Results 51 to 60 of about 3,805 (159)

Topography and cognitive impact of brain iron deposition in cerebral amyloid angiopathy: Evidence from 7T quantitative susceptibility mapping

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION While brain iron accumulation has been linked to cognitive impairment in aging and small vessel diseases, its spatial pattern and clinical significance in cerebral amyloid angiopathy (CAA) remain poorly defined. METHODS Quantitative susceptibility mapping (QSM) was used to assess region‐specific iron deposition across cortical ...
Yijun Lin, Yang Du, Guangshuo Li, Bin Gao, Mengyao Li, Liheng Bian, Tao Wu, Xingquan Zhao   +7 more
wiley   +1 more source

Characterization of CADASIL among the Han Chinese in Taiwan: Distinct Genotypic and Phenotypic Profiles.

PLoS ONE, 2015
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is originally featured with a strong clustering of mutations in NOTCH3 exons 3-6 and leukoencephalopathy with frequent anterior temporal pole involvement.
Yi-Chu Liao, Cheng-Tsung Hsiao, Jong-Ling Fuh, Chang-Ming Chern, Wei-Ju Lee, Yuh-Cherng Guo, Shuu-Jiun Wang, I-Hui Lee, Yo-Tsen Liu, Yen-Feng Wang, Feng-Chi Chang, Ming-Hung Chang, Bing-Wen Soong, Yi-Chung Lee   +13 more
doaj   +1 more source

An Integrated QSM‐Radiomics Nomogram With Clinical and Imaging Markers for Stratifying Cognitive Impairment in Hypertension

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
This study developed an integrated nomogram combining QSM‐based radiomics, brain iron deposition, white matter hyperintensity, and clinical markers. This model demonstrated superior performance in stratifying hypertensive cognitive impairment compared to traditional single‐parameter models.
Yu Su, Tingting Liu, Chengjun Dong, Limin Ge, Tianxiang Li, Zhiqing Zhang, Yihan Zhang, Chungao Li, Jie Zhao, Chuansheng Zheng, E. Mark Haacke, Wenjun Wu, Lixia Wang   +12 more
wiley   +1 more source

More than lacunes and leukoencephalopathy: A hemorrhagic stroke in CADASIL

Radiology Case Reports
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small vessel disease caused by mutations in the NOTCH3 gene.
Chaimaa Jabbari, MD, Aya Laridi, MD, Ihssane Laasri, MD, Abdallah Bennasser, MD, ElMahdi Ait Belhaj, MD, Ayman El Farouki, PhD, Jamal El Fenni, PhD   +6 more
doaj   +1 more source

Global Research Trends and Hotspots in Cerebral Small Vessel Disease‐Related Cognitive Impairment: A Bibliometric Analysis (2001–2024)

Brain and Behavior, Volume 16, Issue 1, January 2026.
This bibliometric study systematically analyzed 1074 publications in the field of CSVD‐CI from 2001 to 2024. The research reveals three evolutionary phases and identifies four core research clusters: pathophysiological mechanisms, neuroimaging biomarkers, clinical assessment, and therapeutic interventions.
Kuihua Wang, Xiaohui Ji, Hui Li, Xiaoyang Wang, Xiaoyue Jin, YanJun Lin, Qiao Wang, Haizhen Xu, Jianxin Ye, Xiaoping Cui, Yonghui Liang   +10 more
wiley   +1 more source

Peripheral neuropathy in a case with CADASIL: a case report

BMC Neurology, 2018
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized clinically by central nervous system dysfunctions. It is unclear whether CADASIL is involved in peripheral neuropathy.
Yusuke Sakiyama, Eiji Matsuura, Yoshimitsu Maki, Akiko Yoshimura, Masahiro Ando, Miwa Nomura, Kazuya Shinohara, Ryuji Saigo, Tomonori Nakamura, Akihiro Hashiguchi, Hiroshi Takashima   +10 more
doaj   +1 more source

Assessment of Small Vessel Density Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalophy (CADASIL) by High‐Resolution Black‐Blood MRI

Journal of Magnetic Resonance Imaging, Volume 63, Issue 1, Page 157-168, January 2026.
ABSTRACT Background Direct assessments of cerebral small vessels in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) remain a challenge. Purpose To investigate changes of cerebral small vessels in CADASIL using iso‐0.5 mm black‐blood MRI. Study Type Case control study.
Zidong Yang, Fanhua Guo, Steve Mendoza, Ziyang Huang, Yingying Li, Yunqing Ying, Xin Cheng, Qi Yang, Yonggang Shi, Danny J. J. Wang   +9 more
wiley   +1 more source

A Report of Accelerated Coronary Artery Disease Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Case Reports in Cardiology, 2015
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common heritable form of vascular dementia and it is caused by mutations in the NOTCH3 gene.
Courtney B. Rubin, Virginia Hahn, Taisei Kobayashi, Andrew Litwack   +3 more
doaj   +1 more source

Advanced Imaging Applications in Tumefactive Demyelination – Literature Review With an Illustrative Case Report

Clinical Neuroimaging, Volume 3, Issue 1, 2026.
ABSTRACT Background and Purpose Solitary tumefactive demyelinating lesions (TDLs) represent an uncommon but clinically significant manifestation of central nervous system demyelination and pose a major diagnostic challenge due to their radiologic resemblance to high‐grade gliomas, primary central nervous system lymphoma, and other mass‐like lesions ...
Joga Chaganti, Michelle Dellalana, Kiran Talekar, Jay Thakkar, Scott H. Faro   +4 more
wiley   +1 more source

Assessing changes on large cerebral arteries in CADASIL: Preliminary insights from a case-control analysis

Journal of Stroke and Cerebrovascular Diseases
Introduction: Parent large brain arteries are intimately related to their offspring's small arteries. Whether the CADASIL phenotype is confined to small vessels is unclear, and the involvement of large arteries in CADASIL has not been systematically ...
Edgar R. Lopez-Navarro, MD, Silvia V. Mayer, MD, Brenno R. Barreto, MD, Kevin H. Strobino, MPH, Antonio Spagnolo-Allende, MD, Pedro G. Bueno, MD, Kursat Gurel, MD, Khrystyna Kozii, MD, Salwa Rahman, MD, Farid Khasiyev, MD, Jane S. Paulsen, PhD, Jose Gutierrez, MD, MPH   +11 more
doaj   +1 more source