Results 81 to 90 of about 17,508 (213)
Advanced Science, Volume 13, Issue 51, 14 September 2026.This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim +8 more
wiley +1 more source
Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.Integrative single‐cell and bulk transcriptomic analyses identified a highly inflammatory macrophage state and a vascular smooth muscle cell (VSMC) remodeling continuum in human atherosclerotic plaques. Candidate ligand‐receptor and ligand‐associated target gene expression patterns linked inflammatory macrophage activation with osteogenic/modulated ...
Xinyu Dong +8 more
wiley +1 more source
Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment
MedComm, Volume 7, Issue 9, September 2026.Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Weiwei Lu +9 more
wiley +1 more source
Regulation of pro-metastatic Notch3 receptor in melanoma [PDF]
, 2023 Metastatic melanoma, which can form distant metastases through the lymphatic vessels, is the deadliest type of all skin cancer. Lymphatic endothelial cells facilitate metastasis of melanoma cells by activating the Notch3 signaling pathway in melanoma ...
Monto, Elisa
core
Notch3 signaling and vascular remodeling in pulmonary arterial hypertension [PDF]
, 2019 Notch signalling is critically involved in vascular morphogenesis and function. Four Notch isoforms (Notch1–4) regulating diverse cellular processes have been identified.
Neves, Karla B. +4 more
core +1 more source
Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives
Precision Medical Sciences, Volume 15, Issue 3, Page 206-226, September 2026.Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley +1 more source
Journal of Animal Breeding and Genetics, Volume 143, Issue 5, Page 625-638, September 2026.ABSTRACT Sheep production contributes to a secure and diverse food and fibre supply in the United States, with growing ethnic diversity strengthening demand. Katahdin is a composite hair‐type sheep breed developed in the United States that has become the most popular breed in many regions of the country and the first one to have genomic selection ...
Alejandra Toro Ospina +6 more
wiley +1 more source
Human peripheral blood lymphocytes and fibroblasts as Notch3 expression models.
, 2012 Notch3 is a single pass transmembrane protein belonging to the Notch receptor family. Notch proteins are involved in a very conserved signaling system (Notch signaling) with a broad spectrum of functions, from cell proliferation and differentiation to ...
FEDERICO, ANTONIO +15 more
core +1 more source
Novel mechanism of resistance to targeted therapies in lung cancer
Molecular & Cellular Oncology, 2019 We have identified a non-canonical role of0 Notch3 in response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy, whereby Notch3 associates with β-catenin, resulting in increased catenin beta-1 (CTNNB1, best known as β ...
Walter Wang +2 more
doaj +1 more source
Clearance of mutant NOTCH3 proteins.
, 2012 293 cells (n = 3 replicate wells per group) were transiently transfected with NOTCH3-luciferase constructs and split into identical 24 well chambers after 24 hours.
He Meng (33363) +6 more
core +1 more source