Results 91 to 100 of about 17,508 (213)

Genetic study of the NOTCH3 gene in CADASIL patients

Egyptian Journal of Medical Human Genetics, 2018
Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic, hereditary, neurological syndrome characterized by small vessel disease (SVD), stroke, vascular cognitive impairment and ...
Seyedeh Parisa Chavoshi Tarzjani, Seyed Abolhassan Shahzadeh Fazeli, Mohammad Hossein Sanati, Zahra Mirzayee   +3 more
doaj   +1 more source

Notch3 signaling pathway in cerebral arteries

, 2012
Le gène Notch3 code pour un récepteur transmembranaire hétérodimérique exprimé principalement dans les cellules musculaires lisses des petites artères.
Fouillade, Charles
core  

NOTCH3 regulates stem-to-mural cell differentiation in infantile hemangioma

, 2018
Infantile hemangioma (IH) is a vascular tumor that begins with rapid vascular proliferation shortly after birth, followed by vascular involution in early childhood.
Kitajewski, Alison A., Shawber, Carrie J., Edwards, Andrew K., Glithero, Kyle, Hardy, Krista, Grzesik, Peter, Kangsamaksin, Thaned, Schonning, Michael, Kitajewski, Jan K., Munabi, Naikhoba C.O., Wu, June K., Tan, Qian Kun   +11 more
core   +1 more source

Myofibrillogenesis Regulator‐1 Regulates the Ubiquitin Lysosomal Pathway of Notch3 Intracellular Domain Through E3 Ubiquitin‐Protein Ligase Itchy Homolog in the Metastasis of Non‐Small Cell Lung Cancer

Advanced Science
Myofibrillogenesis regulator‐1 (MR‐1) is a multifunctional protein involved in the development of various human tumors. The study is the first to report the promoting effect of MR‐1 on the development and metastasis of non‐small cell lung cancer (NSCLC).
Wenxia Zhao, Yang Li, Hanzeng Cheng, Mengyan Wang, Zhishuo Zhang, Meilian Cai, Cong Zhao, Xiaoming Xi, Xiaojun Zhao, Wuli Zhao, Yajun Yang, Rongguang Shao   +11 more
doaj   +1 more source

Notch3 in normal pancreas and PDAC.

, 2013
a) Notch3 in the cytoplasm of normal pancreatic ductal epithelial cells; b) resected PDAC demonstrating strong cytoplasmic Notch3 with some positive nuclei; c) resected PDAC demonstrating largely nuclear stain; d) nuclear stain in an area of perineural ...
Christopher D. Mann (295856), Rajinder Singh (246689), Margaret M. Manson (295864), Christopher Bastianpillai (295858), Friederike Teichert (295862), Elena Karpova (272679), Muhammad M. Masood (295860), David P. Berry (295863), Christopher P. Neal (295859), Donald J. L. Jones (295861)   +9 more
core   +1 more source

Notch3 Functions as a Tumor Suppressor by Controlling Cellular Senescence

, 2013
Notch signaling regulates a broad spectrum of cell fate decisions and differentiation. Both oncogenic and tumor suppressor functions have been shown for Notch signaling.
Cui, Hang, Xu, Mei, Zhang, Hong, Kong, Yahui   +3 more
core   +1 more source

CADASIL or NOTCH3 mutaion spectrum diseases? Interpretation of NOTCH3 mutations and clinical heterogeneity in CADASIL

Frontiers in Neurology
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant disorder characterized by midlife-onset cerebrovascular disease and dementia. It is caused by mutations in the NOTCH3 gene, which affects the amount of cysteine in the extracellular domain (ECD) of the receptor, leading to ...
Wang, Yuehui, Liu, Yiran, Mo, Hongbin, Han, Yue, Jing, Yuanyuan, Deng, Fang   +5 more
openaire   +2 more sources

Hypomorphic NOTCH3 Alleles Do Not Cause CADASIL in Humans

, 2013
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by stereotyped missense mutations in NOTCH3.
Terwindt, Gisela M., Rutten, Julie W., Maat-Kievit, Anneke J., Lesnik Oberstein, Saskia A. J., Lakeman, P., Liem, M.K., Oberstein, S.A.J.L., Terwindt, GM, Dauwerse, Johannes G., Lakeman, P, Duinen, S.G. van, Ginjaar, HB, Vollebregt, E, Pont, M.J., van Duinen, Sjoerd G., Vollebregt, E., Boon, Elles M. J., Vollebregt, Ellen, Oberstein, SAJL, Dauwerse, JG, van Duinen, S.G., Lakeman, Phillis, Liem, MK, Maat-Kievit, JA, Dauwerse, J.G., Rutten, JW, Boon, EMJ, Pont, MJ, Maat-Kievit, A.J., Terwindt, G.M., Rutten, J.W., Liem, Michael K., Boon, E.M.J., Ginjaar, Hendrika B., Pont, Margot J., Ginjaar, H.B., van Duinen, SG   +36 more
core   +1 more source

Notch3 enhances the synergistic effect of all-trans retinoic acid and calcipotriol in pancreatic stellate cell activation

Journal of Translational Medicine
Background Chronic pancreatitis (CP) is characterized by progressive fibrosis and the activation of pancreatic stellate cells (PSCs). As major producers of collagen-I and fibronectin, PSCs play important roles in pancreatic fibrosis, but few studies have
Zheng Lian, Wei-hong Du, Paizi-guli Tusup-han, Yu-xiang Zhang   +3 more
doaj   +1 more source

Overexpression of Notch3 and pS6 Is Associated with Poor Prognosis in Human Ovarian Epithelial Cancer

Mediators of Inflammation, 2016
Notch3 and pS6 play important roles in tumor angiogenesis. To assess the expression of Notch3 and pS6 in Chinese ovarian epithelial cancer patients, a ten-year follow-up study was performed in ovarian epithelial cancer tissues from 120 specimens of human
Zhaoxia Liu, Rongna Yun, Xiaolin Yu, Hui Hu, Genhua Huang, Buzhen Tan, Tingtao Chen   +6 more
doaj   +1 more source