Results 91 to 100 of about 23,019 (220)

Targeting the Notch receptor dimerization domain to inhibit Notch signalling—A new avenue of therapeutics

The FEBS Journal, EarlyView.
Notch signalling is an evolutionarily conserved signalling pathway that directs cell growth and differentiation across multiple tissue types, and its regulation must be controlled across the lifespan. Aberrant Notch signalling due to genetic mutations that occur within the negative regulatory region of the Notch 1 gene is linked to the development of ...
Gerard F Hoyne
wiley   +1 more source

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

EMBO Molecular Medicine, 2022
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease; no preventive or curative therapy is available. CADASIL is caused by mutations in the
Daniel V Oliveira, Kirsten G Coupland, Wenchao Shao, Shaobo Jin, Francesca Del Gaudio, Sailan Wang, Rhys Fox, Julie W Rutten, Johan Sandin, Henrik Zetterberg, Johan Lundkvist, Saskia AJ Lesnik Oberstein, Urban Lendahl, Helena Karlström   +13 more
doaj   +1 more source

ChIP-BIT: Bayesian inference of target genes using a novel joint probabilistic model of ChIP-seq profiles. [PDF]

, 2015
Chromatin immunoprecipitation with massively parallel DNA sequencing (ChIP-seq) has greatly improved the reliability with which transcription factor binding sites (TFBSs) can be identified from genome-wide profiling studies.
Chen, X, Clarke, R, Jung, JG, Magnani, L, Shajahan-Haq, AN, Shih, IM, Wang, TL, Wang, Y, Xuan, J   +8 more
core   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

The significance of Notch1 compared with Notch3 in high metastasis and poor overall survival in hepatocellular carcinoma. [PDF]

PLoS ONE, 2013
The prognosis for patients with hepatocellular carcinoma (HCC) is poor, and the mechanisms underlying the development of HCC remain unclear. Notch1 and Notch3 may be involved in malignant transformation, although their roles remain unknown.HCC tissues ...
Liang Zhou, Ning Zhang, Wenjie Song, Nan You, Qingjun Li, Wei Sun, Yong Zhang, Desheng Wang, Kefeng Dou   +8 more
doaj   +1 more source

Genetic Parameters and Genome‐Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single‐Step GBLUP Methodology

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Sheep production contributes to a secure and diverse food and fibre supply in the United States, with growing ethnic diversity strengthening demand. Katahdin is a composite hair‐type sheep breed developed in the United States that has become the most popular breed in many regions of the country and the first one to have genomic selection ...
Alejandra Toro Ospina, Ronald M. Lewis, Bradley A. Freking, Joan M. Burke, Thomas W. Murphy, Carrie S. Wilson, Luiz F. Brito   +6 more
wiley   +1 more source

Homozygous NOTCH3 null mutation and impaired NOTCH3 signaling in recessive early‐onset arteriopathy and cavitating leukoencephalopathy

EMBO Molecular Medicine, 2015
Notch signaling is essential for vascular physiology. Neomorphic heterozygous mutations in NOTCH3, one of the four human NOTCH receptors, cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL ...
Tommaso Pippucci, Alessandra Maresca, Pamela Magini, Giovanna Cenacchi, Vincenzo Donadio, Flavia Palombo, Valentina Papa, Alex Incensi, Giuseppe Gasparre, Maria Lucia Valentino, Carmela Preziuso, Annalinda Pisano, Michele Ragno, Rocco Liguori, Carla Giordano, Caterina Tonon, Raffaele Lodi, Antonia Parmeggiani, Valerio Carelli, Marco Seri   +19 more
doaj   +1 more source

Current views on the role of Notch signaling and the pathogenesis of human leukemia [PDF]

, 2011
The Notch signaling pathway is highly conserved from Drosophila to humans and plays an important role in the regulation of cellular proliferation, differentiation and apoptosis.
Joanna Pancewicz, Christophe Nicot
core   +2 more sources

NOTCH3 (Notch homolog 3 (Drosophila)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NOTCH3 (Notch homolog 3 (Drosophila)), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +1 more source

Preterm Birth Increases Susceptibility to Hyperglycemia‐Induced Kidney Injury With Sex‐Specific Differences in Structural and Molecular Responses

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
Preterm mice were delivered at 19 dpc and rendered diabetic with STZ at 6 weeks; kidneys were analysed at 18 weeks. PT‐D females showed increased atubular glomeruli, reduced proximal tubule fraction, higher albuminuria and BUN, and dysregulated fibrotic, vascular, mitochondrial, and Notch pathways.
Rachel K. Dailey, Aleksandra Cwiek, Logan C. Hamil, Sage Timberline, Ayyappa Kumar Sista Kameshwar, Masako Suzuki, Jaya Isaac, Kimberly deRonde, Mark Conaway, Kevin M. Bennett, Edwin J. Baldelomar, Matthew R. Hoch, Kimberly J. Reidy, Jennifer R. Charlton   +13 more
wiley   +1 more source