Results 21 to 30 of about 16,800 (210)
The aggressive colorectal cancer subtype marker HTR2B has a dual role depending on the tumor microenvironment [PDF]
Cell Communication and SignalingColorectal cancer (CRC) is the second-third most frequent cancer type in the Western countries, with significant inter- and intra-patient cellular heterogeneity.
Idan Carmi +8 more
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Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins [PDF]
Molecular and Cellular Biology, 2014 In mammals, there are four NOTCH receptors and five Delta-Jagged-type ligands regulating many aspects of embryonic development and adult tissue homeostasis. NOTCH proteins are type I transmembrane receptors that interact with ligands on adjacent cells and are activated by regulated intramembrane proteolysis (RIP).
Groot, Arjan J. +7 more
openaire +3 more sources
Frontiers in Molecular Biosciences, 2021 Aberrant Notch signaling profoundly affects cancer progression. Especially the Notch3 receptor was found to be dysregulated in cancer, where its expression is correlated with worse clinicopathological features and poor prognosis. The activation of Notch3
Mengxi Xiu +16 more
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DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation [PDF]
, 2015 The acquisition of endocrine therapy resistance in estrogen receptor a (ERa) breast cancer patients represents a major clinical problem. Notch signalling has been extensively linked to breast cancer especially in patients who fail to respond to endocrine
Aifantis +54 more
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Disease Models & Mechanisms, 2021 Infantile myofibromatosis (IMF) is a benign tumor form characterized by the development of nonmetastatic tumors in skin, bone, muscle and sometimes viscera. Autosomal-dominant forms of IMF are caused by mutations in the PDGFRB gene, but a family carrying
Dan Wu +10 more
doaj +1 more source
The emerging role of NOTCH3 receptor signalling in human lung diseases
Expert Reviews in Molecular Medicine, 2022 Abstract The mammalian respiratory system or lung is a tree-like branching structure, and the main site of gas exchange with the external environment. Structurally, the lung is broadly classified into the proximal (or conducting) airways and the distal alveolar region, where the gas exchange occurs.
Manish Bodas +4 more
openaire +2 more sources
The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients [PDF]
Journal of Clinical Investigation, 2000 Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset arteriopathy), which leads to stroke and dementia in humans. CADASIL arteriopathy is characterized by major alterations of vascular smooth muscle cells and the presence of specific granular osmiophilic deposits.
Joutel, A +9 more
openaire +3 more sources
Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer
Technology in Cancer Research & Treatment, 2023 Background : Notch signaling played a critical role in promoting breast tumorigenesis and progression. However, the role and prognostic value of Notch3 combined with DLL4 expression in breast carcinoma had not been explored.
Lin Wang +9 more
doaj +1 more source
Cancer Medicine, 2021 Background Esophageal squamous cell carcinoma (ESCC) is the deadliest of all human squamous cell carcinomas and is characterized by chemotherapy resistance and poor prognosis associated with the epithelial–mesenchymal transition (EMT).
Norihiro Matsuura +12 more
doaj +1 more source
Biomolecules & Biomedicine, 2022 Disrupted NOTCH activity is a driving event in urothelial bladder cancer (UBC). After activation by hypoxia, the NOTCH3 receptor participates in tumor cell proliferation, acquisition of the epithelial-mesenchymal transition phenotype, and angiogenesis ...
Ana Ristic Petrovic +7 more
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