Results 51 to 60 of about 1,245,456 (166)

Molecular Characterization of Notch1 Positive Progenitor Cells in the Developing Retina. [PDF]

PLoS ONE, 2015
The oscillatory expression of Notch signaling in neural progenitors suggests that both repressors and activators of neural fate specification are expressed in the same progenitors.
Galina Dvoriantchikova, Isabel Perea-Martinez, Steve Pappas, Ariel Faye Barry, Dagmara Danek, Xenia Dvoriantchikova, Daniel Pelaez, Dmitry Ivanov   +7 more
doaj   +1 more source

A transition zone enriched WIF1+ basal cell subtype is associated with benign prostatic hyperplasia

The Journal of Pathology, EarlyView.
Abstract The cellular composition and disease susceptibilities of the distinct zones of the human prostate remain incompletely understood. Benign prostatic hyperplasia (BPH) is a common condition that causes widespread morbidity and is nearly exclusively localized to the transition zone (TZ).
Rulin Wang, Qizhi Zheng, Mindy K Graham, Ajay Vaghasia, Jianyong Liu, Jordan Gregg, Tracy Jones, Anuj Gupta, Nicole Castagna, Yan Zhang, Kornel Schuebel, Jennifer Meyers, Alyza Skaist, Dixie Hoyle, Jasmine Kung, Jessica Hicks, Alok Mishra, Yuhan Yang, William G Nelson, Angelo M De Marzo, Srinivasan Yegnasubramanian   +20 more
wiley   +1 more source

PPM1G‒MET axis sustains AKT signaling to drive Twist‐associated EMT and drug resistance in hepatocellular carcinoma

VIEW, EarlyView.
Hepatocellular carcinoma (HCC) is frequently resistant to targeted therapies. We identify protein phosphatase Mg2+/Mn2+‐dependent 1G (PPM1G) as a key phosphatase that stabilizes mesenchymal‐epithelial transition factor (MET) by inhibiting its ubiquitination, thereby sustaining protein kinase B (AKT) signaling and promoting Twist‐mediated epithelial ...
Weixun Wu, Songbin Lin, Cong Zhou, Jinwu Hu, Kun Liu, Yongfeng Xu, Zhenbin Ding, Mengting Luo, Bo Hu   +8 more
wiley   +1 more source

Notch3 Receptor : Activation Mechanism and Association with Ovarian Cancer [PDF]

, 2017
The Notch signaling influences a wide spectrum of cell fate decisions, both during development and in the adult organisms. This pleiotropic role of Notch signaling in humans is attributed partially to the presence of four Notch receptors and many ...
Gera, Sakshi
core  

Framework for headache management in pediatric patients with stroke and cerebrovascular lesions: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To present a practical, evidence‐based framework for the management of headache disorders in pediatric patients with prior stroke or underlying cerebral vascular lesions, with particular attention to safety and efficacy of pharmacologic and non‐pharmacologic therapies.
Allison C. Hyland, Samuel J. Belfer, Christine K. Fox, Samantha L. Irwin, Rachel Vassar, Ann Oh, Sruthi Ilangovan, Amy A. Gelfand   +7 more
wiley   +1 more source

NOTCH3 as a prognostic biomarker and its correlation with immune infiltration in gastrointestinal cancers

Scientific Reports
NOTCH receptor 3 (NOTCH3) is known to regulate the transcription of oncogenes or tumor suppressor genes, thereby playing a crucial role in tumor development, invasion, maintenance, and chemotherapy resistance.
Jia Xu, Xiao-li Jin, Hao Shen, Xuan-wei Chen, Jin Chen, Hui Huang, Bin Xu, Jian Xu   +7 more
doaj   +1 more source

Poorly differentiated lung adenocarcinomas with concurrent ALK and CD30 expression: a diagnostic pitfall mimicking ALK‐positive anaplastic large‐cell lymphoma

Histopathology, EarlyView.
Poorly differentiated lung adenocarcinomas with concurrent anaplastic lymphoma kinase (ALK) and CD30 expression closely mimic ALK‐positive anaplastic large‐cell lymphoma, creating a significant diagnostic pitfall. Accurate classification requires comprehensive integration of clinical, radiologic, morphologic, immunophenotypic and molecular findings ...
Jietian Jin, Wenjian Cen, Qin Yan, Yangshan Chen, Chaoyun Huang, Yanfeng Feng, Neng Jiang   +6 more
wiley   +1 more source

NOTCH3 expression is linked to breast cancer seeding and distant metastasis

Breast Cancer Research, 2018
Background Development of distant metastases involves a complex multistep biological process termed the invasion-metastasis cascade, which includes dissemination of cancer cells from the primary tumor to secondary organs.
Alexey A. Leontovich, Mohammad Jalalirad, Jeffrey L. Salisbury, Lisa Mills, Candace Haddox, Mark Schroeder, Ann Tuma, Maria E. Guicciardi, Luca Zammataro, Mario W. Gambino, Angela Amato, Aldo Di Leonardo, James McCubrey, Carol A. Lange, Minetta Liu, Tufia Haddad, Matthew Goetz, Judy Boughey, Jann Sarkaria, Liewei Wang, James N. Ingle, Evanthia Galanis, Antonino B. D’Assoro   +22 more
doaj   +1 more source

Single-cell RNA sequencing data analysis suggests the cell–cell interaction patterns of the pituitary–kidney axis

Scientific Reports, 2022
Kidney functions, including electrolyte and water reabsorption and secretion, could be influenced by circulating hormones. The pituitary gland produces a variety of hormones and cytokines; however, the influence of these factors on the kidney has not ...
Yiyao Deng, Jingjing Da, Jiali Yu, Chaomin Zhou, Jing Yuan, Yan Zha   +5 more
doaj   +1 more source

Sex‐Specific Proteomic Profiling Identifies Pregnancy Zone Protein as a Complement‐Linked Marker of Adverse Prognosis in Esophageal Adenocarcinoma

International Journal of Cancer, Volume 159, Issue 10, Page 2595-2605, 15 November 2026.
ABSTRACT Esophageal adenocarcinoma (EAC) exhibits marked male predominance with male‐to‐female ratios reaching 8.5:1, yet the molecular basis underlying this sex disparity remains poorly characterized. We analyzed 92 EAC specimens using mass spectrometry–based proteomics, comprising 47 female and 45 male tumors from treatment‐naïve patients ...
Alexander Quaas, Hanna Schiemann, Su Ir Lyu, Thomas Zander, Axel Hillmer, Hans Schlößer, Christiane J. Bruns, Reinhard Büttner, Bastian Grothey   +8 more
wiley   +1 more source