Results 91 to 100 of about 1,245,456 (166)

Pathological Notch3 aggregation [PDF]

, 2016
Cerebral small vessel disease (SVD), characterized by pathological processes that affect structure and function of the brain microvasculature and result in subsequent damage of the cerebral white and deep grey matter, is the main cause for long-term ...
Fresser, Patrizia
core   +1 more source

CADASIL spowodowany stereotypową mutacją p.Arg207Cys w genie NOTCH3

, 2018
Najczęstszą genetycznie uwarunkowaną chorobą małych naczyń związaną z udarami i naczyniopochodnym otępieniem jest mózgowa autosomalna dominująca arteriopatia z podkorowymi zawałami i leukoencefalopatią (cerebral autosomal dominant arteriopathy with ...
Magdalena Obrembska, Łukasz Kępczyński, Karol Jastrzębski, Andrzej Głąbiński, Katarzyna Turoboś, Elżbieta Miller, Agnieszka Sobczyńska-Tomaszewska   +6 more
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Transforming growth factor beta-1 promotes migration and invasion of ovarian epithelial carcinoma cells through TRAF6-mediated activation of Notch3 signaling pathway

Zhongguo aizheng zazhi, 2018
Background and purpose: Abnormal expression and amplification of transforming growth factor beta 1 (TGF-β1) and Notch3 in ovarian carcinoma tissues are associated with metastasis and low survival rate, respectively.
周韵娇, 王婧姝, 梁　凡
doaj  

Synergistic effects of mutation and glycosylation on disease progression

Frontiers in Molecular Biosciences
Glycosylation, a post-translational modification, plays a crucial role in proper localization and function of proteins. It is regulated by multiple glycosyltransferases and can be influenced by various factors.
Shodai Suzuki, Motoyuki Itoh, Motoyuki Itoh, Motoyuki Itoh   +3 more
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NOTCH3 and Pulmonary Arterial Hypertension

NOTCH3 receptor signaling has been linked to the regulation of smooth muscle cell proliferation and the maintenance of smooth muscle cells in an undifferentiated state. Pulmonary arterial hypertension (World Health Organization Group 1 idiopathic disease:
Casandra E. Besse, Cristian Puerta, Nolan M. Winicki, Yu Zhang, Patricia A. Thistlethwaite   +4 more
core   +1 more source

Colon stem cell characterization in normal and tumoral tissues: description of a novel feed-forward circuit of Msi-1 regulation [PDF]

, 2013
Normal tissues are organized in a hierarchical fashion, where rare somatic cells endowed with stem-like properties give origin to a population of differentiated cells forming the bulk of tissue.
Pastò, Anna
core  

Notch3 signaling pathway in cerebral arteries

, 2012
Le gène Notch3 code pour un récepteur transmembranaire hétérodimérique exprimé principalement dans les cellules musculaires lisses des petites artères.
Fouillade, Charles
core  

Notch3, another Notch in T cell development

, 2003
Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or ...
Isabella Screpanti, VACCA, Alessandra, Alberto Gulino, SCREPANTI, Isabella, Diana Bellavia, CAMPESE, Antonio Francesco, GULINO, Alberto, BELLAVIA, Diana, Alessandra Vacca, Antonio F. Campese   +9 more
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Targeting Notch3 signaling in lung cancer

, 2011
Dysregulation of the Notch signaling pathway plays an important role in lung cancer pathobiology. The Notch3 receptor is overexpressed in ∼40% of resected non-small cell lung cancers, and its suppression results in loss of the malignant phenotype both ...
Lin, Luping
core  

The aggressive colorectal cancer subtype marker HTR2B has a dual role depending on the tumor microenvironment

Cell Communication and Signaling
Colorectal cancer (CRC) is the second-third most frequent cancer type in the Western countries, with significant inter- and intra-patient cellular heterogeneity.
Idan Carmi, Adrián Orosz, Szabolcs Hajdó, Anikó Zeöld, Tamás Hegedűs, Dóra Kelemen-Győri, Julianna Pozsár, Tamás Tölgyes, Zoltán Wiener   +8 more
doaj   +1 more source