Results 111 to 120 of about 23,019 (220)

Notch3 enhances the synergistic effect of all-trans retinoic acid and calcipotriol in pancreatic stellate cell activation

Journal of Translational Medicine
Background Chronic pancreatitis (CP) is characterized by progressive fibrosis and the activation of pancreatic stellate cells (PSCs). As major producers of collagen-I and fibronectin, PSCs play important roles in pancreatic fibrosis, but few studies have
Zheng Lian, Wei-hong Du, Paizi-guli Tusup-han, Yu-xiang Zhang   +3 more
doaj   +1 more source

Bidirectional Notch signaling and osteocyte-derived factors in the bone marrow microenvironment promote tumor cell proliferation and bone destruction in multiple myeloma [PDF]

, 2016
In multiple myeloma, an overabundance of monoclonal plasma cells in the bone marrow induces localized osteolytic lesions that rarely heal due to increased bone resorption and suppressed bone formation. Matrix-embedded osteocytes comprise more than 95% of
Anderson, Judith, Bellido, Teresita, Carlesso, Nadia, Chirgwin, John M., Cregor, Meloney D., Delgado-Calle, Jesus, Hiasa, Masahiro, Mohammad, Khalid S., Plotkin, Lilian I., Roodman, G. David, Yoneda, Toshiyuki   +10 more
core   +2 more sources

N3ICD with the transmembrane domain can effectively inhibit EMT by correcting the position of tight/adherens junctions

Cell Adhesion & Migration, 2019
EMT allows a polarized epithelium to lose epithelial integrity and acquire mesenchymal characteristics. Previously, we found that overexpression of the intracellular domain of Notch3 (N3ICD) can inhibit EMT in breast cancer cells. In this study, we aimed
Junyu Tan, Xixun Zhang, Wenjun Xiao, Xiong Liu, Chun Li, Yuxian Guo, Wei Xiong, Yaochen Li   +7 more
doaj   +1 more source

Small Vessel Disease in the Heart and Brain: Current Knowledge, Unmet Therapeutic Need and Future Directions [PDF]

, 2019
No abstract ...
Berry, C, Ford, TJ, Hainsworth, AH, Kaski, JC, Pereira, AC, Sidik, N, Touyz, RM   +6 more
core   +2 more sources

Prominent juxtacortical white matter lesion hallmarks NOTCH3-related intracerebral haemorrhage

Stroke and Vascular Neurology
Background and purpose NOTCH3 p.R544C mutation accounts for 5% of spontaneous intracerebral haemorrhage (ICH) in East Asian patients. We investigated whether certain CT features are associated with NOTCH3-related ICH.Methods Patients with spontaneous ICH
Sung-Chun Tang, Jiann-Shing Jeng, Chih-Hao Chen, Yu-Wen Cheng, Ya-Fang Chen, Hao-Chia Hsu   +5 more
doaj   +1 more source

Clinical presentation of Y189C mutation of the NOTCH3 gene in the Polish family with CADASIL

Folia Neuropathologica, 2020
Jolanta Dorszewska, Marta Kowalska, Tomasz Grzegorski, Dorota Dziewulska, Katarzyna Karmelita-Katulska, Anna-Maria Barciszewska, Michał Prendecki, Wojciech Gorczyński, Wojciech Kozubski   +8 more
doaj   +1 more source

Analyses of NOTCH3 variants in Chinese patients with clinically diagnosed Alzheimer's disease and frontotemporal dementia

Alzheimer’s Research & Therapy
Background A pathogenic variant in the NOTCH3 gene has been identified as the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Studies focusing on variants in NOTCH3 in Alzheimer's disease (AD)
Haitian Nan, Min Chu, Ailing Yue, Qianqian He, Jieying Li, Yanchen Liu, Lijun Chi, Xiaoyan Liu, Guoping Peng, Liyong Wu   +9 more
doaj   +1 more source

Notch3 negatively regulates chemoresistance in breast cancers

Tumor Biology, 2016
To define the role of the NOTCH signaling pathway in the development of chemoresistance and the associated epithelial-mesenchymal transition (EMT), we investigated the effect of Notch3 on adriamycin (ADM)-resistant human breast cancer cells (MCF-7/ADM cells). We found that Notch3 was downregulated and involved in the chemoresistance of MCF-7/ADM cells,
Xiaoting Gu, Chunxiao Lu, Dongxu He, Yangfan Lu, Jian Jin, Dequan Liu, Xin Ma   +6 more
openaire   +2 more sources

Myofibrillogenesis Regulator‐1 Regulates the Ubiquitin Lysosomal Pathway of Notch3 Intracellular Domain Through E3 Ubiquitin‐Protein Ligase Itchy Homolog in the Metastasis of Non‐Small Cell Lung Cancer

Advanced Science
Myofibrillogenesis regulator‐1 (MR‐1) is a multifunctional protein involved in the development of various human tumors. The study is the first to report the promoting effect of MR‐1 on the development and metastasis of non‐small cell lung cancer (NSCLC).
Wenxia Zhao, Yang Li, Hanzeng Cheng, Mengyan Wang, Zhishuo Zhang, Meilian Cai, Cong Zhao, Xiaoming Xi, Xiaojun Zhao, Wuli Zhao, Yajun Yang, Rongguang Shao   +11 more
doaj   +1 more source

NOTCH3 Gene [PDF]

, 2020
openaire   +1 more source