Results 1 to 10 of about 11,037 (135)

HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36 [PDF]

mBio
Human cytomegalovirus (HCMV) establishes latency in CD34+ hematopoietic progenitor cells (HPCs), where reactivation is intimately linked to cellular differentiation.
Aaron Dirck, Nicole Diggins, Wilma Perez, Christopher Parkins, Michael Daily, Rebekah L. Turner, Luke Slind, Linh Nguyen, Daniel Malouli, Guanming Wu, Meaghan Hancock, Patrizia Caposio   +11 more
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CADASIL or NOTCH3 mutaion spectrum diseases? Interpretation of NOTCH3 mutations and clinical heterogeneity in CADASIL [PDF]

Frontiers in Neurology
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant disorder characterized by midlife-onset cerebrovascular disease and dementia.
Yuehui Wang, Yiran Liu, Hongbin Mo, Yue Han, Yuanyuan Jing, Fang Deng   +5 more
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Role of Notch gene receptors as prognostic biomarkers in colorectal cancer [PDF]

Scientific Reports
The incidence of colorectal cancer (CRC) is increasing across the world, especially in younger age groups and the Indian subcontinent. Dysregulation in Notch pathway genes and their Single Nucleotide Polymorphism (SNPs) can potentially lead to aberrant ...
Abhay Kumar Sharma, Nimisha Nimisha, Arun Kumar, Apurva Apurva, Abhishek Kumar, Ejaj Ahmad, Asgar Ali, Birendra Prasad, Sundeep Singh Saluja   +8 more
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The aggressive colorectal cancer subtype marker HTR2B has a dual role depending on the tumor microenvironment [PDF]

Cell Communication and Signaling
Colorectal cancer (CRC) is the second-third most frequent cancer type in the Western countries, with significant inter- and intra-patient cellular heterogeneity.
Idan Carmi, Adrián Orosz, Szabolcs Hajdó, Anikó Zeöld, Tamás Hegedűs, Dóra Kelemen-Győri, Julianna Pozsár, Tamás Tölgyes, Zoltán Wiener   +8 more
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NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

Cell Reports Medicine, 2021
Summary: Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive.
Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christopher J. O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra   +22 more
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The Role of Notch3 Signaling in Cancer Stemness and Chemoresistance: Molecular Mechanisms and Targeting Strategies

Frontiers in Molecular Biosciences, 2021
Aberrant Notch signaling profoundly affects cancer progression. Especially the Notch3 receptor was found to be dysregulated in cancer, where its expression is correlated with worse clinicopathological features and poor prognosis. The activation of Notch3
Mengxi Xiu, Mengxi Xiu, Yongbo Wang, Yongbo Wang, Baoli Li, Baoli Li, Xifeng Wang, Fan Xiao, Fan Xiao, Shoulin Chen, Shoulin Chen, Lieliang Zhang, Lieliang Zhang, Bin Zhou, Bin Zhou, Fuzhou Hua, Fuzhou Hua   +16 more
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The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression

Disease Models & Mechanisms, 2021
Infantile myofibromatosis (IMF) is a benign tumor form characterized by the development of nonmetastatic tumors in skin, bone, muscle and sometimes viscera. Autosomal-dominant forms of IMF are caused by mutations in the PDGFRB gene, but a family carrying
Dan Wu, Sailan Wang, Daniel V. Oliveira, Francesca Del Gaudio, Michael Vanlandewijck, Thibaud Lebouvier, Christer Betsholtz, Jian Zhao, ShaoBo Jin, Urban Lendahl, Helena Karlström   +10 more
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Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer

Technology in Cancer Research & Treatment, 2023
Background : Notch signaling played a critical role in promoting breast tumorigenesis and progression. However, the role and prognostic value of Notch3 combined with DLL4 expression in breast carcinoma had not been explored.
Lin Wang, Ge Cao, Wei Li, Xiao-Wen Chen, Shi-Shuang Xiong, Ya-Nan Mu, Jin-Fang Jiang, Lan Yang, De-Rui Zhang, Yu-Wen Cao   +9 more
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NOTCH3 limits the epithelial–mesenchymal transition and predicts a favorable clinical outcome in esophageal cancer

Cancer Medicine, 2021
Background Esophageal squamous cell carcinoma (ESCC) is the deadliest of all human squamous cell carcinomas and is characterized by chemotherapy resistance and poor prognosis associated with the epithelial–mesenchymal transition (EMT).
Norihiro Matsuura, Koji Tanaka, Makoto Yamasaki, Kotaro Yamashita, Takuro Saito, Tomoki Makino, Kazuyoshi Yamamoto, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Hidetoshi Eguchi, Hiroshi Nakagawa, Yuichiro Doki   +12 more
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The association between NOTCH3 expression and the clinical outcome in the urothelial bladder cancer patients

Biomolecules & Biomedicine, 2022
Disrupted NOTCH activity is a driving event in urothelial bladder cancer (UBC). After activation by hypoxia, the NOTCH3 receptor participates in tumor cell proliferation, acquisition of the epithelial-mesenchymal transition phenotype, and angiogenesis ...
Ana Ristic Petrovic, Dragana Stokanović, Slavica Stojnev, Milena Potić Floranović, Miljan Krstić, Ivana Djordjević, Aleksandar Skakić, Ljubinka Janković Veličković   +7 more
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