Results 1 to 10 of about 11,395 (136)
Analysis of Notch1 and Notch3 Signaling Pathway Components in Benign Prostatic Hyperplasia and Prostate Cancer Patients. [PDF]
J Clin Lab AnalThis study evaluates the association between Notch1 and Notch3 genetic variations and serum protein levels in patients with benign prostatic hyperplasia and prostate cancer. While genetic variations showed no significant link to disease risk, serum protein levels were significantly lower in prostate cancer and metastatic groups compared to healthy ...
Yagci E +4 more
europepmc +2 more sources
Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor-Ligand Interactions. [PDF]
Adv Sci (Weinh)This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Kim G +8 more
europepmc +2 more sources
HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36 [PDF]
mBioHuman cytomegalovirus (HCMV) establishes latency in CD34+ hematopoietic progenitor cells (HPCs), where reactivation is intimately linked to cellular differentiation.
Aaron Dirck +11 more
doaj +2 more sources
Cell Reports Medicine, 2021 Summary: Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive.
Kenneth G. Geles +22 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Aberrant Notch signaling profoundly affects cancer progression. Especially the Notch3 receptor was found to be dysregulated in cancer, where its expression is correlated with worse clinicopathological features and poor prognosis. The activation of Notch3
Mengxi Xiu +16 more
doaj +1 more source
Disease Models & Mechanisms, 2021 Infantile myofibromatosis (IMF) is a benign tumor form characterized by the development of nonmetastatic tumors in skin, bone, muscle and sometimes viscera. Autosomal-dominant forms of IMF are caused by mutations in the PDGFRB gene, but a family carrying
Dan Wu +10 more
doaj +1 more source
Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer
Technology in Cancer Research & Treatment, 2023 Background : Notch signaling played a critical role in promoting breast tumorigenesis and progression. However, the role and prognostic value of Notch3 combined with DLL4 expression in breast carcinoma had not been explored.
Lin Wang +9 more
doaj +1 more source
Cancer Medicine, 2021 Background Esophageal squamous cell carcinoma (ESCC) is the deadliest of all human squamous cell carcinomas and is characterized by chemotherapy resistance and poor prognosis associated with the epithelial–mesenchymal transition (EMT).
Norihiro Matsuura +12 more
doaj +1 more source
Biomolecules & Biomedicine, 2022 Disrupted NOTCH activity is a driving event in urothelial bladder cancer (UBC). After activation by hypoxia, the NOTCH3 receptor participates in tumor cell proliferation, acquisition of the epithelial-mesenchymal transition phenotype, and angiogenesis ...
Ana Ristic Petrovic +7 more
doaj +1 more source
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
EMBO Molecular Medicine, 2022 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease; no preventive or curative therapy is available. CADASIL is caused by mutations in the
Daniel V Oliveira +13 more
doaj +1 more source