Results 81 to 90 of about 16,426 (214)

Whole Exome Sequencing for Romanian Patients With Neurodevelopmental Disorders Through an International Collaboration

Clinical Genetics, Volume 110, Issue 1, Page 46-63, July 2026.
Whole exome sequencing for Romanian patients with neurodevelopmental disorders through an international collaboration—this study has provided a 50% diagnostic yield for patients with NDDs (27 positive results from 54 patients), supporting the implementation of a WES analysis that can identify SNVs, small INDELs, CNVs, and mitochondrial variants ...
Alexandru Caramizaru, Cristina Durac, Andreea Dumitrescu, Alexandru Calota‐Dobrescu, Alix de Becdelièvre, Marina Konyukh, Denise Cassandrini, Hane Lee, Go Hun Seo, Seung Woo Ryu, Mihai Cucu, Iuliana Manuela Dragomir, Andreea Catana, Homa Tajsharghi, Edoardo Malfatti, Florin Burada, Amelia Dobrescu   +16 more
wiley   +1 more source

Wound Healing and Angiogenic Profiling of Dermal Endothelial Cells Isolated From People With Type 2 Diabetes

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Primary human dermal microvascular endothelial cells (HDMVECs) isolated from individuals with type 2 diabetes (T2D) exhibit dysregulated intrinsic properties, including altered morphology, reduced nitric oxide (NO) availability, and loss of endothelial identity.
James Shadiow, Corey E. Mazo, Pallavi Varshney, Jeongjin J. Kim, Alexander Ahn, Sophie H. Chong, Cory A. Lutz, Crystal M. Holmes, Michael E. Munson, Brian M. Schmidt, Sascha N. Goonewardena, Richard D. Minshall, Thomas P. J. Solomon, Andrew T. Ludlow, Jacob M. Haus   +14 more
wiley   +1 more source

Investigation of the NOTCH3 and TNFSF7 Genes on C19p13 as Candidates for Migraine

, 2008
To investigate the migraine locus around the C19p13 region through analysis of the NOTCH3 gene (C19p13.2- p13.1), previously shown to be a gene involved in CADASIL and the TNFSF7 gene (C19p13), homologous to the ligands of TNF-alpha and TNF-beta, genes
Mick Ovcaric, Tajouri, Lotti, Robert Curtain, Robert A. Smith, Lotti Tajouri, Lyn Griffiths, Smith, Robert, Curtain, Robert, Griffiths, Lyn, Smith, Robert A., Ovcaric, Mick, MacMillan, John, Curtain, Rob, Griffiths, Lyn R., John MacMillan, Ovcaric, Micky, Tajouri, Lotfi   +16 more
core   +1 more source

Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)‐Enriched Extracellular Vesicles That Promote Angiogenesis

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)‐Enriched Extracellular Vesicles that Promote Angiogenesis. The results from this study suggest that EVs isolated from blood immediately after the last bout of endurance exercise training (ExerV) are enriched in antioxidants. ExerVs stimulate vascular growth both in vitro and in 
Alexander M. Fliflet, Ray A. Spradlin, Yanqi Tan, Ane Nishitha Vijayan, Sung Jun Choi, Wei‐Chun Kao, Edita Aksamitiene, Michael Nelappana, Shengzhe Ding, Kai‐Yu Huang, Aryaman Joshi, Nurila Kambar, Tom Bludgen, Madeleine Meehan, Jayna L. Boss, Michael Knipp, Hongming Fan, Cecilia Leal, Roger A. Sunde, Lawrence W. Dobrucki, Stephen A. Boppart, Hyun Joon Kong, Jonathan V. Sweedler, Marni D. Boppart   +23 more
wiley   +1 more source

N3ICD with the transmembrane domain can effectively inhibit EMT by correcting the position of tight/adherens junctions

Cell Adhesion & Migration, 2019
EMT allows a polarized epithelium to lose epithelial integrity and acquire mesenchymal characteristics. Previously, we found that overexpression of the intracellular domain of Notch3 (N3ICD) can inhibit EMT in breast cancer cells. In this study, we aimed
Junyu Tan, Xixun Zhang, Wenjun Xiao, Xiong Liu, Chun Li, Yuxian Guo, Wei Xiong, Yaochen Li   +7 more
doaj   +1 more source

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

Advanced Science, Volume 13, Issue 31, 4 June 2026.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang, Ning Lu, Xin‐Xiu Lin, Xu‐Hui Fang, Yi‐Hui Li, Qing‐Peng Luo, Yu‐Ting Peng, Gil Mor, Ai‐Hua Liao   +8 more
wiley   +1 more source

Human peripheral blood lymphocytes and fibroblasts as Notch3 expression models.

, 2012
Notch3 is a single pass transmembrane protein belonging to the Notch receptor family. Notch proteins are involved in a very conserved signaling system (Notch signaling) with a broad spectrum of functions, from cell proliferation and differentiation to ...
FEDERICO, ANTONIO, Giuseppe Di Maio, Ermelinda Tarquini, Anna Onnis, RADI, ELENA, Antonio Federico, LEONCINI, LORENZO, Silvia Bianchi, FORMICHI, PATRIZIA, TARQUINI, ERMELINDA, DI MAIO, GIUSEPPE, Patrizia Formichi, Onnis A, BIANCHI, SILVIA, Elena Radi, Lorenzo Leoncini   +15 more
core   +1 more source

Regulation of pro-metastatic Notch3 receptor in melanoma [PDF]

, 2023
Metastatic melanoma, which can form distant metastases through the lymphatic vessels, is the deadliest type of all skin cancer. Lymphatic endothelial cells facilitate metastasis of melanoma cells by activating the Notch3 signaling pathway in melanoma ...
Monto, Elisa
core  

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

NOTCH3 and CADASIL syndrome: a genetic and structural overview

EMBnet.journal, 2019
CADASIL syndrome is a rare disease that belongs to a group of disorders called leukodystrophies. It is well established that NOTCH3 gene on chromosome 19 is primarily responsible for the development of the CADASIL syndrome. Herein, an attempt is made to shed light on the actual molecular mechanism underlying CADASIL syndrome, through insights extracted
Eleni Papakonstantinou 1, 2, Flora Bacopoulou 3, Dimitrios Brouzas 4, Vasileios Megalooikonomou 5, Domenica D'Elia 6, Erik Bongcam-Rudloff 7, Dimitrios Vlachakis 1, 2, 8   +9 more
openaire   +5 more sources