamous cell carcinoma (ESCC) is the deadliest of all human squamous cell carcinomas and is characterized by chemotherapy resistance and poor prognosis associated with the epithelial–mesenchymal transition (EMT).
Norihiro Matsuura, Koji Tanaka, Makoto Yamasaki, Kotaro Yamashita, Takuro Saito, Tomoki Makino, Kazuyoshi Yamamoto, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Hidetoshi Eguchi, Hiroshi Nakagawa, Yuichiro Doki   +12 more
doaj   +1 more source

The Role of Notch3 in Cancer [PDF]

The Oncologist, 2018
Abstract The Notch family is a highly conserved gene group that regulates cell-cell interaction, embryogenesis, and tissue commitment. This review article focuses on the third Notch family subtype, Notch3. Regulation via Notch3 signaling was first implicated in vasculogenesis.
Zviadi, Aburjania, Samuel, Jang, Jason, Whitt, Renata, Jaskula-Stzul, Herbert, Chen, J Bart, Rose   +5 more
openaire   +2 more sources

Lysosome-dependent degradation of Notch3 [PDF]

The International Journal of Biochemistry & Cell Biology, 2009
Notch signaling plays an essential role in diverse biological processes during development and in pathogenesis of diseases ranging from cancer to cerebrovascular disorders. Precise regulation of Notch signaling is essential for normal function and requires both timely activation and inactivation of the intracellular domain (ICD) of Notch receptors.
Lijun, Jia, Genggeng, Yu, Yanmei, Zhang, Michael M, Wang   +3 more
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NOTCH3 Variants in Patients with Suspected CADASIL

Annals of Indian Academy of Neurology, 2023
Abstract Background: Cerebral autosomal dominant arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL) is the most common hereditary form of cerebral small vessel disease. It is clinically, radiologically, and genetically heterogeneous and is caused by NOTCH3 mutations.
Taskapilioglu, Ozlem, Kabay, Sibel C., Tepe, Nermin, Ali, Asuman, Sivaci, Ali O., Seferoglu, Meral, Topak, Ali, Gorukmez, Ozlem, Gorukmez, Orhan   +8 more
openaire   +5 more sources

Extensive Leukoencephalopathy in Spastic Paraplegia Type 4: Possible Role of Cerebral Autosomal Arteriopathy With Subcortical Infarcts and Leukoencephelopathy [PDF]

Journal of Movement Disorders, 2022
Despite recent advances in next-generation sequencing, the underlying etiology of adult-onset leukoencephalopathy has been difficult to elucidate. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a ...
Jin Ho Jung, Jung Hwa Seo, Sukyoon Lee, Young Jin Heo, Donghyun Kim, Eun Joo Chung, Seong-il Oh   +6 more
doaj   +1 more source

Notch3 and the Notch3‐upregulated RNA‐binding protein HuD regulate Ikaros alternative splicing [PDF]

The EMBO Journal, 2007
Constitutive activation of the transmembrane receptor, Notch3, and loss of function of the hematopoietic transcription repressor, Ikaros (IK), play direct roles in T-cell differentiation and leukemogenesis that are dependent on pre-T-cell receptor (pre-TCR) signaling.
BELLAVIA, Diana, Marco Mecarozzi, CAMPESE, Antonio Francesco, GRAZIOLI, PAOLA, TALORA, Claudio, FRATI, Luigi, GULINO, Alberto, SCREPANTI, Isabella   +7 more
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Enhancer remodeling activates NOTCH3 signaling to confer chemoresistance in advanced nasopharyngeal carcinoma

Cell Death and Disease, 2023
Acquired resistance to chemotherapy is one of the major causes of mortality in advanced nasopharyngeal carcinoma (NPC). However, effective strategies are limited and the underlying molecular mechanisms remain elusive.
Lizhen Liu, Peng Deng, Sailan Liu, Jing Han Hong, Rong Xiao, Peiyong Guan, Yali Wang, Peili Wang, Jiuping Gao, Jinghong Chen, Yichen Sun, Jianfeng Chen, Hai-Qiang Mai, Jing Tan   +13 more
doaj   +1 more source

Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction

Neoplasia: An International Journal for Oncology Research, 2022
In multiple myeloma (MM), communication via Notch signaling in the tumor niche stimulates tumor progression and bone destruction. We previously showed that osteocytes activate Notch, increase Notch3 expression, and stimulate proliferation in MM cells. We
Hayley M. Sabol, Tânia Amorim, Cody Ashby, David Halladay, Judith Anderson, Meloney Cregor, Megan Sweet, Intawat Nookaew, Noriyoshi Kurihara, G. David Roodman, Teresita Bellido, Jesus Delgado-Calle   +11 more
doaj   +1 more source

Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer

Technology in Cancer Research & Treatment, 2023
Background : Notch signaling played a critical role in promoting breast tumorigenesis and progression. However, the role and prognostic value of Notch3 combined with DLL4 expression in breast carcinoma had not been explored.
Lin Wang, Ge Cao, Wei Li, Xiao-Wen Chen, Shi-Shuang Xiong, Ya-Nan Mu, Jin-Fang Jiang, Lan Yang, De-Rui Zhang, Yu-Wen Cao   +9 more
doaj   +1 more source