Results 21 to 30 of about 1,245,456 (166)

Genetic study of the NOTCH3 gene in CADASIL patients

Egyptian Journal of Medical Human Genetics, 2018
Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic, hereditary, neurological syndrome characterized by small vessel disease (SVD), stroke, vascular cognitive impairment and ...
Seyedeh Parisa Chavoshi Tarzjani, Seyed Abolhassan Shahzadeh Fazeli, Mohammad Hossein Sanati, Zahra Mirzayee   +3 more
doaj   +1 more source

Notch receptor expression in neurogenic regions of the adult zebrafish brain. [PDF]

PLoS ONE, 2013
The adult zebrash brain has a remarkable constitutive neurogenic capacity. The regulation and maintenance of its adult neurogenic niches are poorly understood.
Vanessa de Oliveira-Carlos, Julia Ganz, Stefan Hans, Jan Kaslin, Michael Brand, Michael Brand   +5 more
doaj   +1 more source

Notch3 Knockout Suppresses Mouse Mammary Gland Development and Inhibits the Proliferation of 4T1 Murine Mammary Carcinoma Cells via CCL2/CCR4 Axis

Frontiers in Cell and Developmental Biology, 2020
Our previous study found that Notch3 knockout mice exhibit defects in mammary gland development. To elucidate the underlying mechanism, tissue samples were subjected to RNA-seq, GO, and KEGG enrichment analyses and qRT-PCR validation.
Wei Xiong, Junyu Tan, Yuxian Guo, Shuzhao Chen, Liping Fan, Yaochen Li, Yaochen Li   +6 more
doaj   +1 more source

Immobilization of Jagged1 Enhances Vascular Smooth Muscle Cells Maturation by Activating the Notch Pathway

Cells, 2021
In Notch signaling, the Jagged1-Notch3 ligand-receptor pairing is implicated for regulating the phenotype maturity of vascular smooth muscle cells. However, less is known about the role of Jagged1 presentation strategy in this regulation.
Kathleen Zohorsky, Shigang Lin, Kibret Mequanint   +2 more
doaj   +1 more source

Clinical and epidemiological profiles from a case series of 26 Brazilian CADASIL patients

Arquivos de Neuro-Psiquiatria, 2023
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic cause of ischemic stroke and the most common form of non-atherosclerotic stroke.
Renata Nogueira, Christian Marques Couto, Pérola de Oliveira, Bernardo José Alves Ferreira Martins, Vinícius Viana Abreu Montanaro   +4 more
doaj   +1 more source

The Skeleton of Lateral Meningocele Syndrome

Frontiers in Genetics, 2021
Notch (Notch1 through 4) are transmembrane receptors that determine cell differentiation and function, and are activated following interactions with ligands of the Jagged and Delta-like families.
Ernesto Canalis
doaj   +1 more source

CADASIL-causing mutations do not alter Notch3 receptor processing and activation

CADASIL is associated with mutations in the Notch3 gene but the causal mechanisms of the disorder remain unclear. We studied effects of widely established mutations on Notch3 receptor processing and ligand-mediated activation in stable lines of HEK293 ...
Tabira T, Low W-C, Kalaria RN, Santa Y, Takahashi K   +4 more
core   +5 more sources

Notch signaling pathway in human vascular smooth muscle cell differentiation [PDF]

, 2006
Notch receptor-ligand interactions are a highly conserved mechanism, originally described in developmental studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to ...
Scheller, Agnieszka
core   +2 more sources

Prevalence and Atypical Clinical Characteristics of NOTCH3 Mutations Among Patients Admitted for Acute Lacunar Infarctions

Frontiers in Aging Neuroscience, 2020
Objectives: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary small vessel disease, with reported frequencies of 2-5/100,000 individuals. Recently, it has been reported that
Takashi Okada, Kazuo Washida, Kenichi Irie, Satoshi Saito, Satoshi Saito, Michio Noguchi, Tsutomu Tomita, Masatoshi Koga, Kazunori Toyoda, Shuhei Okazaki, Takashi Koizumi, Ikuko Mizuta, Toshiki Mizuno, Masafumi Ihara   +13 more
doaj   +1 more source

NOTCH3-positive CAFs promotes angiogenesis.

, 2016
A and B: Comparison of the microvessel density (MVD) between NOTCH3(-) CAFs and NOTCH3(+)CAFs cases. Immunofluorostaining for α-SMA (green), NOTCH3 (green) and CD34 (red) using human tongue OSCC samples. Ca, cancer nests.
Takumi Akashi (528834), Hideaki Hirai (2636500), Kou Kayamori (2636503), Akane Yukimori (2636509), Akira Yamaguchi (244184), Kei Sakamoto (402255), Yae Ohata (2636497), Kiyoshi Harada (412571), Ken-ichi Katsube (243566), Yoshio Ohyama (2636506), Masao Saitoh (234574), Hiroyuki Harada (823339)   +11 more
core   +1 more source