Results 51 to 60 of about 16,615 (204)
Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]
, 2016 The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita +5 more
core +1 more source
Oncology Letters, 2013 Human clinically non-functioning pituitary adenomas (NFPAs) primarily cause headaches, visual impairment and hypopituitarism due to the effect of the mass of the tumor. Surgery is the first-line treatment for these tumors. To date, no efficacious medical therapy exists for non-functioning adenomas.
LU, RUNCHUN +5 more
openaire +3 more sources
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2 and cell proliferation via Gαq-mediated mechanism [PDF]
, 2014 Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Bai, B +5 more
core +2 more sources
Novel mechanism of resistance to targeted therapies in lung cancer
Molecular & Cellular Oncology, 2019 We have identified a non-canonical role of0 Notch3 in response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy, whereby Notch3 associates with β-catenin, resulting in increased catenin beta-1 (CTNNB1, best known as β ...
Walter Wang +2 more
doaj +1 more source
Sepsis downregulates aortic Notch signaling to produce vascular hyporeactivity in mice
Scientific Reports, 2022 Inhibition of Notch signaling in macrophages is known to reduce inflammation, however, its role in regulating vascular hyporeactivity in sepsis is unknown. Thus we aimed to evaluate the effect of sepsis on vascular Notch signaling.
Vandana Singh +8 more
doaj +1 more source
Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a inherited cerebral small vessel disease caused by Notch3 gene mutation. The molecular⁃genetic mechanisms of CADASIL have been still unclear.
SUN Yuan⁃jing, FAN Yu⁃hua
doaj +1 more source
Current views on the role of Notch signaling and the pathogenesis of human leukemia [PDF]
, 2011 The Notch signaling pathway is highly conserved from Drosophila to humans and plays an important role in the regulation of cellular proliferation, differentiation and apoptosis.
Joanna Pancewicz, Christophe Nicot
core +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone [PDF]
, 2017 In the adult mammalian brain, neural stem cells (NSCs) generate new neurons throughout the mammal's lifetime. The balance between quiescence and active cell division among NSCs is crucial in producing appropriate numbers of neurons while maintaining the ...
Furutachi, S +6 more
core +1 more source