Results 11 to 20 of about 11,078 (168)

The Relationship between TSG101 Protein and Notch3 Receptor in Lung Cancer

Chinese Journal of Lung Cancer, 2009
Background and objective TSG101 protein is one of the key factors in Endosomal sorting pathway. The abnormality of this pathway could decrease degradation of Notch receptor which leads to disorder of cell differentiation and development in drosophila. In
Jiahui CHANG, Ping LU, Cunwei CAI,, Fei LI, Zhiyong ZHONG, Daorong ZHANG   +5 more
doaj   +2 more sources

Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression. [PDF]

J Am Soc Nephrol, 2020
Significance StatementIn patients with CKD, receptor Notch3 is strongly upregulated. Conversely, in experimental kidney disease models,Notch3deficiency protects from organ damage. To determine whether Notch3 on immune cells or tissue-resident cells participates in the inflammatory response, animals with bone marrow chimerism were generated.
Brandt S, Ballhause TM, Bernhardt A, Becker A, Salaru D, Le-Deffge HM, Fehr A, Fu Y, Philipsen L, Djudjaj S, Müller AJ, Kramann R, Ibrahim M, Geffers R, Siebel C, Isermann B, Heidel FH, Lindquist JA, Mertens PR.   +18 more
europepmc   +6 more sources

Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway

Frontiers in Pharmacology
BackgroundPulmonary arterial hypertension (PAH) exhibits significant gender differences in prognosis, with male patients typically showing worse outcomes than females.
Jiayan Sun, Jiayan Sun, Jiayan Sun, Jiancheng Lin, Jiancheng Lin, Jiancheng Lin, Di Yin, Di Yin, Di Yin, Zetao Pan, Zetao Pan, Zetao Pan, Yuheng Ye, Yuheng Ye, Yuheng Ye, Yi Wang, Yi Wang, Yi Wang, Xiaowan Wang, Xiaowan Wang, Xiaowan Wang, Qiang Guo, Qiang Guo, Qiang Guo, Qiang Guo   +24 more
doaj   +3 more sources

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild-Type Receptors: Identification of Highly Selective Inhibitors That Block the Process. [PDF]

FASEB J
ABSTRACT Cerebral autosomal dominant arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL) is a monogenic autosomal dominant small vessel disease clinically characterized by a broad spectrum of symptoms including recurrent ischemic strokes, cognitive dysfunction, and premature dementia.
Wang H, Liu X, Gravesteijn G, Atella A, Liu J, Rutten JW, Ten Dijke P, Gonçalves MAFV, Lesnik Oberstein SAJ, Baker DA.   +9 more
europepmc   +4 more sources

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins [PDF]

Molecular and Cellular Biology, 2014
In mammals, there are four NOTCH receptors and five Delta-Jagged-type ligands regulating many aspects of embryonic development and adult tissue homeostasis. NOTCH proteins are type I transmembrane receptors that interact with ligands on adjacent cells and are activated by regulated intramembrane proteolysis (RIP).
Groot, Arjan J., Habets, Roger, Yahyanejad, Sanaz, Hodin, Caroline M., Reiss, Karina, Saftig, Paul, Theys, Jan, Vooijs, Marc   +7 more
openaire   +3 more sources

The emerging role of NOTCH3 receptor signalling in human lung diseases

Expert Reviews in Molecular Medicine, 2022
Abstract The mammalian respiratory system or lung is a tree-like branching structure, and the main site of gas exchange with the external environment. Structurally, the lung is broadly classified into the proximal (or conducting) airways and the distal alveolar region, where the gas exchange occurs.
Manish Bodas, Bharathiraja Subramaniyan, Harry Karmouty-Quintana, Peter F. Vitiello, Matthew S. Walters   +4 more
openaire   +2 more sources

The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients [PDF]

Journal of Clinical Investigation, 2000
Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset arteriopathy), which leads to stroke and dementia in humans. CADASIL arteriopathy is characterized by major alterations of vascular smooth muscle cells and the presence of specific granular osmiophilic deposits.
A, Joutel, F, Andreux, S, Gaulis, V, Domenga, M, Cecillon, N, Battail, N, Piga, F, Chapon, C, Godfrain, E, Tournier-Lasserve   +9 more
openaire   +2 more sources

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

EMBO Molecular Medicine, 2022
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease; no preventive or curative therapy is available. CADASIL is caused by mutations in the
Daniel V Oliveira, Kirsten G Coupland, Wenchao Shao, Shaobo Jin, Francesca Del Gaudio, Sailan Wang, Rhys Fox, Julie W Rutten, Johan Sandin, Henrik Zetterberg, Johan Lundkvist, Saskia AJ Lesnik Oberstein, Urban Lendahl, Helena Karlström   +13 more
doaj   +1 more source

Activation Dynamics and Signaling Properties of Notch3 Receptor in the Developing Pulmonary Artery [PDF]

Journal of Biological Chemistry, 2011
Notch3 signaling is fundamental for arterial specification of systemic vascular smooth muscle cells (VSMCs). However, the developmental role and signaling properties of the Notch3 receptor in the mouse pulmonary artery remain unknown. Here, we demonstrate that Notch3 is expressed selectively in pulmonary artery VSMCs, is activated from late fetal to ...
Shamik, Ghosh, Jesus R, Paez-Cortez, Karthik, Boppidi, Michelle, Vasconcelos, Monideepa, Roy, Wellington, Cardoso, Xingbin, Ai, Alan, Fine   +7 more
openaire   +2 more sources

Notch2 and Notch3 function together to regulate vascular smooth muscle development. [PDF]

PLoS ONE, 2012
Notch signaling has been implicated in the regulation of smooth muscle differentiation, but the precise role of Notch receptors is ill defined. Although Notch3 receptor expression is high in smooth muscle, Notch3 mutant mice are viable and display only ...
Qingqing Wang, Ning Zhao, Simone Kennard, Brenda Lilly   +3 more
doaj   +1 more source