Results 1 to 10 of about 3,805 (159)

CADASIL

Revista Médica del Uruguay, 2008
Introducción: el síndrome CADASIL (Cerebral Dominant Arteriopathy with Subcortical Infarcts and Leukoencephlopathy) es una microangiopatía no amiloidea, no ateromatosa que se transmite en forma autosómica dominante y cuyas principales manifestaciones clínicas ocurren a nivel cerebral.
Alicia Vaglio, Marnels Ferreira, Ana Luisa Panuncio, María Antonia Castagnola, Matías Pebet, Soledad De la Peña, Roberto Quadrelli   +6 more
openaire   +3 more sources

Psychotherapy and inhibitory control: Insights from fMRI research

Psychiatry and Clinical Neurosciences, Volume 80, Issue 6, Page 502-509, June 2026.
Aim Despite the widespread clinical use of psychotherapy, the neural mechanisms linking treatment to changes in inhibitory control networks supporting self‐regulation remain unclear. This study addresses this gap by meta‐analyzing neuroimaging research on how psychotherapy affects brain regions involved in inhibitory control.
Gioele Gavazzi, Ozge Ozkan, Viola Benedetti, Fabio Giovannelli, Valdo Ricca, Maria Pia Viggiano   +5 more
wiley   +1 more source

Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI

NeuroImage: Clinical, 2023
Brain damage caused by small vessel disease (SVD) differs between males and females. We aimed to examine the pure sex-specific neuroanatomical mechanisms of SVD adjusted for voxel-based expected effects of age and sex on healthy brain volume.
Xiuqin Jia, Chen Ling, Yingying Li, Jinyuan Zhang, Zhixin Li, Xuejia Jia, Danny J.J. Wang, Zihao Zhang, Yun Yuan, Qi Yang   +9 more
doaj   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, Volume 293, Issue 10, Page 2825-2844, May 2026.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

An unusual case of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy with occipital lobe involvement

Annals of Indian Academy of Neurology, 2016
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant angiopathy caused by a mutation in the notch 3 gene on chromosome 19.
Bhavesh Trikamji, Mariam Thomas, Gasser Hathout, Shrikant Mishra   +3 more
doaj   +1 more source

Status Epilepticus as a Novel Late Complication in CARASIL: A Case Report Expanding the Clinical Spectrum

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT CARASIL may present without systemic features, and seizures including status epilepticus can occur as late‐stage complications. Long‐term neurological monitoring is essential even in patients lacking extra‐neurological manifestations.
Mohammad Amin Najafi, Seyyed Ali Alaei, Alireza Anjam Majoumerd, Seyyed AmirHossein Mirghanizadeh Bafghi, Mahdi Vajdi, Mohammad Reza Najafi   +5 more
wiley   +1 more source

Voxel‐Wise Whole‐Brain Analysis in Quantitative Susceptibility Mapping: A Narrative Review

Human Brain Mapping, Volume 47, Issue 3, 15 February 2026.
Voxel‐wise QSM enables the detection of subtle susceptibility changes and the exploration of disease associations without relying on predefined regions, making it a valuable tool for studying aging and neurological disorders. This review summarizes the complete workflow of voxel‐wise QSM, highlighting post‐processing steps, key methodological ...
Ying Tang, Haodong Zhong, Gaiying Li, Yi Wang, Jianqi Li   +4 more
wiley   +1 more source

Is migraine a common manifestation of CADASIL? Arguments Pros

The Journal of Headache and Pain
Background Migraine with aura (MA) is a hallmark feature of CADASIL, a hereditary small-vessel disease caused by NOTCH3 mutations. While MA is prevalent in CADASIL, its underlying mechanisms remain unclear, and the links observed can be questioned or ...
Hugues Chabriat
doaj   +1 more source

Homozygous NOTCH3 p.R587C mutation in Chinese patients with CADASIL: a case report

BMC Neurology, 2020
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small vessel disease caused by mutations in NOTCH3 gene with remarkable phenotypic heterogeneity.
Ruojie He, Huan Li, Yiming Sun, Menglong Chen, Liang Wang, Yuling Zhu, Cheng Zhang   +6 more
doaj   +1 more source

Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis

Neurobiology of Disease, 2015
Could impaired adult hippocampal neurogenesis be a relevant mechanism underlying CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)? Memory symptoms in CADASIL, the most common hereditary form of vascular
Fanny Ehret, Steffen Vogler, Sherin Pojar, David A. Elliott, Frank Bradke, Barbara Steiner, Gerd Kempermann   +6 more
doaj   +1 more source