Notch3 in Development, Health and Disease [PDF]
Biomolecules, 2020 Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control cell fate in many developmental and adult tissue contexts.
Samira Hosseini Alghaderi, Martin Baron
exaly +7 more sources
Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. [PDF]
PLoS Genetics, 2014 The Notch3 signaling pathway is thought to play a critical role in cancer development, as evidenced by the Notch3 amplification and rearrangement observed in human cancers.
Jin-Gyoung Jung +7 more
doaj +4 more sources
Reduced SUMOylation impairs NOTCH3 signaling and cell survival in the pathogenesis of CADASIL [PDF]
Cell Communication and SignalingCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vessel disease caused by NOTCH3 mutation.
Lijun Long +5 more
doaj +2 more sources
Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing [PDF]
EMBO Journal, 2007 Constitutive activation of the transmembrane receptor, Notch3, and loss of function of the hematopoietic transcription repressor, Ikaros (IK), play direct roles in T-cell differentiation and leukemogenesis that are dependent on pre-T-cell receptor (pre-TCR) signaling.
Diana Bellavia +2 more
exaly +4 more sources
Necessity of Notch3 signaling in myofiber maturation in a pluripotent stem cell transplant model [PDF]
Skeletal MuscleBackground Pluripotent stem cell-derived myogenic progenitors change from an embryonic to a postnatal molecular signature upon engrafting as satellite cells, which coincides with upregulation of Notch3.
Aline M. S. Yamashita +10 more
doaj +2 more sources
The NOTCH3 score: a pre-clinical CADASIL biomarker in a novel human genomic transgenic mouse model with early progressive vascular NOTCH3 accumulation [PDF]
Acta Neuropathologica Communications, 2015 CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary small vessel disease caused by mutations in the NOTCH3 gene, leading to toxic NOTCH3 protein accumulation in the small- to medium sized arterioles.
Rutten, J.W. +12 more
core +5 more sources
Use of antisense oligonucleotides to target Notch3 in skeletal cells.
PLoS ONE, 2022 Notch receptors are determinants of cell fate and function, and play an important role in the regulation of bone development and skeletal remodeling. Lateral Meningocele Syndrome (LMS) is a monogenic disorder associated with NOTCH3 pathogenic variants ...
Ernesto Canalis +4 more
doaj +2 more sources
Detection of Vascular Notch3 Deposits in Unfixed Frozen Skin Biopsy Sample in CADASIL
Frontiers in Neurology, 2022 This study aimed to evaluate the utility of immunohistochemical staining of vascular Notch3 deposits in biopsied unfixed frozen skin samples from patients with suspected cerebral autosomal dominant arteriopathy with subcortical infarcts and ...
Akihiko Ueda +8 more
doaj +1 more source
Biochemical characterization and cellular effects of CADASIL mutants of NOTCH3. [PDF]
PLoS ONE, 2012 Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the best understood cause of dominantly inherited stroke and results from NOTCH3 mutations that lead to NOTCH3 protein accumulation and selective ...
He Meng +6 more
doaj +1 more source
The archetypal R90C CADASIL–NOTCH3 mutation retains NOTCH3 function in vivo [PDF]
Human Molecular Genetics, 2007 Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy (CADASIL) is the most prominent known cause of inherited stroke and vascular dementia in human adult. The disease gene, NOTCH3, encodes a transmembrane receptor primarily expressed in arterial smooth muscle cells (SMC).
Monet, M +9 more
openaire +2 more sources