Results 41 to 50 of about 16,800 (210)
Frontiers in Cell and Developmental Biology, 2020 Our previous study found that Notch3 knockout mice exhibit defects in mammary gland development. To elucidate the underlying mechanism, tissue samples were subjected to RNA-seq, GO, and KEGG enrichment analyses and qRT-PCR validation.
Wei Xiong +6 more
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Notch receptor expression in neurogenic regions of the adult zebrafish brain. [PDF]
PLoS ONE, 2013 The adult zebrash brain has a remarkable constitutive neurogenic capacity. The regulation and maintenance of its adult neurogenic niches are poorly understood.
Vanessa de Oliveira-Carlos +5 more
doaj +1 more source
CADASIL: A monogenic condition causing stroke and subcortical vascular dementia [PDF]
, 2002 Mutations in Notch3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an inherited small vessel disease leading to subcortical strokes and vascular dementia. The phenotypic presentation
Dichgans, Martin
core +1 more source
Analysis of the expression of the Notch3 receptor protein in adult lung cancer
Oncology Letters, 2012 Abnormalities in the Notch signaling system are considered to play a role in the tumorigenesis of bronchiogenic carcinoma. The present study aimed to investigate the expression of Notch3 in adult lung cancer patients and its role in the pathogenesis of primary bronchiogenic carcinoma. The expression of the Notch3 protein in lung squamous cell carcinoma,
ZHOU, MIN +3 more
openaire +3 more sources
Cells, 2021 In Notch signaling, the Jagged1-Notch3 ligand-receptor pairing is implicated for regulating the phenotype maturity of vascular smooth muscle cells. However, less is known about the role of Jagged1 presentation strategy in this regulation.
Kathleen Zohorsky +2 more
doaj +1 more source
Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications [PDF]
, 2020 Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells in the adult, pericyte activation
Haas, Tara +2 more
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Clinical and epidemiological profiles from a case series of 26 Brazilian CADASIL patients
Arquivos de Neuro-Psiquiatria, 2023 Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic cause of ischemic stroke and the most common form of non-atherosclerotic stroke.
Renata Nogueira +4 more
doaj +1 more source
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation [PDF]
, 2018 Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Alve, S +17 more
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The Skeleton of Lateral Meningocele Syndrome
Frontiers in Genetics, 2021 Notch (Notch1 through 4) are transmembrane receptors that determine cell differentiation and function, and are activated following interactions with ligands of the Jagged and Delta-like families.
Ernesto Canalis
doaj +1 more source
The Potential Roles of Long Noncoding RNAs (lncRNA) in Glioblastoma Development [PDF]
, 2016 Long noncoding RNA (lncRNA) may contribute to the initiation and progression of tumor. In this study, we first systematically compared lncRNA and mRNA expression between glioblastoma and paired normal brain tissues using microarray data.
Eischen, Christine M. +6 more
core +2 more sources