Results 61 to 70 of about 1,245,456 (166)

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Protein aggregates containing wild-type and mutant NOTCH3 are major drivers of arterial pathology in CADASIL

The Journal of Clinical Investigation
Loss of arterial smooth muscle cells (SMCs) and abnormal accumulation of the extracellular domain of the NOTCH3 receptor (Notch3ECD) are the 2 core features of CADASIL, a common cerebral small vessel disease caused by highly stereotyped dominant ...
Nicolas Dupré, Florian Gueniot, Valérie Domenga-Denier, Virginie Dubosclard, Christelle Nilles, David Hill-Eubanks, Christelle Morgenthaler-Roth, Mark T. Nelson, Céline Keime, Lydia Danglot, Anne Joutel   +10 more
doaj   +1 more source

Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures

Stem Cell Reports, 2019
Summary: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most common form of genetic stroke and vascular dementia syndrome resulting from mutations in NOTCH3.
Joseph Kelleher, Adam Dickinson, Stuart Cain, Yanhua Hu, Nicola Bates, Adam Harvey, Jianzhen Ren, Wenjun Zhang, Fiona C. Moreton, Keith W. Muir, Christopher Ward, Rhian M. Touyz, Pankaj Sharma, Qingbo Xu, Susan J. Kimber, Tao Wang   +15 more
doaj   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing

, 2007
Constitutive activation of the transmembrane receptor, Notch3, and loss of function of the hematopoietic transcription repressor, Ikaros (IK), play direct roles in T-cell differentiation and leukemogenesis that are dependent on pre-T-cell receptor (pre ...
GRAZIOLI, PAOLA, Marco Mecarozzi, Isabella Screpanti, Claudio Talora, Diana Bellavia, TALORA, Claudio, BELLAVIA, Diana, FRATI, Luigi, Alberto Gulino, SCREPANTI, Isabella, Paola Grazioli, Luigi Frati, Antonio F Campese, CAMPESE, Antonio Francesco, GULINO, Alberto   +14 more
core   +1 more source

Notch3 Maintains Luminal Phenotype and Suppresses Tumorigenesis and Metastasis of Breast Cancer via Trans-Activating Estrogen Receptor-α [PDF]

, 2017
The luminal A phenotype is the most common breast cancer subtype and is characterized by estrogen receptor α expression (ERα). Identification of the key regulator that governs the luminal phenotype of breast cancer will clarify the pathogenic mechanism ...
Cai-Wen Du, Du, Cai-Wen, Li, Yao-Chen, Zhang, Guo-Jun, Wei, Xiao-Long, Dou, XW, Chen, Chun-Fa, Zhang, Yong-Qu, Tian, Jie, Xiao-Long Wei, Wei, XL, Chen, M, Hao-Yu Lin, Tian, J, Lin, Hao-Yu, Xiao-Wei Dou, Bai, JW, Du, CW, Li, YC, Zhang, GJ, Yao-Chen Li, Guo-Jun Zhang, Min Chen, Jing-Wen Bai, Dou, Xiao-Wei, Yuan-Ke Liang, Lin, HY, Zhang, YQ, Bai, Jing-Wen, Yong-Qu Zhang, Kwan Man, Man, K, Chun-Fa Chen, Jie Tian, Liang, Yuan-Ke, Man, Kwan, Chen, CF, Chen, Min, Liang, YK   +38 more
core   +2 more sources

Coordinated inflammatory macrophage and vascular smooth muscle cell remodeling signatures in human atherosclerosis: An integrative single‐cell and bulk transcriptomic analysis

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Integrative single‐cell and bulk transcriptomic analyses identified a highly inflammatory macrophage state and a vascular smooth muscle cell (VSMC) remodeling continuum in human atherosclerotic plaques. Candidate ligand‐receptor and ligand‐associated target gene expression patterns linked inflammatory macrophage activation with osteogenic/modulated ...
Xinyu Dong, Xuesong Hu, Qi Liu, Yuhao Dong, Yan Xuan, Muning Wang, Siyao Chang, Tianyi Lu, Zhiyang Han   +8 more
wiley   +1 more source

Non-canonical NOTCH3 signalling limits tumour angiogenesis.

, 2017
Notch signalling is a causal determinant of cancer and efforts have been made to develop targeted therapies to inhibit the so-called canonical pathway.
Shuheng Lin, Benjamin Gibert, Nicolas Gadot, Mehlen, Patrick, Bulusu, Sirisha, Patrick Mehlen, Ducarouge, Benjamin, Sirisha Bulusu, Pierre Saintigny, Negulescu, Ana, Jean-Guy Delcros, Nicolas Rama, Lin, Shuheng, Ana Negulescu, Gadot, Nicolas, Saintigny, Pierre, Delcros, Jean-Guy, Meurette, Olivier, Gibert, Benjamin, Treilleux, Isabelle, Benjamin Ducarouge, Rama, Nicolas, Olivier Meurette, Isabelle Treilleux   +23 more
core   +1 more source

Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment

MedComm, Volume 7, Issue 9, September 2026.
Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Weiwei Lu, Yuan Zhang, Chen Shi, Yu Tao, Shaoxin Li, Yufang Sun, Fuhai Ji, Dongsheng Jiang, Terrance P. Snutch, Jin Tao   +9 more
wiley   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, Volume 15, Issue 3, Page 206-226, September 2026.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source