Results 11 to 20 of about 16,615 (204)

The Relationship between TSG101 Protein and Notch3 Receptor in Lung Cancer

Chinese Journal of Lung Cancer, 2009
Background and objective TSG101 protein is one of the key factors in Endosomal sorting pathway. The abnormality of this pathway could decrease degradation of Notch receptor which leads to disorder of cell differentiation and development in drosophila. In
Jiahui CHANG, Ping LU, Cunwei CAI,, Fei LI, Zhiyong ZHONG, Daorong ZHANG   +5 more
doaj   +2 more sources

Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression. [PDF]

J Am Soc Nephrol, 2020
Significance StatementIn patients with CKD, receptor Notch3 is strongly upregulated. Conversely, in experimental kidney disease models,Notch3deficiency protects from organ damage. To determine whether Notch3 on immune cells or tissue-resident cells participates in the inflammatory response, animals with bone marrow chimerism were generated.
Brandt S, Ballhause TM, Bernhardt A, Becker A, Salaru D, Le-Deffge HM, Fehr A, Fu Y, Philipsen L, Djudjaj S, Müller AJ, Kramann R, Ibrahim M, Geffers R, Siebel C, Isermann B, Heidel FH, Lindquist JA, Mertens PR.   +18 more
europepmc   +6 more sources

Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway

Frontiers in Pharmacology
BackgroundPulmonary arterial hypertension (PAH) exhibits significant gender differences in prognosis, with male patients typically showing worse outcomes than females.
Jiayan Sun, Jiayan Sun, Jiayan Sun, Jiancheng Lin, Jiancheng Lin, Jiancheng Lin, Di Yin, Di Yin, Di Yin, Zetao Pan, Zetao Pan, Zetao Pan, Yuheng Ye, Yuheng Ye, Yuheng Ye, Yi Wang, Yi Wang, Yi Wang, Xiaowan Wang, Xiaowan Wang, Xiaowan Wang, Qiang Guo, Qiang Guo, Qiang Guo, Qiang Guo   +24 more
doaj   +3 more sources

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins [PDF]

Molecular and Cellular Biology, 2014
In mammals, there are four NOTCH receptors and five Delta-Jagged-type ligands regulating many aspects of embryonic development and adult tissue homeostasis. NOTCH proteins are type I transmembrane receptors that interact with ligands on adjacent cells and are activated by regulated intramembrane proteolysis (RIP).
Groot, Arjan J., Habets, Roger, Yahyanejad, Sanaz, Hodin, Caroline M., Reiss, Karina, Saftig, Paul, Theys, Jan, Vooijs, Marc   +7 more
openaire   +3 more sources

The emerging role of NOTCH3 receptor signalling in human lung diseases

Expert Reviews in Molecular Medicine, 2022
Abstract The mammalian respiratory system or lung is a tree-like branching structure, and the main site of gas exchange with the external environment. Structurally, the lung is broadly classified into the proximal (or conducting) airways and the distal alveolar region, where the gas exchange occurs.
Manish Bodas, Bharathiraja Subramaniyan, Harry Karmouty-Quintana, Peter F. Vitiello, Matthew S. Walters   +4 more
openaire   +2 more sources

Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer

Technology in Cancer Research & Treatment, 2023
Background : Notch signaling played a critical role in promoting breast tumorigenesis and progression. However, the role and prognostic value of Notch3 combined with DLL4 expression in breast carcinoma had not been explored.
Lin Wang, Ge Cao, Wei Li, Xiao-Wen Chen, Shi-Shuang Xiong, Ya-Nan Mu, Jin-Fang Jiang, Lan Yang, De-Rui Zhang, Yu-Wen Cao   +9 more
doaj   +1 more source

NOTCH3 limits the epithelial–mesenchymal transition and predicts a favorable clinical outcome in esophageal cancer

Cancer Medicine, 2021
Background Esophageal squamous cell carcinoma (ESCC) is the deadliest of all human squamous cell carcinomas and is characterized by chemotherapy resistance and poor prognosis associated with the epithelial–mesenchymal transition (EMT).
Norihiro Matsuura, Koji Tanaka, Makoto Yamasaki, Kotaro Yamashita, Takuro Saito, Tomoki Makino, Kazuyoshi Yamamoto, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Hidetoshi Eguchi, Hiroshi Nakagawa, Yuichiro Doki   +12 more
doaj   +1 more source

The association between NOTCH3 expression and the clinical outcome in the urothelial bladder cancer patients

Biomolecules & Biomedicine, 2022
Disrupted NOTCH activity is a driving event in urothelial bladder cancer (UBC). After activation by hypoxia, the NOTCH3 receptor participates in tumor cell proliferation, acquisition of the epithelial-mesenchymal transition phenotype, and angiogenesis ...
Ana Ristic Petrovic, Dragana Stokanović, Slavica Stojnev, Milena Potić Floranović, Miljan Krstić, Ivana Djordjević, Aleksandar Skakić, Ljubinka Janković Veličković   +7 more
doaj   +1 more source

The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients [PDF]

Journal of Clinical Investigation, 2000
Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset arteriopathy), which leads to stroke and dementia in humans. CADASIL arteriopathy is characterized by major alterations of vascular smooth muscle cells and the presence of specific granular osmiophilic deposits.
Joutel, A, Andreux, F, Gaulis, S, Domenga, V, Cecillon, M, Battail, N, Piga, N, Chapon, F, Godfrain, C, Tournier-Lasserve, E   +9 more
openaire   +3 more sources

Activation Dynamics and Signaling Properties of Notch3 Receptor in the Developing Pulmonary Artery [PDF]

Journal of Biological Chemistry, 2011
Notch3 signaling is fundamental for arterial specification of systemic vascular smooth muscle cells (VSMCs). However, the developmental role and signaling properties of the Notch3 receptor in the mouse pulmonary artery remain unknown. Here, we demonstrate that Notch3 is expressed selectively in pulmonary artery VSMCs, is activated from late fetal to ...
Shamik, Ghosh, Jesus R, Paez-Cortez, Karthik, Boppidi, Michelle, Vasconcelos, Monideepa, Roy, Wellington, Cardoso, Xingbin, Ai, Alan, Fine   +7 more
openaire   +2 more sources