Results 121 to 130 of about 193,403 (293)
Exploration, EarlyView.Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang +4 more
wiley +1 more source
Recent progresses on anti-aging compounds and their targets in Caenorhabditis elegans
Translational Medicine of Aging, 2019 Searching for drugs that extend healthy lifespan and the subsequent analysis of their mechanisms of action is a crucial aspect for aging research. However, identifying both longevity-enhancing drugs and their corresponding targets is challenging.
Eun Ji E. Kim, Seung-Jae V. Lee
doaj
Food Frontiers, Volume 6, Issue 3, Page 1513-1529, May 2025.Olive leaf (OL) extracts were assessed for biomedical and phytochemical profiles. High‐OL extract was the most effective in inhibiting AChE, COX‐2, and iron‐reducing activity. Low‐ and high‐OL extracts showed significant effects against Aβ and tau toxicity in vivo. All extracts modulated redox biology at different levels. Only high‐OL extract prevented
Jose M. Romero‐Marquez +12 more
wiley +1 more source
NRF2 signalling in cytoprotection and metabolism
British Journal of Pharmacology, EarlyView., 2023 The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami +4 more
wiley +1 more source
A phylogeny and molecular barcodes for
BMC Evolutionary Biology, 2011 Background The nematode Caenorhabditis elegans is a major laboratory model in biology. Only ten Caenorhabditis species were available in culture at the onset of this study. Many of them, like C. elegans, were mostly isolated from artificial compost heaps,
Kiontke Karin C +6 more
doaj +1 more source
A Transparent Window into Biology: A Primer on Caenorhabditis elegans
Genetics, 2015 A little over 50 years ago, Sydney Brenner had the foresight to develop the nematode (round worm) Caenorhabditis elegans as a genetic model for understanding questions of developmental biology and neurobiology. Over time, research on C.
A. K. Corsi, B. Wightman, M. Chalfie
semanticscholar +1 more source
Genetics, 2015 Homology-directed repair (HDR) of breaks induced by the RNA-programmed nuclease Cas9 has become a popular method for genome editing in several organisms. Most HDR protocols rely on plasmid-based expression of Cas9 and the gene-specific guide RNAs.
Alexandre Paix +3 more
semanticscholar +1 more source
iMeta, EarlyView.Schematic representation of the design. Tryptophan metabolism is enriched in serum metabolites and gut microbiota of centenarians, potentially contributing to healthy longevity. A key tryptophan metabolite 5‐methoxyindoleacetic acid (5‐MIAA) is linked to the Christensenellaceae R‐7 group and exhibits effects of delaying cell senescence, promoting ...
Xiaorou Qiu +16 more
wiley +1 more source
Mid‐IR Imaging Can Detect Waste Heat Production in the Nematode Caenorhabditis elegans
Journal of Biophotonics, EarlyView.This study explores how the ectothermic invertebrate Caenorhabditis elegans produces waste heat during metabolism using thermal infrared imaging. A new imaging technique was developed to clearly show differences in heat output between living and dead worms.
Ryan A. Merritt +4 more
wiley +1 more source