Results 41 to 50 of about 6,349 (169)

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in Argentina

Arquivos de Neuro-Psiquiatria, 2015
CADASIL is the most common cause of hereditary stroke and vascular dementia. Published information about this disease in South America is scant. We describe clinical and demographic characteristics of 13 patients (10 families) with CADASIL from Argentina.
Maximiliano A Hawkes, Miguel Wilken, Verónica Bruno, Virginia Pujol-Lereis, Guillermo Povedano, María Saccoliti, Analia Taratuto, Sebastián F Ameriso   +7 more
doaj   +1 more source

Depression in CADASIL patients [PDF]

Archives of Biological Sciences, 2014
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary neurological disease accompanied by recurrent ischemic events, characterized by the presence of psychiatric disorders.
Lačković Maja, Damjanović Aleksandar, Ivković Maja, Pantović Maja, Bajčetić Miloš, Rovčanin Branislav, Pavlović Aleksandra, Šternić Nadežda, Jašović-Gašić Miroslava   +8 more
doaj   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment

MedComm, Volume 7, Issue 9, September 2026.
Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Weiwei Lu, Yuan Zhang, Chen Shi, Yu Tao, Shaoxin Li, Yufang Sun, Fuhai Ji, Dongsheng Jiang, Terrance P. Snutch, Jin Tao   +9 more
wiley   +1 more source

Sex differences in frontotemporal atrophy in CADASIL revealed by 7-Tesla MRI

NeuroImage: Clinical, 2023
Brain damage caused by small vessel disease (SVD) differs between males and females. We aimed to examine the pure sex-specific neuroanatomical mechanisms of SVD adjusted for voxel-based expected effects of age and sex on healthy brain volume.
Xiuqin Jia, Chen Ling, Yingying Li, Jinyuan Zhang, Zhixin Li, Xuejia Jia, Danny J.J. Wang, Zihao Zhang, Yun Yuan, Qi Yang   +9 more
doaj   +1 more source

A collaborative framework for uncovering molecular and cellular drivers of VCID: Foundations for future interventions in dementia

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Vascular‐related factors are now considered major contributors to most forms of dementia, including Alzheimer's disease. However, the degree to which vascular deficits contribute to risk, onset, and progression of cognitive impairment and dementia has only recently been appreciated.
M. Luisa Iruela‐Arispe, Jason D. Hinman, Andrew C. Yang, Fabrice Dabertrand, Jin‐Moo Lee, Gareth R. Howell, The VCID Centers without Walls Network   +6 more
wiley   +1 more source

Alzheimer's disease heterogeneity and co‐pathologies: Defining novel targets, biomarkers, modalities, and research methodologies

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract Alzheimer's disease (AD) is a biologically heterogeneous condition with vascular, proteinopathic, metabolic, and immune processes jointly shaping its clinical expression, trajectory of progression, and response to therapeutic intervention.
Malú Gámez Tansey, Sasha Bozeat, Peter Ackerman, Alireza Atri, Christopher J. Barnum, Patrik Brundin, Carlos Abreu de Carvalho, Adam S. Fleisher, Ana Graf, Elizabeth Head, Geoffrey A. Kerchner, Hartmuth C. Kolb, Akihiko Koyama, Mariel Kozberg, Cheryl E. G. Leyns, Jorge J. Llibre‐Guerra, Niklas Mattsson‐Carlgren, David McKissock, Melissa E. Murray, Liana S. Rosenthal, Carrie Rubel, Suzanne E. Schindler, Julie A. Schneider, Adam J. Schwarz, Kirsten M. Scott, Tamara Seredenina, Duygu Tosun, Rebecca L. Wallings, Hong Wang, Donna M. Wilcock, Maria Carrillo, Simin Mahinrad, Christopher J. Weber   +32 more
wiley   +1 more source

Disturbed integrin expression in the vascular media in CADASIL

, 2016
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an inherited angiopathy characterized by degeneration and loss of vascular smooth muscle cells (VSMCs) of still unknown pathomechanism. Many functions
Dorota Dziewulska, Ewelina Nycz
core   +1 more source

An unusual case of cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy with occipital lobe involvement

Annals of Indian Academy of Neurology, 2016
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant angiopathy caused by a mutation in the notch 3 gene on chromosome 19.
Bhavesh Trikamji, Mariam Thomas, Gasser Hathout, Shrikant Mishra   +3 more
doaj   +1 more source

Late Cognitive or Mood Alterations With ‘Status Cribrosum’ and Diffuse White Matter Lesions: A New Cerebral Small Vessel Disease Phenotype Associated With Rare COL4A1 Variants Located Within Exon 23

European Journal of Neurology, Volume 33, Issue 7, July 2026.
We report four unrelated patients carrying rare COL4A1 glycine variants encoded by exon 23 and presenting with late‐onset cognitive and/or psychiatric symptoms. Brain MRI was characterised by a severe cerebral small vessel disease with diffuse white matter hyperintensities and prominent enlargement of basal ganglia perivascular spaces leading to a ...
Hélène Morel, Sophie Dufourd‐Delalande, William Bloch, Mathilde Graber, Sacha Weber, Carla Machado, Thibault Coste, Hugues Chabriat, Elisabeth Tournier‐Lasserve, Stéphanie Guey   +9 more
wiley   +1 more source