Results 101 to 110 of about 17,508 (213)

Prominent juxtacortical white matter lesion hallmarks NOTCH3-related intracerebral haemorrhage

Stroke and Vascular Neurology
Background and purpose NOTCH3 p.R544C mutation accounts for 5% of spontaneous intracerebral haemorrhage (ICH) in East Asian patients. We investigated whether certain CT features are associated with NOTCH3-related ICH.Methods Patients with spontaneous ICH
Sung-Chun Tang, Jiann-Shing Jeng, Chih-Hao Chen, Yu-Wen Cheng, Ya-Fang Chen, Hao-Chia Hsu   +5 more
doaj   +1 more source

Notch3 Is Critical for Proper Angiogenesis and Mural Cell Investment

, 2010
Rationale: The heterotypic interactions of endothelial cells and mural cells (smooth muscle cells or pericytes) are crucial for assembly, maturation, and subsequent function of blood vessels.
Brenda Lilly, Hua Liu, Wenbo Zhang, Ruth B. Caldwell, Simone Kennard   +4 more
core   +1 more source

Clinical presentation of Y189C mutation of the NOTCH3 gene in the Polish family with CADASIL

Folia Neuropathologica, 2020
Jolanta Dorszewska, Marta Kowalska, Tomasz Grzegorski, Dorota Dziewulska, Katarzyna Karmelita-Katulska, Anna-Maria Barciszewska, Michał Prendecki, Wojciech Gorczyński, Wojciech Kozubski   +8 more
doaj   +1 more source

Genetic study of the NOTCH3 gene in CADASIL patients [PDF]

, 2019
Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic, hereditary, neurological syndrome characterized by small vessel disease (SVD), stroke, vascular cognitive impairment and ...
Sanati, Mohammad Hossein, Fazeli, Seyed Abolhassan Shahzadeh, Mirzayee, Zahra, Tarzjani, Seyedeh Parisa Chavoshi   +3 more
core  

The Notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms

, 2018
During evolution, gene duplication of the Notch receptor suggests a progressive functional diversification. The Notch3 receptor displays a number of structural differences with respect to Notch1 and Notch2, most of which have been reported in the ...
Isabella Screpanti, Saula Checquolo, Diana Bellavia, Rocco Palermo   +3 more
core   +1 more source

Rôle de Notch3 dans la microcirculation rénale

, 2009
Notch3 est une protéine membranaire impliquée dans la différenciation des cellules musculaires lisses et la régulation du réflexe myogénique cérébral. L objectif de ce travail est de préciser le rôle de Notch3 dans la microcirculation rénale.
CHATZIANTONIOU, Christos, BOULOS, Nada
core  

Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma.

, 2007
BACKGROUND: Notch signalling is altered in several solid tumours and it plays a role in growth inhibition and apoptosis of hepatocellular carcinoma (HCC)-derived cell lines, bile duct development and hepatocyte regeneration.
GIOVANNINI, CATIA, CHIECO, PASQUALE, GRAZI, GIAN LUCA, Gramantieri L, Ravaioli M, VENTURI, ANNAMARIA, LANZI, ARIANNA, BOLONDI, LUIGI   +7 more
core   +1 more source

An overview of Notch3 function in vascular smooth muscle cells

, 2008
Proteins of the Notch family are cell surface receptors that transduce signals between neighbouring cells. The Notch signalling pathway is highly evolutionarily conserved and critical for cell fate determination during embryonic development, including ...
Baron, Martin; id_orcid, Tao Wang, Dorothy Trump, Trump, Dorothy, Wang, Tao, Martin Baron   +5 more
core   +1 more source

Analyses of NOTCH3 variants in Chinese patients with clinically diagnosed Alzheimer's disease and frontotemporal dementia

Alzheimer’s Research & Therapy
Background A pathogenic variant in the NOTCH3 gene has been identified as the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Studies focusing on variants in NOTCH3 in Alzheimer's disease (AD)
Haitian Nan, Min Chu, Ailing Yue, Qianqian He, Jieying Li, Yanchen Liu, Lijun Chi, Xiaoyan Liu, Guoping Peng, Liyong Wu   +9 more
doaj   +1 more source

Necessity of Notch3 signaling in myofiber maturation in a pluripotent stem cell transplant model

Skeletal Muscle
Background Pluripotent stem cell-derived myogenic progenitors change from an embryonic to a postnatal molecular signature upon engrafting as satellite cells, which coincides with upregulation of Notch3.
Aline M. S. Yamashita, Sarah B. Crist, Bayardo I. Garay, Hyunkee Kim, Karim Azzag, Darko Bosnakovski, Sergio H. D. M. Faria, Juan E. Abrahante, Phablo Abreu, Aaron Ahlquist, Rita C. R. Perlingeiro   +10 more
doaj   +1 more source