Results 101 to 110 of about 16,615 (204)

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Signaling pathways and molecular mechanisms involved in the onset and progression of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL); a focus on Notch3 signaling

The Journal of Headache and Pain
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal-dominantly inherited cerebral small-vessel disease (SVD). CADASIL has diverse clinical features such as migraine with aura, dementia, and
Parasta Heidari, Motahareh Taghizadeh, Omid Vakili   +2 more
doaj   +1 more source

CADASIL: A NOTCH3-associated cerebral small vessel disease

Journal of Advanced Research
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel disease (CSVD), pathologically characterized by a non-atherosclerotic and non-amyloid ...
Lamei Yuan, Xiangyu Chen, Joseph Jankovic, Hao Deng   +3 more
doaj   +1 more source

Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells [PDF]

, 2018
Wiring metabolic signaling circuits in thymocytes Cell differentiation is often accompanied by metabolic changes. Yang et al. report that generation of double-positive (DP) thymocytes from double-negative (DN) cells coincides with dynamic regulation of ...
Awad, Walid, Blanco, Daniel Bastardo, Chen, Wenan, Chen, Xiang, Cheng, Changde, Chi, Hongbo, Dash, Pradyot, Dhungana, Yogesh, Easton, John, Guo, Xi-Zhi J., Kc, Anil, Neale, Geoffrey, Rosencrance, Celeste, Thomas, Paul G., Yang, Kai   +14 more
core   +1 more source

Clinical and Genetic Landscape of Glioblastoma, IDH‐Wildtype With FGFR Gene Family Alterations

Cancer Science, Volume 117, Issue 5, Page 1455-1468, May 2026.
We analyzed 1076 cases of glioblastoma, IDH‐wildtype (GBM, IDH‐wt) using the C‐CAT genomic database to clarify the clinical and genetic features of FGFR alterations. FGFR::TACC fusions and FGFR1 mutations were identified in distinct subsets and were associated with unique co‐mutation patterns.
Yasuhito Kegoya, Yoshihiro Otani, Ryo Mizuta, Ryosuke Ikemachi, Mako Kamiura, Joji Ishida, Shinichi Toyooka, Daisuke Ennishi, Shuta Tomida, Shota Tanaka   +9 more
wiley   +1 more source

An adult patient with pulmonary arterial hypertension, a NOTCH3 mutation, and leflunomide exposure

Pulmonary Circulation
Pulmonary arterial hypertension (PAH) is a poorly understood disease of the small pulmonary arteries. Pulmonary vascular remodeling and progressively rising pulmonary vascular resistance are hallmarks of the disease that ultimately result in right heart ...
Elizabeth G. Fenner, Catherine E. Simpson   +1 more
doaj   +1 more source

Cannabidiol stimulates AML-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner [PDF]

, 2015
Glioma stem-like cells (GSCs) correspond to a tumor cell subpopulation, involved in glioblastoma multiforme (GBM) tumor ini- tiation and acquired chemoresistance.
Amantini, Consuelo, Liberati, Sonia, Morelli, MARIA BEATRICE, Nabissi, Massimo, Pallini, Roberto, Ricci Vitiani, Lucia, Santoni, Giorgio, Santoni, Matteo   +7 more
core   +2 more sources

Intra‐Tissue Bacteriome and Cellular Profiles in Periodontal Granulation Tissue From Osseous Defects and Extraction Sockets

Journal of Clinical Periodontology, Volume 53, Issue 5, Page 806-820, May 2026.
ABSTRACT Aim To investigate the intra‐tissue bacteriome and cell profiles within periodontal granulation tissue (PGT) for exploring the biological essence and translational potentials. Materials and Methods PGT samples were collected from 49 patients with severe periodontitis—including those from osseous defects (GT) during periodontal surgery ...
Tianfan Cheng, Tianle Li, Tsz Yung Wong, Beibei Chen, Chongshan Liao, Xun Ding, Hui Chen, Wei Qiao, George Pelekos, Lijian Jin   +9 more
wiley   +1 more source

Purification and Transcriptomic Characterization of Hypertrophied Hepatic Stellate Cells From CDAHFD Mouse Liver

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The purification protocol for hypertrophied hepatic stellate cells (hypHSCs) developed in this study, using fibrotic and steatotic mouse livers (CDAHFD model), made it possible to obtain a high‐purity hypHSC preparation for transcriptomic analysis.
Marion Heckmann, Nour‐El‐Houda Djerir, Keola Greliche, Pierre‐Henri Commere, Julien Fernandes, Guillaume Sarrabayrouse, Bernard Hainque, Pascal Bigey, Virginie Escriou, Céline Hoffmann   +9 more
wiley   +1 more source