Results 21 to 30 of about 11,078 (168)
Genetic study of the NOTCH3 gene in CADASIL patients
Egyptian Journal of Medical Human Genetics, 2018 Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic, hereditary, neurological syndrome characterized by small vessel disease (SVD), stroke, vascular cognitive impairment and ...
Seyedeh Parisa Chavoshi Tarzjani +3 more
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Notch receptor expression in neurogenic regions of the adult zebrafish brain. [PDF]
PLoS ONE, 2013 The adult zebrash brain has a remarkable constitutive neurogenic capacity. The regulation and maintenance of its adult neurogenic niches are poorly understood.
Vanessa de Oliveira-Carlos +5 more
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Frontiers in Cell and Developmental Biology, 2020 Our previous study found that Notch3 knockout mice exhibit defects in mammary gland development. To elucidate the underlying mechanism, tissue samples were subjected to RNA-seq, GO, and KEGG enrichment analyses and qRT-PCR validation.
Wei Xiong +6 more
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Cells, 2021 In Notch signaling, the Jagged1-Notch3 ligand-receptor pairing is implicated for regulating the phenotype maturity of vascular smooth muscle cells. However, less is known about the role of Jagged1 presentation strategy in this regulation.
Kathleen Zohorsky +2 more
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Analysis of the expression of the Notch3 receptor protein in adult lung cancer
Oncology Letters, 2012 Abnormalities in the Notch signaling system are considered to play a role in the tumorigenesis of bronchiogenic carcinoma. The present study aimed to investigate the expression of Notch3 in adult lung cancer patients and its role in the pathogenesis of primary bronchiogenic carcinoma. The expression of the Notch3 protein in lung squamous cell carcinoma,
ZHOU, MIN +3 more
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Clinical and epidemiological profiles from a case series of 26 Brazilian CADASIL patients
Arquivos de Neuro-Psiquiatria, 2023 Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic cause of ischemic stroke and the most common form of non-atherosclerotic stroke.
Renata Nogueira +4 more
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The Skeleton of Lateral Meningocele Syndrome
Frontiers in Genetics, 2021 Notch (Notch1 through 4) are transmembrane receptors that determine cell differentiation and function, and are activated following interactions with ligands of the Jagged and Delta-like families.
Ernesto Canalis
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Dominant-Negative Notch3 Receptor Inhibits Mitogen-Activated Protein Kinase Pathway and the Growth of Human Lung Cancers [PDF]
Cancer Research, 2005 Abstract Notch3 is a member of an evolutionarily conserved family of cell surface receptors important in cell-fate determination in both vertebrates and invertebrates. Significant data support the role of Notch pathway in cancer development, although the conflicting role of Notch signaling pathways in tumorigenesis suggests that its ...
Nobuhiro, Haruki +7 more
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Nuclear orphan receptor NR2F6 confers cisplatin resistance in epithelial ovarian cancer cells by activating the Notch3 signaling pathway [PDF]
International Journal of Cancer, 2019 The primary challenge facing treatment of epithelial ovarian cancer (EOC) is the high frequency of chemoresistance, which severely impairs the quality of life and survival of patients with EOC. Our study aims to investigate the mechanisms by which upregulation of NR2F6 induces chemoresistance in EOC. The biological roles of NR2F6 in EOC chemoresistance
Han Li +13 more
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Frontiers in Aging Neuroscience, 2020 Objectives: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary small vessel disease, with reported frequencies of 2-5/100,000 individuals. Recently, it has been reported that
Takashi Okada +13 more
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