Results 41 to 50 of about 8,915 (192)

CADASIL in Arabs: clinical and genetic findings [PDF]

, 2007
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is increasingly recognized as an inherited arterial disease leading to a step-wise decline and eventually to dementia.
Saeed Bohlega, Asmahan Al Shubili, Abdulrahman Edris, Abdulrahman Alreshaid, Thamer AlKhairallah, M Walid AlSous, Samir Farah, Khaled K Abu-Amero, A Joutel, DW Desmond, M Dichgans, H Chabriat, DW Desmond, RN Kalaria, MJ Alberts, N Peters, A Federico, SS Razvi, PD Stenson, U Utku, S Fukao, SC Tang, YC Lee, JF Arboleda-Velasquez, GC Roman, SA Oberstein   +25 more
core   +2 more sources

PSMD‐2: A fully automated marker for longitudinal assessment of cerebrovascular white matter injury [PDF]

Alzheimers Dement
Abstract Background Cerebral small vessel disease (SVD) is highly prevalent in older adults and a key comorbidity in neurodegenerative conditions such as Alzheimer's disease. While conventional MRI markers (e.g. white matter hyperintensities) capture late SVD stages, diffusion MRI metrics are sensitive to early SVD‐related brain changes, making them ...
Dewenter A, Gesierich B, Kopczak A, Oberstein S, Rutten J, Gravesteijn G, Franzmeier N, Markus H, Duering M.   +8 more
europepmc   +4 more sources

Lenticulostriate Arteries and Basal Ganglia Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy, a High-Field MRI Study

Frontiers in Neurology, 2019
Background and Purpose: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) mainly affects the cerebral small arteries.
Chen Ling, Xiaojing Fang, Xiaojing Fang, Qingle Kong, Qingle Kong, Qingle Kong, Yunchuang Sun, Bo Wang, Bo Wang, Bo Wang, Yan Zhuo, Yan Zhuo, Yan Zhuo, Jing An, Wei Zhang, Zhaoxia Wang, Zihao Zhang, Zihao Zhang, Zihao Zhang, Yun Yuan   +19 more
doaj   +1 more source

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL): Three case reports from Serbia [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2008
Introduction Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary microangiopathy leading to recurrent strokes and vascular dementia in young and middleaged patients.
Zidverc-Trajković Jasna, Lačković Vesna, Pavlović Aleksandra, Bajčetić Miloš, Carević Zvonko, Tomić Gordana, Mandić Gorana, Mijajlović Milija, Jovanović Zagorka, Šternić Nadežda   +9 more
doaj   +1 more source

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

EMBO Molecular Medicine, 2022
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease; no preventive or curative therapy is available. CADASIL is caused by mutations in the
Daniel V Oliveira, Kirsten G Coupland, Wenchao Shao, Shaobo Jin, Francesca Del Gaudio, Sailan Wang, Rhys Fox, Julie W Rutten, Johan Sandin, Henrik Zetterberg, Johan Lundkvist, Saskia AJ Lesnik Oberstein, Urban Lendahl, Helena Karlström   +13 more
doaj   +1 more source

Neurological and systemic manifestations of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL): a nationwide study in Korea [PDF]

Alzheimers Dement
Abstract Background This study investigated the epidemiological and clinical features of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) in South Korea, comparing patients to age‐ and sex‐matched controls.
Jung Y.
europepmc   +2 more sources

CADASIL Argentine Registry: Study Design and Preliminary Data [PDF]

Alzheimers Dement
Abstract Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common hereditary small vessel disease, leads to early‐onset stroke and vascular cognitive impairment (VCI). Despite its importance, data from Latin America remain scarce.
Cristalli C, Rosales J, Gonzalez F, Selvaggi V, Alonso J, López J, Aguilar M, Kauffman M, Saks D, Allegri R, Sevlever G, Chaves H, Cristalli D, Calandri I.   +13 more
europepmc   +2 more sources

Psychotherapy and inhibitory control: Insights from fMRI research

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Despite the widespread clinical use of psychotherapy, the neural mechanisms linking treatment to changes in inhibitory control networks supporting self‐regulation remain unclear. This study addresses this gap by meta‐analyzing neuroimaging research on how psychotherapy affects brain regions involved in inhibitory control.
Gioele Gavazzi, Ozge Ozkan, Viola Benedetti, Fabio Giovannelli, Valdo Ricca, Maria Pia Viggiano   +5 more
wiley   +1 more source

Mechanistic advances in factors influencing phenotypic variability in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a review

Frontiers in Neurology
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic cerebral small-vessel disease caused by mutations in NOTCH3 and is the most common hereditary cerebral small-vessel disease in adults. The
Ying Zhao, YaRu Lu, FengYu Wang, YaDan Wang, YaQiong Li, RuiHua Sun, JunKui Shang, Chao Jiang, Jiewen Zhang   +8 more
doaj   +1 more source

Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation. [PDF]

, 2018
BACKGROUND AND PURPOSE:Cerebral microbleeds are linked to cognitive decline, but it remains unclear how they impair neuronal function. Infarction is not typically observed near microbleeds, suggesting more subtle mechanisms, such as inflammation, may ...
Ahn, Sung Ji, Anrather, Josef, Nishimura, Nozomi, Schaffer, Chris B   +3 more
core   +1 more source