Results 51 to 60 of about 8,915 (192)
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
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Depression in CADASIL patients [PDF]
Archives of Biological Sciences, 2014 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary neurological disease accompanied by recurrent ischemic events, characterized by the presence of psychiatric disorders.
Lačković Maja +8 more
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Annals of Indian Academy of Neurology, 2016 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant angiopathy caused by a mutation in the notch 3 gene on chromosome 19.
Bhavesh Trikamji +3 more
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Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT CARASIL may present without systemic features, and seizures including status epilepticus can occur as late‐stage complications. Long‐term neurological monitoring is essential even in patients lacking extra‐neurological manifestations.
Mohammad Amin Najafi +5 more
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A heterozygous mutation in NOTCH3 in a Chinese family with CADASIL
Frontiers in Genetics, 2022 Introduction: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal-dominant systemic vascular disease that primarily involves small arteries.
Juyi Li +10 more
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Investigating the effects of NOTCH3 Asian‐specific mutant on blood‐brain‐barrier using patient iPSC‐derived cell types [PDF]
Alzheimers DementAbstract Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), is the genetic form of vascular dementia leading to vascular impairments and cognitive decline. CADASIL is caused by mutations in the NOTCH3 gene which encodes a single‐pass transmembrane receptor. The NOTCH3 mutant (MT) is reported
Lee J, Ng A, Tan E, Zeng L.
europepmc +2 more sources
Stroke, 2009 CADASIL is an early onset small vessel disease and genetic variant of pure subcortical ischemic vascular dementia (SIVD). The condition has been invaluable in defining the profile and neuroimaging correlates of cognitive deficits in pure SIVD. The recent completion of a randomized trial in cognitively impaired CADASIL patients has illustrated the ...
openaire +2 more sources
Arquivos de Neuro-Psiquiatria, 2015 CADASIL is the most common cause of hereditary stroke and vascular dementia. Published information about this disease in South America is scant. We describe clinical and demographic characteristics of 13 patients (10 families) with CADASIL from Argentina.
Maximiliano A Hawkes +7 more
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Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL [PDF]
, 2014 Background and Purpose—White matter hyperintensities (WMH) on MRI are a quantitative marker for sporadic cerebral small vessel disease and are highly heritable.
Adib-Samii, P. +28 more
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Voxel‐Wise Whole‐Brain Analysis in Quantitative Susceptibility Mapping: A Narrative Review
Human Brain Mapping, Volume 47, Issue 3, 15 February 2026.Voxel‐wise QSM enables the detection of subtle susceptibility changes and the exploration of disease associations without relying on predefined regions, making it a valuable tool for studying aging and neurological disorders. This review summarizes the complete workflow of voxel‐wise QSM, highlighting post‐processing steps, key methodological ...
Ying Tang +4 more
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