Results 31 to 40 of about 1,245,456 (166)

Bruceine H Mediates EGFR-TKI Drug Persistence in NSCLC by Notch3-Dependent β-Catenin Activating FOXO3a Signaling

Frontiers in Oncology, 2022
Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR) protein serve as a critical pillar in the treatment of non-small cell lung cancer (NSCLC), but resistance is universal.
Jiahui Wu, Xiao He, Ziwei Xiong, Lingyu Shi, Daofeng Chen, Yulin Feng, Quan Wen   +6 more
doaj   +1 more source

The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation

Cells, 2021
Basal cells (BCs) are stem/progenitor cells of the mucociliary airway epithelium, and their differentiation is orchestrated by the NOTCH signaling pathway.
Manish Bodas, Bharathiraja Subramaniyan, Andrew R. Moore, Jordan P. Metcalf, Sarah R. Ocañas, Willard M. Freeman, Constantin Georgescu, Jonathan D. Wren, Matthew S. Walters   +8 more
doaj   +1 more source

The Notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms

, 2018
During evolution, gene duplication of the Notch receptor suggests a progressive functional diversification. The Notch3 receptor displays a number of structural differences with respect to Notch1 and Notch2, most of which have been reported in the ...
Isabella Screpanti, Saula Checquolo, Diana Bellavia, Rocco Palermo   +3 more
core   +1 more source

Novel mechanism of resistance to targeted therapies in lung cancer

Molecular & Cellular Oncology, 2019
We have identified a non-canonical role of0 Notch3 in response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy, whereby Notch3 associates with β-catenin, resulting in increased catenin beta-1 (CTNNB1, best known as β ...
Walter Wang, David P. Carbone, Rajeswara Rao Arasada   +2 more
doaj   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Sepsis downregulates aortic Notch signaling to produce vascular hyporeactivity in mice

Scientific Reports, 2022
Inhibition of Notch signaling in macrophages is known to reduce inflammation, however, its role in regulating vascular hyporeactivity in sepsis is unknown. Thus we aimed to evaluate the effect of sepsis on vascular Notch signaling.
Vandana Singh, Raut Akash, Gaurav Chaudhary, Rajneesh Singh, Soumen Choudhury, Amit Shukla, Shyama N. Prabhu, Neeraj Gangwar, Satish K. Garg   +8 more
doaj   +1 more source

Pathological changes and molecular ⁃ genetic mechanisms of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a inherited cerebral small vessel disease caused by Notch3 gene mutation. The molecular⁃genetic mechanisms of CADASIL have been still unclear.
SUN Yuan⁃jing, FAN Yu⁃hua
doaj   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Notch3 marks clonogenic mammary luminal progenitor cells in vivo

, 2013
International audienceThe identity of mammary stem and progenitor cells remains poorly understood, mainly as a result of the lack of robust markers. The Notch signaling pathway has been implicated in mammary gland development as well as in tumorigenesis ...
Fre, Silvia, Daniel Lafkas, Silvia Fre, Lafkas, Daniel, Mourao, Larissa, Kiaris, Hippokratis, Mathilde Huyghe, Huyghe, Mathilde, Veronica Rodilla, Larissa Mourao, Hippokratis Kiaris, Rodilla, Veronica   +11 more
core   +3 more sources

CD248/Endosialin regulates synovial fibroblast state to control coupling of inflammation and bone damage in murine models of immune‐mediated inflammatory arthritis and ageing

Arthritis &Rheumatology, Accepted Article.
Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/Endosialin is expressed by fibroblasts in the synovium, is highly upregulated during inflammation and has been proposed as a potential therapeutic target.
Samuel Kemble, Corinna Wehmeyer, James M. Brown, Charlotte G. Smith, Holly R. Adams, Eva Crombie, Ellie Northall, Maryam Imran, Paulynn Chin, Harris R. Perlman, Christopher D. Buckley, Adam P. Croft, Amy J. Naylor   +12 more
wiley   +1 more source