Results 151 to 160 of about 121,076 (308)

ACE‐inhibitory peptide Leu‐Tyr‐Ala in skeletal muscle actin exhibits anti‐aging effects through the inhibition of acn‐1 in Caenorhabditis elegans

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Inhibitors of angiotensin‐converting enzyme (ACE) are used in pharmaceuticals and functional foods. Captopril, a well‐known ACE inhibitor, extends the lifespan of the nematode Caenorhabditis elegans. Bioactive peptides derived from food sources are considered safe ACE inhibitors.
Issei Yokoyama, Minori Yamane, Kanaho Watanabe, Abdul Fatah, Yusuke Komiya, Jun Nagasao, Keizo Arihara   +6 more
wiley   +1 more source

Stressed-Induced TMEM135 Protein Is Part of a Conserved Genetic Network Involved in Fat Storage and Longevity Regulation in Caenorhabditis elegans

, 2010
Disorders of mitochondrial fat metabolism lead to sudden death in infants and children. Although survival is possible, the underlying molecular mechanisms which enable this outcome have not yet been clearly identified.
Adams, MR, Silva Avila, Daiana, Elizabeth A Exil, Vernat J Exil, Exil Vernat J., Au Catherine, Exil, VJ, Adams, Margaret R., Benedetto Alexandre, Exil, EA, Aschner, Michael, Margaret R Adams, Elizabeth A. Exil, Michael Aschner, Avila, DS, Silva Avila Daiana, Exil Elizabeth A., Au, Catherine, Exil, Elizabeth A., Alexandre Benedetto, Margaret R. Adams, Aschner, M, Adams Margaret R., Vernat J. Exil, Benedetto, A, Au, C, Benedetto, Alexandre, Catherine Au, Aschner Michael, Exil, Vernat J., Daiana Silva Avila   +30 more
core   +1 more source

Visualizing genomic evolution in Caenorhabditis through WormSynteny

BMC Genomics
Understanding the syntenic relationships among genomes is crucial to elucidate the genomic mechanisms that drive the evolution of species. The nematode Caenorhabditis is a good model for studying genomic evolution due to the well-established biology of ...
Lilly Bouvarel, Dongyao Liu, Chaogu Zheng   +2 more
doaj   +1 more source

Sodium sulfite can reliably induce chemical hypoxia without toxic effects in the model sea anemone species, Exaiptasia diaphana

Limnology and Oceanography: Methods, EarlyView.
Abstract Climate change is accelerating the deoxygenation of aquatic ecosystems, so understanding its effects on biological processes is increasingly critical. An emerging method for inducing hypoxia during experimentation utilizes sodium sulfite (SSI) to scavenge oxygen; however, it remains unclear if hypoxia‐inducing concentrations of SSI are toxic ...
Zhen Qin, Lorenzo Vassura, Bianca A. Parodi, Elise M. J. Laetz   +3 more
wiley   +1 more source

A Reversible Clearing Strategy Enables Robust Label‐Free Phase Imaging of Thick Tissues

Laser &Photonics Reviews, EarlyView.
The principle of a reversible clearing strategy via glycerol and tartrazine solution (GTS) for robust whole‐slide label‐free phase imaging of thick tissue slices via high‐throughput Fourier ptychographic microscopy (FPM) and lensless digital holographic microscopy (LDHM). ABSTRACT Thick biological specimens impose strong scattering and attenuation that
Mikołaj Krysa, Anna Chwastowicz, Małgorzata Lenarcik, Paweł Matryba, Piotr Zdańkowski, Maciej Trusiak   +5 more
wiley   +1 more source

The significance of DAF-16 and its role in the phenotypic covariance of longevity, immunity and stress resistance in the Caenorhabditis nematodes [PDF]

, 2010
Ageing, immunity and stress tolerance are inherent characteristics of all organisms. In animals, these traits are regulated, at least in part, by forkhead transcription factors in response to upstream signals from the Insulin/Insulin–like growth factor ...
Gandhi, Francis Amrit Raj
core  

Presynaptic Congenital Myasthenic Syndromes

Muscle &Nerve, EarlyView.
ABSTRACT Presynaptic congenital myasthenic syndromes (CMS) encompass a large number of rare neurologic disorders caused by impaired release of acetylcholine (ACh) from motor nerve terminals. There are two main groups of presynaptic CMS: one in which the amount of ACh in synaptic vesicles (SV) is diminished and another in which the mechanism of synaptic
Ricardo A. Maselli
wiley   +1 more source

Microbial light-activatable proton pumps as neuronal inhibitors to functionally dissect neuronal networks in C. elegans

, 2012
Essentially any behavior in simple and complex animals depends on neuronal network function. Currently, the best-defined system to study neuronal circuits is the nematode Caenorhabditis elegans, as the connectivity of its 302 neurons is exactly known ...
Hang Lu (151732), Lu, Hang, Liewald, Jana F., Steven J Husson, Alexander Gottschalk, Stirman, Jeffrey N., Jana F Liewald, Jana F. Liewald (140319), Gottschalk, Alexander, Jeffrey N Stirman, Hang Lu, Christian Schultheis (140316), Alexander Gottschalk (129613), Husson, Steven J., Schultheis, Christian, Jeffrey N. Stirman (151729), Christian Schultheis, Steven J. Husson (140318)   +17 more
core   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Fecundity and lifespan manipulations in Caenorhabditis elegans using exogenous peptides

, 2008
In this study using Caenorhabditis elegans, we have been able to suppress (>60%) and enhance (>40%) fecundity (number of offspring) while extending lifespan by a fifth, by administering synthetic peptides to the aqueous medium in ...
Keith G. Davies, Davies, K. G., John E. Hart, Hart, J. E.   +3 more
core   +1 more source