Results 61 to 70 of about 16,426 (214)

NOTCH3 alterations analysis in malignant glioma samples.

, 2013
(A) NOTCH3 gene expression in representative specimens using quantitative-real time PCR showing high levels of NOTCH3 transcripts in various tumor specimens compared to non-tumor samples (epilepsy biopsies; CNTR).
Timothy C. Ryken (413028), Mahfoud Assem (413029), Mohammad A. Y. Alqudah (413026), Zita A. Sibenaller (413027), Maha S. Al-Keilani (413025), Supreet Agarwal (413024)   +5 more
core   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Vascular NOTCH3 Deposition Load

Neurology Genetics
Vascular NOTCH3 extracellular domain (NOTCH3ECD) deposition is the pathologic hallmark of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We aimed to explore the relationships among the NOTCH3ECD deposition load, the NOTCH3 variant genotype, and cerebral small vessel disease (SVD) severity.Fifty ...
Yu-Wen Cheng, Chih-Hao Chen, Chi-Chao Chao, Ya-Fang Chen, Jiann-Shing Jeng, Sung-Chun Tang, Sung-Tsang Hsieh   +6 more
openaire   +2 more sources

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

A NOTCH3 pathogenic variant influences osteogenesis and can be targeted by antisense oligonucleotides in induced pluripotent stem cells.

PLoS ONE
Lateral Meningocele Syndrome (LMS), a disorder associated with NOTCH3 pathogenic variants, presents with neurological, craniofacial and skeletal abnormalities.
Ernesto Canalis, Jungeun Yu, Lauren Schilling, Paymaan Jafar-Nejad, Michele Carrer   +4 more
doaj   +1 more source

Genetic study of the NOTCH3 gene in CADASIL patients

Egyptian Journal of Medical Human Genetics, 2018
Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic, hereditary, neurological syndrome characterized by small vessel disease (SVD), stroke, vascular cognitive impairment and ...
Seyedeh Parisa Chavoshi Tarzjani, Seyed Abolhassan Shahzadeh Fazeli, Mohammad Hossein Sanati, Zahra Mirzayee   +3 more
doaj   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Characterization of activating mutations of NOTCH3 in T cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies

, 2016
Notch receptors have been implicated as oncogenic drivers in several cancers, the most notable example being NOTCH1 in T-cell acute lymphoblastic leukemia (T-ALL).
Weinstock, David, Aster, Jon, Buckler, Alan, Jones, Michael D., Hu, Tiancen, London, Anne, LeMotte, Peter, Jenkins, David, Firestone, Brant, Jaehrling, Jan, Bernasconi-Elias, Paula, Fryer, Christy J., Nolin, Erin, Kluk, Michael, Ettenberg, Seth, Weinberg, Olga, Choi, Sung Hee, Slocum, Kelly, Weinstock, David M., Gans, Sara, Thiel, Phillip, Goetcshkes, Margaret, Jones, Michael, Christodoulou, Alexandra, Kluk, Michael J., Ettenberg, Seth A., Fryer, Christy, Petropoulos, Konstantin, Ponsel, Dirk, Kurth, Esther, Deplazes-Lauber, Joelle, Capodieci, Paola, Blacklow, Stephen   +32 more
core   +1 more source

Extracellular domain shedding of NOTCH3 during endocytosis associated with heterogeneity between different CADASIL mutant activation mechanisms

Cell Communication and Signaling
Background Mutations in NOTCH3 cause CADASIL, a dominantly inherited condition, linked to recurrent stroke and vascular dementia and associated with accumulation of the ECD of NOTCH3. The latter has a toxic effect on VSMCs.
Samira Hosseini-Alghaderi, Martin Baron
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source