Results 71 to 80 of about 1,245,456 (166)

Signaling pathways and molecular mechanisms involved in the onset and progression of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL); a focus on Notch3 signaling

The Journal of Headache and Pain
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal-dominantly inherited cerebral small-vessel disease (SVD). CADASIL has diverse clinical features such as migraine with aura, dementia, and
Parasta Heidari, Motahareh Taghizadeh, Omid Vakili   +2 more
doaj   +1 more source

CADASIL: A NOTCH3-associated cerebral small vessel disease

Journal of Advanced Research
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel disease (CSVD), pathologically characterized by a non-atherosclerotic and non-amyloid ...
Lamei Yuan, Xiangyu Chen, Joseph Jankovic, Hao Deng   +3 more
doaj   +1 more source

Genetic Parameters and Genome‐Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single‐Step GBLUP Methodology

Journal of Animal Breeding and Genetics, Volume 143, Issue 5, Page 625-638, September 2026.
ABSTRACT Sheep production contributes to a secure and diverse food and fibre supply in the United States, with growing ethnic diversity strengthening demand. Katahdin is a composite hair‐type sheep breed developed in the United States that has become the most popular breed in many regions of the country and the first one to have genomic selection ...
Alejandra Toro Ospina, Ronald M. Lewis, Bradley A. Freking, Joan M. Burke, Thomas W. Murphy, Carrie S. Wilson, Luiz F. Brito   +6 more
wiley   +1 more source

An adult patient with pulmonary arterial hypertension, a NOTCH3 mutation, and leflunomide exposure

Pulmonary Circulation
Pulmonary arterial hypertension (PAH) is a poorly understood disease of the small pulmonary arteries. Pulmonary vascular remodeling and progressively rising pulmonary vascular resistance are hallmarks of the disease that ultimately result in right heart ...
Elizabeth G. Fenner, Catherine E. Simpson   +1 more
doaj   +1 more source

The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo.

, 2007
Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy (CADASIL) is the most prominent known cause of inherited stroke and vascular dementia in human adult. The disease gene, NOTCH3, encodes a transmembrane receptor
Babinet, C, Cohen, Tannoudji M, Souilhol, C, Gridley, T, Lemaire, B, Joutel, A, Monet, M, Langa, F, Tournier, Lasserve E, Domenga, V   +9 more
core   +1 more source

Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries.: Notch3 and vascular tone [PDF]

, 2008
International audienceOBJECTIVE: Notch3, a member of the evolutionary conserved Notch receptor family, is primarily expressed in vascular smooth muscle cells.
D. Henrion, Pinaud, Frédéric, Henrion, Daniel, Bocquet, Arnaud, E. Vessieres, V. Domenga, C. Baufreton, Vessières, Emilie, Belin de Chantemèle, Eric,, K. Retailleau, A. Bocquet, L. Loufrani, B. Lemaire, Belin de Chantemèle, Eric, J., Domenga, Valérie, Lemaire, Barbara, F. Pinaud, Joutel, Anne, Loufrani, Laurent, A. Joutel, Guihot, Anne-Laure, E.J. Belin de Chantemèle, Retailleau, Kevin, Baufreton, Christophe, A.L. Guihot   +24 more
core   +1 more source

FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal

Stem Cell Reports, 2014
Skeletal muscle stem cells, or “satellite cells” (SCs), are required for the regeneration of damaged muscle tissue. Although SCs self-renew during regeneration, the mechanisms that govern SC re-entry into quiescence remain elusive.
Suchitra D. Gopinath, Ashley E. Webb, Anne Brunet, Thomas A. Rando   +3 more
doaj   +1 more source

Two novel mutations and a previously unreported intronic polymorphism in the NOTCH3 gene [PDF]

, 2012
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary disease of small vessel caused by mutations in the NOTCH3 gene (NCBI Gene ID: 4854) located on chromosome 19p13.1.
Griffiths, L.R., Menon, S., Maksemous, N, Roy, Bishakha, Smith, Robert, Smith, R.A., Griffiths, Lyn, Maksemous, N., Davies, G., Roy, B, Davis, Gail, Smith, RA, Griffiths, LR, Menon, S, Roy, B., Davies, G, Menon, Saras, Maksemous, Neven   +17 more
core   +1 more source

Hypoxia regulates Notch-3 mRNA and receptor activation in prostate cancer cells

Heliyon, 2016
The Notch-3 receptor is a recognized key regulator of vascular responses and is increasingly associated with tumorigenesis. Hypoxia-inducible factors activate specific signaling pathways such as Notch in a number of cellular models.
Armelle Meunier, Angela Nilda Flores, Niamh McDermott, Karla Rivera-Figueroa, Antoinette Perry, Thomas Lynch, Kathrine Røe Redalen, Laure Marignol   +7 more
doaj   +1 more source

Characterization of activating mutations of NOTCH3 in T cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies

, 2016
Notch receptors have been implicated as oncogenic drivers in several cancers, the most notable example being NOTCH1 in T-cell acute lymphoblastic leukemia (T-ALL).
Weinstock, David, Aster, Jon, Buckler, Alan, Jones, Michael D., Hu, Tiancen, London, Anne, LeMotte, Peter, Jenkins, David, Firestone, Brant, Jaehrling, Jan, Bernasconi-Elias, Paula, Fryer, Christy J., Nolin, Erin, Kluk, Michael, Ettenberg, Seth, Weinberg, Olga, Choi, Sung Hee, Slocum, Kelly, Weinstock, David M., Gans, Sara, Thiel, Phillip, Goetcshkes, Margaret, Jones, Michael, Christodoulou, Alexandra, Kluk, Michael J., Ettenberg, Seth A., Fryer, Christy, Petropoulos, Konstantin, Ponsel, Dirk, Kurth, Esther, Deplazes-Lauber, Joelle, Capodieci, Paola, Blacklow, Stephen   +32 more
core   +1 more source