Results 81 to 90 of about 1,245,456 (166)

Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. [PDF]

, 2014
The Notch3 signaling pathway is thought to play a critical role in cancer development, as evidenced by the Notch3 amplification and rearrangement observed in human cancers.
Bin Guan, Tian-Li Wang, Ie-Ming Shih (49189), Heng Zhu, Bin Guan (651949), Seth Blackshaw (1586), Alexander Stoeck, Ren-Chin Wu, Seth Blackshaw, Jin-Gyoung Jung, Alexander Stoeck (167820), Jin-Gyoung Jung (651948), Ren-Chin Wu (167828), Tian-Li Wang (49187), Ie-Ming Shih, Heng Zhu (50460)   +15 more
core   +1 more source

Genetic study of the NOTCH3 gene in CADASIL patients [PDF]

, 2019
Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic, hereditary, neurological syndrome characterized by small vessel disease (SVD), stroke, vascular cognitive impairment and ...
Sanati, Mohammad Hossein, Fazeli, Seyed Abolhassan Shahzadeh, Mirzayee, Zahra, Tarzjani, Seyedeh Parisa Chavoshi   +3 more
core  

Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway

Frontiers in Pharmacology
BackgroundPulmonary arterial hypertension (PAH) exhibits significant gender differences in prognosis, with male patients typically showing worse outcomes than females.
Jiayan Sun, Jiayan Sun, Jiayan Sun, Jiancheng Lin, Jiancheng Lin, Jiancheng Lin, Di Yin, Di Yin, Di Yin, Zetao Pan, Zetao Pan, Zetao Pan, Yuheng Ye, Yuheng Ye, Yuheng Ye, Yi Wang, Yi Wang, Yi Wang, Xiaowan Wang, Xiaowan Wang, Xiaowan Wang, Qiang Guo, Qiang Guo, Qiang Guo, Qiang Guo   +24 more
doaj   +1 more source

Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation

Molecular Cancer, 2011
Background Pancreas cancer is one of most aggressive human cancers with the survival rate for patients with metastatic pancreas cancer at 5-6 months. The poor survival demonstrates a clear need for better target identification, drug development and new ...
Vo Kevin, Amarasinghe Barushi, Washington Kay, Gonzalez Adriana, Berlin Jordan, Dang Thao P   +5 more
doaj   +1 more source

Human peripheral blood lymphocytes and fibroblasts as Notch3 expression models.

, 2012
Notch3 is a single pass transmembrane protein belonging to the Notch receptor family. Notch proteins are involved in a very conserved signaling system (Notch signaling) with a broad spectrum of functions, from cell proliferation and differentiation to ...
FEDERICO, ANTONIO, Giuseppe Di Maio, Ermelinda Tarquini, Anna Onnis, RADI, ELENA, Antonio Federico, LEONCINI, LORENZO, Silvia Bianchi, FORMICHI, PATRIZIA, TARQUINI, ERMELINDA, DI MAIO, GIUSEPPE, Patrizia Formichi, Onnis A, BIANCHI, SILVIA, Elena Radi, Lorenzo Leoncini   +15 more
core   +1 more source

Role of Notch gene receptors as prognostic biomarkers in colorectal cancer

Scientific Reports
The incidence of colorectal cancer (CRC) is increasing across the world, especially in younger age groups and the Indian subcontinent. Dysregulation in Notch pathway genes and their Single Nucleotide Polymorphism (SNPs) can potentially lead to aberrant ...
Abhay Kumar Sharma, Nimisha Nimisha, Arun Kumar, Apurva Apurva, Abhishek Kumar, Ejaj Ahmad, Asgar Ali, Birendra Prasad, Sundeep Singh Saluja   +8 more
doaj   +1 more source

Isolation and characterization of a new basal-like luminal progenitor in human breast tissue

Stem Cell Research & Therapy, 2019
Background Adult stem cells and progenitors are responsible for breast tissue regeneration. Human breast epithelial progenitors are organized in a lineage hierarchy consisting of bipotent progenitors (BPs), myoepithelial- and luminal-restricted ...
Vasudeva Bhat, Victoria Lee-Wing, Pingzhao Hu, Afshin Raouf   +3 more
doaj   +1 more source

Unraveling the role of NOTCH3 dysfunction in disease and for therapy development : a focus on CADASIL

, 2021
The Notch signaling pathway, including the Notch3 receptor, is involved in many pivotal contexts of cell signaling and cell fate determination processes during development and in adulthood.
Daniel Oliveira (18652180)
core   +1 more source

Advances in induced pluripotent stem cell-based disease modeling for rare neurodegenerative disease: A narrative review [PDF]

Precision and Future Medicine
Understanding the genetic basis and pathomechanisms underlying dementia arising from single-gene mutations is crucial to expand our knowledge in the field of dementia research. In this review, we comprehensively summarize the results of existing research
Seung-yeon Lee, Hyo Jin Son, Sang Won Seo, Duk L. Na, Hee Jin Kim   +4 more
doaj   +1 more source

易误诊为多发性硬化的伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病1例报道A Case Report of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Easily Misdiagnosed as Multiple Sclerosis

Zhongguo cuzhong zazhi
伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy，CADASIL）是一种常染色体显性遗传性脑小血管疾病。多发性硬化是一种中枢神经系统的炎症性脱髓鞘疾病。两者在临床表现和影像学特征上有较多类似之处，易造成误诊。本文报道１例因颅内和脊髓同时发生病变，最初诊断为多发性硬化，最终经基因检测明确诊断为Notch受体3（Notch ...
吴慧敏, 游咏, 陈斌WU Huimin, YOU Yong, CHEN Bin
doaj   +1 more source