Results 21 to 30 of about 14,274 (181)

Pathological changes and molecular ⁃ genetic mechanisms of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a inherited cerebral small vessel disease caused by Notch3 gene mutation. The molecular⁃genetic mechanisms of CADASIL have been still unclear.
SUN Yuan⁃jing, FAN Yu⁃hua
doaj   +1 more source

The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between Wnt and Notch signaling pathways. [PDF]

PLoS ONE, 2013
Wnt and Notch signaling pathways both play essential roles and interact closely in development and carcinogenesis, but their interaction in non-small-cell lung cancer (NSCLC) is poorly unknown.
Chunyan Li, Siyang Zhang, Yao Lu, Ying Zhang, Enhua Wang, Zeshi Cui   +5 more
doaj   +1 more source

Notch3 Pathway Alterations in Ovarian Cancer [PDF]

Cancer Research, 2014
Abstract The Notch pathway plays an important role in the growth of high-grade serous ovarian (HGS-OvCa) and other cancers, but its clinical and biologic mechanisms are not well understood. Here, we found that the Notch pathway alterations are prevalent and significantly related to poor clinical outcome in patients with ovarian cancer.
Hu, Wei, Liu, Tao, Ivan, Cristina, Sun, Yunjie, Huang, Jie, Mangala, Lingegowda S., Miyake, Takahito, Dalton, Heather J., Pradeep, Sunila, Rupaimoole, Rajesh, Previs, Rebecca A., Han, Hee Dong, Bottsford-Miller, Justin, Zand, Behrouz, Kang, Yu, Pecot, Chad V., Nick, Alpa M., Wu, Sherry Y., Lee, Ju-Seog, Sehgal, Vasudha, Ram, Prahlad, Liu, Jinsong, Tucker, Susan L., Lopez-Berestein, Gabriel, Baggerly, Keith A., Coleman, Robert L., Sood, Anil K.   +26 more
openaire   +5 more sources

Comparison of Longitudinal Changes of Cerebral Small Vessel Disease Markers and Cognitive Function Between Subcortical Vascular Mild Cognitive Impairment With and Without NOTCH3 Variant: A 5-Year Follow-Up Study

Frontiers in Neurology, 2021
No study yet has compared the longitudinal course and prognosis between subcortical vascular cognitive impairment patients with and without genetic component.
Cindy W. Yoon, Young-Eun Kim, Hee Jin Kim, Chang-Seok Ki, Hyejoo Lee, Joung-Ho Rha, Duk L. Na, Sang Won Seo   +7 more
doaj   +1 more source

Notch3 Transactivates Glycogen Synthase Kinase-3-Beta and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer Cells

Cells, 2022
As a critical transformational process in the attributes of epithelial cells, epithelial-to-mesenchymal transition (EMT) is involved in tumor invasion, metastasis, and resistance to treatment, which contributes to the ultimate death of some patients with
Weiling Chen, Yongqu Zhang, Ronghui Li, Wenhe Huang, Xiaolong Wei, De Zeng, Yuanke Liang, Yunzhu Zeng, Min Chen, Lixin Zhang, Wenliang Gao, Yuanyuan Zhu, Yaochen Li, Guojun Zhang   +13 more
doaj   +1 more source

Notch3 Signaling and Aggregation as Targets for the Treatment of CADASIL and Other NOTCH3-Associated Small-Vessel Diseases [PDF]

The American Journal of Pathology, 2021
Mutations in the NOTCH3 gene can lead to small-vessel disease in humans, including the well-characterized cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a condition caused by NOTCH3 mutations altering the number of cysteine residues in the extracellular domain of Notch3.
Dorothee Schoemaker, Joseph F. Arboleda-Velasquez   +1 more
openaire   +2 more sources

NOTCH3 Variants and Risk of Ischemic Stroke

PLoS ONE, 2013
Mutations within the NOTCH3 gene cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). CADASIL mutations appear to be restricted to the first twenty-four exons, resulting in the gain or loss of a cysteine amino acid.
Ross, Owen A., Soto-Ortolaza, Alexandra I., Heckman, Michael G., Verbeeck, Christophe, Serie, Daniel J., Rayaprolu, Sruti, Rich, Stephen S., Nalls, Michael A., Singleton, Andrew, Guerreiro, Rita, Kinsella, Emma, Wszolek, Zbigniew K., Brott, Thomas G., Brown, Robert D., Worrall, Bradford B., Meschia, James F.   +15 more
openaire   +5 more sources

Notch 3 Protein, not its Gene Polymorphism, is Associated with the Chemotherapy Response and Prognosis of Advanced NSCLC Patients

Cellular Physiology and Biochemistry, 2014
Aim: To study the relation of NOTCH3 and its gene polymorphisms with the chemotherapy response and the prognosis of patients with Non-small cell lung cancer (NSCLC).
Chunlei Shi, Jialin Qian, Meili Ma, Yanwei Zhang, Baohui Han   +4 more
doaj   +1 more source

Patient with CADASIL – a diagnostic challenge

Annales Academiae Medicae Silesiensis, 2023
INTRODUCTION: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetically determined and hereditary cerebral small vessel disease caused by mutations in the NOTCH3 gene.
Julia Węgrzynek, Agnieszka Tomaszewska, Angelika Wawrzkiewicz-Witkowska   +2 more
doaj   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source