A gene regulatory network armature for T lymphocyte specification [PDF]
, 2008 Choice of a T lymphoid fate by hematopoietic progenitor cells depends on sustained Notch–Delta signaling combined with tightly regulated activities of multiple transcription factors. To dissect the regulatory network connections that mediate this process,
Bolouri, Hamid +7 more
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FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal
Stem Cell Reports, 2014 Skeletal muscle stem cells, or “satellite cells” (SCs), are required for the regeneration of damaged muscle tissue. Although SCs self-renew during regeneration, the mechanisms that govern SC re-entry into quiescence remain elusive.
Suchitra D. Gopinath +3 more
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Hypoxia regulates Notch-3 mRNA and receptor activation in prostate cancer cells
Heliyon, 2016 The Notch-3 receptor is a recognized key regulator of vascular responses and is increasingly associated with tumorigenesis. Hypoxia-inducible factors activate specific signaling pathways such as Notch in a number of cellular models.
Armelle Meunier +7 more
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Generation and characterization of the human iPSC line IDISi001-A isolated from blood cells of a CADASIL patient carrying a NOTCH3 mutation [PDF]
, 2018 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common form of hereditary stroke disorder.
Aramburu-Núñez, Marta +10 more
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Latent NOTCH3 epitopes unmasked in CADASIL and regulated by protein redox state [PDF]
, 2014 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy CADASIL is caused by more than a hundred NOTCH3 mutations. Virtually all encoded mutant proteins contain an odd number of cysteines. As such, structural changes in
Geschwind, Michael D. +5 more
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Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3. [PDF]
, 2014 Vascular smooth muscle cells (SMCs), which arise from multiple embryonic progenitors, have unique lineage-specific properties and this diversity may contribute to spatial patterns of vascular diseases.
Bernard, William G +5 more
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Isolation and characterization of a new basal-like luminal progenitor in human breast tissue
Stem Cell Research & Therapy, 2019 Background Adult stem cells and progenitors are responsible for breast tissue regeneration. Human breast epithelial progenitors are organized in a lineage hierarchy consisting of bipotent progenitors (BPs), myoepithelial- and luminal-restricted ...
Vasudeva Bhat +3 more
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Zhongguo cuzhong zazhi伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy，CADASIL）是一种常染色体显性遗传性脑小血管疾病。多发性硬化是一种中枢神经系统的炎症性脱髓鞘疾病。两者在临床表现和影像学特征上有较多类似之处，易造成误诊。本文报道１例因颅内和脊髓同时发生病变，最初诊断为多发性硬化，最终经基因检测明确诊断为Notch受体3（Notch ...
吴慧敏, 游咏, 陈斌WU Huimin, YOU Yong, CHEN Bin
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Advances in induced pluripotent stem cell-based disease modeling for rare neurodegenerative disease: A narrative review [PDF]
Precision and Future MedicineUnderstanding the genetic basis and pathomechanisms underlying dementia arising from single-gene mutations is crucial to expand our knowledge in the field of dementia research. In this review, we comprehensively summarize the results of existing research
Seung-yeon Lee +4 more
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Cytoglobin Expression Is Induced in Vascular Smooth Muscle Cells Through Endothelial Cell-Derived Notch Signaling: Implications of a Protective Role in Blood Vessel Function [PDF]
, 2017 Communication between endothelial cells and smooth muscle cells is required for normal blood vessel formation and function. My research focuses on understanding the molecular signaling pathways that govern cell-cell communication and maintain vascular ...
Dammeyer, Kristen
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