Results 131 to 140 of about 11,078 (168)

Abstract 213: Novel NOTCH3 activating mutations identified in tumors sensitive to OMP-59R5, a monoclonal antibody targeting the Notch2 and Notch3 receptors.

Cancer Research, 2013
Abstract The Notch signaling pathway, driven by four Notch family receptors (NOTCH1-4) and five canonical Notch ligands (DLL1, DLL3, DLL4, JAG1, and JAG2) in humans, critically regulates key functions during embryonic development as well as stem cell maintenance and differentiation in adult tissues.
Breanna Wallace, Min Wang, Chris Muriel, Jennifer Cain, Belinda Cancilla, Jalpa Shah, Jie Wei, Austin Gurney, John Lewicki, Aaron Sato, Tim Hoey, Tracy Tang, Ann M. Kapoun   +12 more
openaire   +2 more sources

CADASIL-causing mutations do not alter Notch3 receptor processing and activation

NeuroReport, 2006
CADASIL is associated with mutations in the Notch3 gene but the causal mechanisms of the disorder remain unclear. We studied effects of widely established mutations on Notch3 receptor processing and ligand-mediated activation in stable lines of HEK293 and SH-SY5Y cells expressing either human wild-type or mutant Notch3 receptor.
Low W-C, Santa Y, Takahashi K, Tabira T, Kalaria RN   +4 more
openaire   +3 more sources

The Notch3 Receptor and Its Intracellular Signaling-Dependent Oncogenic Mechanisms

2018
During evolution, gene duplication of the Notch receptor suggests a progressive functional diversification. The Notch3 receptor displays a number of structural differences with respect to Notch1 and Notch2, most of which have been reported in the transmembrane and in the intracellular regions, mainly localized in the negative regulatory region (NRR ...
Diana Bellavia, Saula Checquolo, Rocco Palermo, Isabella Screpanti   +3 more
openaire   +3 more sources

Abstract 1697: Therapeutic targeting the NOTCH3 receptor with antibody drug conjugates

Cancer Research, 2015
Abstract Activation and mutation of the NOTCH signaling pathway is oncogenic in many tissue types and the target of multiple anti-cancer therapies currently in clinical development. Initial therapeutic strategies designed to target the NOTCH pathway have focused on inhibition of aberrant signaling, but can have undesirable side-effects ...
Kenneth G. Geles, Yijie Gao, Latha Sridharan, Andreas Giannakou, Ting-Ting Yamin, Jonathan Golas, Judy Lucas, Manoj Charati, Xiantang Li, Magali Guffroy, Tim Nichols, Kai Wang, Max Follettie, Andreas Maderna, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra   +16 more
openaire   +1 more source

CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk

Experimental Cell Research, 2004
Mutations in the NOTCH3 gene are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary angiopathy leading to strokes and dementia. Pathogenic mutations remove or insert cysteine residues within epidermal growth factor (EGF) repeats in the extracellular domain of the Notch3 ...
Nils, Peters, Christian, Opherk, Simone, Zacherle, Anja, Capell, Petra, Gempel, Martin, Dichgans   +5 more
openaire   +2 more sources

The soluble ligand Y box-1 activates Notch3 receptor by binding to epidermal growth factor like repeats 20-23

Archives of Biochemistry and Biophysics, 2018
The transduction of signal by the Notch receptors to the intracellular domain is highly regulated and relies on binding of the ligands to the Epidermal growth factor Like Repeats (ELRs) of receptor's extracellular domain. Both canonical and non-canonical ligands are known to interact with different ELRs and activate Notch receptors.
Sakshi Gera, Rajan R. Dighe
openaire   +2 more sources

Expression Patterns ofJagged, Delta1, Notch1, Notch2,andNotch3Genes Identify Ligand–Receptor Pairs That May Function in Neural Development

Molecular and Cellular Neuroscience, 1996
Notch genes encode receptors for a signaling pathway that regulates neurogenesis. The DSL (Delta/Serrate/lag-2) genes encode ligands that bind and activate Notch. In situ hybridization was used to determine the spatiotemporal expression of Notch1, Notch2, and Notch3, and the DSL ligands, Jagged and Delta 1, in an effort to identify potential ligand ...
Lindsell, C E, Boulter, J, diSibio, G, Gossler, A, Weinmaster, G   +4 more
openaire   +3 more sources

Characterizing the role of dependence receptor Notch3 in tumour angiogenesis

Caractérisation le rôle du récepteur à dépendance Notch3 dans l'angiogenèse tumorale La voie de signalisation Notch est une signalisation fortement conservée chez les metazoans. Elle régule nombreux processus biologiques, y compris le développement embryonnaire, l'homéostasie tissulaire en particulier dans la décision du destin ...
openaire   +1 more source

[Extracellular Y-box binding protein-1 promotes proliferation and metastasis of HepG2 cells through Notch3 receptor].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2017
To clarify whether HepG2 cells actively secrete Y-box binding protein-1 (YB-1) under stress conditions, and to investigate the pathological significance and mechanism of action of extracellular YB-1.HepG2 cells were stimulated and treated by gradient concentrations of lipopolysaccharide (LPS) and adriamycin, the supernatant of the culture solution was ...
J, Shi, P, Li, L, Zou, P, Chen, L P, Zhang   +4 more
openaire   +1 more source

NO TCH3 variant position is associated with NOTCH3 aggregation load in CADASIL vasculature

Neuropathology and Applied Neurobiology, 2022
Carolina Jost, Remco Hack, Minne Cerfontaine   +2 more
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