Results 11 to 20 of about 16,800 (210)

NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells [PDF]

Cell Reports Medicine, 2021
Summary: Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive.
Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christopher J. O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra   +22 more
doaj   +3 more sources

The Relationship between TSG101 Protein and Notch3 Receptor in Lung Cancer

Chinese Journal of Lung Cancer, 2009
Background and objective TSG101 protein is one of the key factors in Endosomal sorting pathway. The abnormality of this pathway could decrease degradation of Notch receptor which leads to disorder of cell differentiation and development in drosophila. In
Jiahui CHANG, Ping LU, Cunwei CAI,, Fei LI, Zhiyong ZHONG, Daorong ZHANG   +5 more
doaj   +2 more sources

HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36 [PDF]

mBio
Human cytomegalovirus (HCMV) establishes latency in CD34+ hematopoietic progenitor cells (HPCs), where reactivation is intimately linked to cellular differentiation.
Aaron Dirck, Nicole Diggins, Wilma Perez, Christopher Parkins, Michael Daily, Rebekah L. Turner, Luke Slind, Linh Nguyen, Daniel Malouli, Guanming Wu, Meaghan Hancock, Patrizia Caposio   +11 more
doaj   +2 more sources

Is the oxidant/antioxidant status altered in CADASIL patients? [PDF]

PLoS ONE, 2013
The altered aggregation of proteins in non-native conformation is associated with endoplasmic reticulum derangements, mitochondrial dysfunction and excessive production of reactive oxygen species. Cerebral autosomal dominant arteriopathy with subcortical
Jonica Campolo, Renata De Maria, Caterina Mariotti, Chiara Tomasello, Marina Parolini, Marina Frontali, Domenico Inzitari, Raffaella Valenti, Antonio Federico, Franco Taroni, Oberdan Parodi   +10 more
doaj   +9 more sources

CADASIL or NOTCH3 mutaion spectrum diseases? Interpretation of NOTCH3 mutations and clinical heterogeneity in CADASIL [PDF]

Frontiers in Neurology
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant disorder characterized by midlife-onset cerebrovascular disease and dementia.
Yuehui Wang, Yiran Liu, Hongbin Mo, Yue Han, Yuanyuan Jing, Fang Deng   +5 more
doaj   +2 more sources

Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation [PDF]

Molecular Cancer, 2011
Background Pancreas cancer is one of most aggressive human cancers with the survival rate for patients with metastatic pancreas cancer at 5-6 months. The poor survival demonstrates a clear need for better target identification, drug development and new ...
Vo Kevin, Amarasinghe Barushi, Washington Kay, Gonzalez Adriana, Berlin Jordan, Dang Thao P   +5 more
doaj   +2 more sources

Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression. [PDF]

J Am Soc Nephrol, 2020
Significance StatementIn patients with CKD, receptor Notch3 is strongly upregulated. Conversely, in experimental kidney disease models,Notch3deficiency protects from organ damage. To determine whether Notch3 on immune cells or tissue-resident cells participates in the inflammatory response, animals with bone marrow chimerism were generated.
Brandt S, Ballhause TM, Bernhardt A, Becker A, Salaru D, Le-Deffge HM, Fehr A, Fu Y, Philipsen L, Djudjaj S, Müller AJ, Kramann R, Ibrahim M, Geffers R, Siebel C, Isermann B, Heidel FH, Lindquist JA, Mertens PR.   +18 more
europepmc   +6 more sources

Role of Notch gene receptors as prognostic biomarkers in colorectal cancer [PDF]

Scientific Reports
The incidence of colorectal cancer (CRC) is increasing across the world, especially in younger age groups and the Indian subcontinent. Dysregulation in Notch pathway genes and their Single Nucleotide Polymorphism (SNPs) can potentially lead to aberrant ...
Abhay Kumar Sharma, Nimisha Nimisha, Arun Kumar, Apurva Apurva, Abhishek Kumar, Ejaj Ahmad, Asgar Ali, Birendra Prasad, Sundeep Singh Saluja   +8 more
doaj   +2 more sources

Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway

Frontiers in Pharmacology
BackgroundPulmonary arterial hypertension (PAH) exhibits significant gender differences in prognosis, with male patients typically showing worse outcomes than females.
Jiayan Sun, Jiayan Sun, Jiayan Sun, Jiancheng Lin, Jiancheng Lin, Jiancheng Lin, Di Yin, Di Yin, Di Yin, Zetao Pan, Zetao Pan, Zetao Pan, Yuheng Ye, Yuheng Ye, Yuheng Ye, Yi Wang, Yi Wang, Yi Wang, Xiaowan Wang, Xiaowan Wang, Xiaowan Wang, Qiang Guo, Qiang Guo, Qiang Guo, Qiang Guo   +24 more
doaj   +3 more sources

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild-Type Receptors: Identification of Highly Selective Inhibitors That Block the Process. [PDF]

FASEB J
ABSTRACT Cerebral autosomal dominant arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL) is a monogenic autosomal dominant small vessel disease clinically characterized by a broad spectrum of symptoms including recurrent ischemic strokes, cognitive dysfunction, and premature dementia.
Wang H, Liu X, Gravesteijn G, Atella A, Liu J, Rutten JW, Ten Dijke P, Gonçalves MAFV, Lesnik Oberstein SAJ, Baker DA.   +9 more
europepmc   +3 more sources