Results 101 to 110 of about 16,426 (214)

Inducible T Cell Costimulator Ligand and Inducible T Cell Costimulator Stratification Identify Dichotomous Tumor Microenvironment and Guide Chemo‐Immunotherapy in Small Cell Lung Cancer

MedComm, Volume 7, Issue 6, June 2026.
In small cell lung cancer, high tumor ICOSLG expression drives a microenvironment enriched with immunosuppressive T cells and M2 macrophages. Conversely, ICOSLG low tumors promote CD8+ T cell infiltration. Clinically, high ICOSLG levels predict poor response to immune checkpoint inhibitors and worse survival, whereas low ICOSLG expression indicates ...
Qiji Guo, Yan Chen, Jijun Sun, Hongyi Zhang, Shuyu Ji, Huansha Yu, Lele Zhang, Haiyang Hu, Peng Zhang, Jing Zhang   +9 more
wiley   +1 more source

Notch3 Functions as a Tumor Suppressor by Controlling Cellular Senescence

, 2013
Notch signaling regulates a broad spectrum of cell fate decisions and differentiation. Both oncogenic and tumor suppressor functions have been shown for Notch signaling.
Cui, Hang, Xu, Mei, Zhang, Hong, Kong, Yahui   +3 more
core   +1 more source

Novel mechanism of resistance to targeted therapies in lung cancer

Molecular & Cellular Oncology, 2019
We have identified a non-canonical role of0 Notch3 in response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy, whereby Notch3 associates with β-catenin, resulting in increased catenin beta-1 (CTNNB1, best known as β ...
Walter Wang, David P. Carbone, Rajeswara Rao Arasada   +2 more
doaj   +1 more source

CADASIL or NOTCH3 mutaion spectrum diseases? Interpretation of NOTCH3 mutations and clinical heterogeneity in CADASIL

Frontiers in Neurology
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an autosomal dominant disorder characterized by midlife-onset cerebrovascular disease and dementia. It is caused by mutations in the NOTCH3 gene, which affects the amount of cysteine in the extracellular domain (ECD) of the receptor, leading to ...
Wang, Yuehui, Liu, Yiran, Mo, Hongbin, Han, Yue, Jing, Yuanyuan, Deng, Fang   +5 more
openaire   +2 more sources

Comprehensive Genomic Characterization Between Urothelial Carcinoma Subtypes/Divergent Differentiation (S/DD) and Pure Urothelial Carcinoma Using a Large‐Scale Japanese Genomic Panel Dataset

International Journal of Urology, Volume 33, Issue 6, June 2026.
ABSTRACT Objectives Urothelial carcinoma (UC) is a common malignancy; however, UC subtypes/divergent differentiation (S/DD) accounts for only 10%–20% of overall cases. S/DD's aggressive biological behavior significantly affects its prognosis and therapeutic decision‐making; thus, elucidating its genomic landscape within UC is important.
Go Kobayashi, Yohei Sekino, Shunsuke Miyamoto, Kohei Kobatake, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Testutaro Hayashi, Kazuhiro Sentani, Nobuyuki Hinata   +10 more
wiley   +1 more source

Hypomorphic NOTCH3 Alleles Do Not Cause CADASIL in Humans

, 2013
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by stereotyped missense mutations in NOTCH3.
Terwindt, Gisela M., Rutten, Julie W., Maat-Kievit, Anneke J., Lesnik Oberstein, Saskia A. J., Lakeman, P., Liem, M.K., Oberstein, S.A.J.L., Terwindt, GM, Dauwerse, Johannes G., Lakeman, P, Duinen, S.G. van, Ginjaar, HB, Vollebregt, E, Pont, M.J., van Duinen, Sjoerd G., Vollebregt, E., Boon, Elles M. J., Vollebregt, Ellen, Oberstein, SAJL, Dauwerse, JG, van Duinen, S.G., Lakeman, Phillis, Liem, MK, Maat-Kievit, JA, Dauwerse, J.G., Rutten, JW, Boon, EMJ, Pont, MJ, Maat-Kievit, A.J., Terwindt, G.M., Rutten, J.W., Liem, Michael K., Boon, E.M.J., Ginjaar, Hendrika B., Pont, Margot J., Ginjaar, H.B., van Duinen, SG   +36 more
core   +1 more source

Targeted next generation sequencing identifies novel NOTCH3 gene mutations in CADASIL diagnostics patients

, 2016
BACKGROUND\ud \ud Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic, hereditary, small vessel disease of the brain causing stroke and vascular dementia in adults.
Robert A. Smith, Lyn R. Griffiths, Griffiths, Lyn R., Neven Maksemous, Maksemous, Neven, Larisa M. Haupt, Smith, Robert A., Haupt, Larisa M.   +7 more
core   +1 more source

Analyses of NOTCH3 variants in Chinese patients with clinically diagnosed Alzheimer's disease and frontotemporal dementia

Alzheimer’s Research & Therapy
Background A pathogenic variant in the NOTCH3 gene has been identified as the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Studies focusing on variants in NOTCH3 in Alzheimer's disease (AD)
Haitian Nan, Min Chu, Ailing Yue, Qianqian He, Jieying Li, Yanchen Liu, Lijun Chi, Xiaoyan Liu, Guoping Peng, Liyong Wu   +9 more
doaj   +1 more source

Overexpression of Notch3 and pS6 Is Associated with Poor Prognosis in Human Ovarian Epithelial Cancer

Mediators of Inflammation, 2016
Notch3 and pS6 play important roles in tumor angiogenesis. To assess the expression of Notch3 and pS6 in Chinese ovarian epithelial cancer patients, a ten-year follow-up study was performed in ovarian epithelial cancer tissues from 120 specimens of human
Zhaoxia Liu, Rongna Yun, Xiaolin Yu, Hui Hu, Genhua Huang, Buzhen Tan, Tingtao Chen   +6 more
doaj   +1 more source

Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma.

, 2007
BACKGROUND: Notch signalling is altered in several solid tumours and it plays a role in growth inhibition and apoptosis of hepatocellular carcinoma (HCC)-derived cell lines, bile duct development and hepatocyte regeneration.
GIOVANNINI, CATIA, CHIECO, PASQUALE, GRAZI, GIAN LUCA, Gramantieri L, Ravaioli M, VENTURI, ANNAMARIA, LANZI, ARIANNA, BOLONDI, LUIGI   +7 more
core   +1 more source