Low Density Lipoprotein Receptor-related Protein-1 (LRP1) Regulates Thrombospondin-2 (TSP2) Enhancement of Notch3 Signaling [PDF]
Journal of Biological Chemistry, 2010 Intracellular trafficking of Notch and Notch ligands modulates signaling, suggesting that choreography of ligand and receptor translocation is essential for optimal Notch activity. Indeed, a major model for Notch signaling posits that Notch trans-endocytosis into the ligand-expressing (signal sending) cell is a key driving force for Notch signal ...
He, Meng +5 more
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Notch receptor expression in neurogenic regions of the adult zebrafish brain. [PDF]
PLoS ONE, 2013 The adult zebrash brain has a remarkable constitutive neurogenic capacity. The regulation and maintenance of its adult neurogenic niches are poorly understood.
Vanessa de Oliveira-Carlos +5 more
doaj +1 more source
Notch3 targeting. A novel weapon against ovarian cancer stem cells [PDF]
, 2019 Notch signaling is frequently activated in ovarian cancer (OC) and contributes to the proliferation and survival of cultured OC cells as well as to tumor formation and angiogenesis in xenograft models.
Bellavia, Diana +5 more
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Dominant-Negative Notch3 Receptor Inhibits Mitogen-Activated Protein Kinase Pathway and the Growth of Human Lung Cancers [PDF]
Cancer Research, 2005 Abstract Notch3 is a member of an evolutionarily conserved family of cell surface receptors important in cell-fate determination in both vertebrates and invertebrates. Significant data support the role of Notch pathway in cancer development, although the conflicting role of Notch signaling pathways in tumorigenesis suggests that its ...
Nobuhiro, Haruki +7 more
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Frontiers in Cell and Developmental Biology, 2020 Our previous study found that Notch3 knockout mice exhibit defects in mammary gland development. To elucidate the underlying mechanism, tissue samples were subjected to RNA-seq, GO, and KEGG enrichment analyses and qRT-PCR validation.
Wei Xiong +6 more
doaj +1 more source
Cells, 2021 In Notch signaling, the Jagged1-Notch3 ligand-receptor pairing is implicated for regulating the phenotype maturity of vascular smooth muscle cells. However, less is known about the role of Jagged1 presentation strategy in this regulation.
Kathleen Zohorsky +2 more
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The Skeleton of Lateral Meningocele Syndrome
Frontiers in Genetics, 2021 Notch (Notch1 through 4) are transmembrane receptors that determine cell differentiation and function, and are activated following interactions with ligands of the Jagged and Delta-like families.
Ernesto Canalis
doaj +1 more source
Clinical and epidemiological profiles from a case series of 26 Brazilian CADASIL patients
Arquivos de Neuro-Psiquiatria, 2023 Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic cause of ischemic stroke and the most common form of non-atherosclerotic stroke.
Renata Nogueira +4 more
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The Potential Roles of Long Noncoding RNAs (lncRNA) in Glioblastoma Development [PDF]
, 2016 Long noncoding RNA (lncRNA) may contribute to the initiation and progression of tumor. In this study, we first systematically compared lncRNA and mRNA expression between glioblastoma and paired normal brain tissues using microarray data.
Eischen, Christine M. +6 more
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Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide. [PDF]
, 2015 BackgroundTemozolomide (TMZ) is an oral DNA-alkylating agent used for treating patients with glioblastoma. However, therapeutic benefits of TMZ can be compromised by the expression of O6-methylguanine methyltransferase (MGMT) in tumor tissue.
Bui, Yvonne +14 more
core +2 more sources