Results 1 to 10 of about 16,615 (204)

NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells [PDF]

Cell Reports Medicine, 2021
Summary: Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive.
Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christopher J. O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra   +22 more
doaj   +3 more sources

HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36 [PDF]

mBio
Human cytomegalovirus (HCMV) establishes latency in CD34+ hematopoietic progenitor cells (HPCs), where reactivation is intimately linked to cellular differentiation.
Aaron Dirck, Nicole Diggins, Wilma Perez, Christopher Parkins, Michael Daily, Rebekah L. Turner, Luke Slind, Linh Nguyen, Daniel Malouli, Guanming Wu, Meaghan Hancock, Patrizia Caposio   +11 more
doaj   +2 more sources

CADASIL or NOTCH3 mutaion spectrum diseases? Interpretation of NOTCH3 mutations and clinical heterogeneity in CADASIL [PDF]

Frontiers in Neurology
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant disorder characterized by midlife-onset cerebrovascular disease and dementia.
Yuehui Wang, Yiran Liu, Hongbin Mo, Yue Han, Yuanyuan Jing, Fang Deng   +5 more
doaj   +2 more sources

Is the oxidant/antioxidant status altered in CADASIL patients? [PDF]

PLoS ONE, 2013
The altered aggregation of proteins in non-native conformation is associated with endoplasmic reticulum derangements, mitochondrial dysfunction and excessive production of reactive oxygen species. Cerebral autosomal dominant arteriopathy with subcortical
Jonica Campolo, Renata De Maria, Caterina Mariotti, Chiara Tomasello, Marina Parolini, Marina Frontali, Domenico Inzitari, Raffaella Valenti, Antonio Federico, Franco Taroni, Oberdan Parodi   +10 more
doaj   +9 more sources

Role of Notch gene receptors as prognostic biomarkers in colorectal cancer [PDF]

Scientific Reports
The incidence of colorectal cancer (CRC) is increasing across the world, especially in younger age groups and the Indian subcontinent. Dysregulation in Notch pathway genes and their Single Nucleotide Polymorphism (SNPs) can potentially lead to aberrant ...
Abhay Kumar Sharma, Nimisha Nimisha, Arun Kumar, Apurva Apurva, Abhishek Kumar, Ejaj Ahmad, Asgar Ali, Birendra Prasad, Sundeep Singh Saluja   +8 more
doaj   +2 more sources

Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation [PDF]

Molecular Cancer, 2011
Background Pancreas cancer is one of most aggressive human cancers with the survival rate for patients with metastatic pancreas cancer at 5-6 months. The poor survival demonstrates a clear need for better target identification, drug development and new ...
Vo Kevin, Amarasinghe Barushi, Washington Kay, Gonzalez Adriana, Berlin Jordan, Dang Thao P   +5 more
doaj   +2 more sources

The aggressive colorectal cancer subtype marker HTR2B has a dual role depending on the tumor microenvironment [PDF]

Cell Communication and Signaling
Colorectal cancer (CRC) is the second-third most frequent cancer type in the Western countries, with significant inter- and intra-patient cellular heterogeneity.
Idan Carmi, Adrián Orosz, Szabolcs Hajdó, Anikó Zeöld, Tamás Hegedűs, Dóra Kelemen-Győri, Julianna Pozsár, Tamás Tölgyes, Zoltán Wiener   +8 more
doaj   +2 more sources

The Role of Notch3 Signaling in Cancer Stemness and Chemoresistance: Molecular Mechanisms and Targeting Strategies

Frontiers in Molecular Biosciences, 2021
Aberrant Notch signaling profoundly affects cancer progression. Especially the Notch3 receptor was found to be dysregulated in cancer, where its expression is correlated with worse clinicopathological features and poor prognosis. The activation of Notch3
Mengxi Xiu, Mengxi Xiu, Yongbo Wang, Yongbo Wang, Baoli Li, Baoli Li, Xifeng Wang, Fan Xiao, Fan Xiao, Shoulin Chen, Shoulin Chen, Lieliang Zhang, Lieliang Zhang, Bin Zhou, Bin Zhou, Fuzhou Hua, Fuzhou Hua   +16 more
doaj   +1 more source

DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation [PDF]

, 2015
The acquisition of endocrine therapy resistance in estrogen receptor a (ERa) breast cancer patients represents a major clinical problem. Notch signalling has been extensively linked to breast cancer especially in patients who fail to respond to endocrine
Aifantis, Apatira, Apweiler, Brennan, Carroll, Chazotte, Chen, Coombes, Darbre, Eikesdal, Forgac, Goloubeva, Gul, Hill, Ho, Joffe, Johnston, Jones, Jones, Jones, Kane, Kang, Kocak, Lake, Le Borgne, Lendahl, Liu, Lupien, Mader, Mao, Martinez, McPherson, Medici, Meyer, Miele, Miele, Miele, Miyamoto, Nguyen, Nicolson, Roegiers, Sarkar, Schiff, Schilling, Schupbach, Sutherland, Taylor, Urbe, Vaccari, Venkanteshan, Wang, Webster, Wieczorek, Wong, Zahler   +54 more
core   +11 more sources

The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression

Disease Models & Mechanisms, 2021
Infantile myofibromatosis (IMF) is a benign tumor form characterized by the development of nonmetastatic tumors in skin, bone, muscle and sometimes viscera. Autosomal-dominant forms of IMF are caused by mutations in the PDGFRB gene, but a family carrying
Dan Wu, Sailan Wang, Daniel V. Oliveira, Francesca Del Gaudio, Michael Vanlandewijck, Thibaud Lebouvier, Christer Betsholtz, Jian Zhao, ShaoBo Jin, Urban Lendahl, Helena Karlström   +10 more
doaj   +1 more source