Results 151 to 160 of about 69,335 (249)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

High tibial osteotomy achieves unloading of the medial tibiofemoral compartment irrespective of arthritic status or medial collateral ligament release: A biomechanical assessment. [PDF]

J Exp Orthop
Syed H, Mumith A, Wasserstein D, Chandrashekar N, Nauth A, Whyne C, Tomescu S.   +6 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Unilateral Hypoplasia of the Trapezius Muscle in a Female Cadaver. [PDF]

Cureus
Levien A, Savoie AM, Negron K, Jaynes D.
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Intraligamentary anaesthesia: a local anaesthesia technique in equine dentistry. [PDF]

Acta Vet Scand
Teysen S, Demey W, Menzies R, Staszyk C, Birkhed D, Lundström T.   +5 more
europepmc   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Geometric Fidelity of Magnetic Resonance Imaging and Computed Tomography-Derived Virtual 3D Models of Porcine Cadaver Mandibles: Conventional Versus Artificial Intelligence-Based Segmentation. [PDF]

Oral Health Prev Dent
Ritschl LM, Pippich K, Herrmann M, Deppe H, Sculean A, Probst M, Probst FA.   +6 more
europepmc   +1 more source

Anatomical variations of the brachial plexus terminal branches in Ethiopian cadavers

, 1970
Edengenet Guday Demis, Asegedeche Bekele
openalex   +2 more sources

Cone beam CT for perioperative imaging in hearing preservation Cochlear implantation – a human cadaveric study [PDF]

, 2019
Kayvan Nateghifard, David Low, Lola Awofala, Dilakshan Srikanthan, Jafri Kuthubutheen, Michael J. Daly, Harley Chan, Jonathan C. Irish, Joseph Chen, Vincent Lin, Trung Le   +10 more
openalex   +1 more source