Results 151 to 160 of about 279,189 (378)
Caenorhabditis elegans as a Model for Microbiome Research
Frontiers in Microbiology, 2017 The nematode Caenorhabditis elegans is used as a central model system across biological disciplines. Surprisingly, almost all research with this worm is performed in the absence of its native microbiome, possibly affecting generality of the obtained ...
Fan Zhang +6 more
semanticscholar +1 more source
Cytoskeleton, EarlyView.ABSTRACT Cells have an intrinsic ability to rapidly respond to environmental change to regulate cell cycle progression and membrane organisation, thereby affecting cell growth and division. The actin cytoskeleton is a highly dynamic complex of proteins that can rapidly reorganise to change the growth pattern of a cell.
Holly R. Brooker +7 more
wiley +1 more source
Recent progresses on anti-aging compounds and their targets in Caenorhabditis elegans
Translational Medicine of Aging, 2019 Searching for drugs that extend healthy lifespan and the subsequent analysis of their mechanisms of action is a crucial aspect for aging research. However, identifying both longevity-enhancing drugs and their corresponding targets is challenging.
Eun Ji E. Kim, Seung-Jae V. Lee
doaj
CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering
Genetics, 2016 The advent of genome editing techniques based on the clustered regularly interspersed short palindromic repeats (CRISPR)–Cas9 system has revolutionized research in the biological sciences. CRISPR is quickly becoming an indispensible experimental tool for
D. Dickinson, B. Goldstein
semanticscholar +1 more source
Genetics of Aging in Caenorhabditis elegans
PLoS Genetics, 2007 A dissection of longevity in Caenorhabditis elegans reveals that animal life span is influenced by genes, environment, and stochastic factors. From molecules to physiology, a remarkable degree of evolutionary conservation is seen.
openaire +6 more sources
PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential
Cytoskeleton, EarlyView.ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah +2 more
wiley +1 more source
A phylogeny and molecular barcodes for
BMC Evolutionary Biology, 2011 Background The nematode Caenorhabditis elegans is a major laboratory model in biology. Only ten Caenorhabditis species were available in culture at the onset of this study. Many of them, like C. elegans, were mostly isolated from artificial compost heaps,
Kiontke Karin C +6 more
doaj +1 more source
The embryonic cell lineage of the nematode Halicephalobus gingivalis (Nematoda: Cephalobina: Panagrolaimoidea) [PDF]
, 2007 A
Borgonie, Gaetan, Houthoofd, Wouter
core +2 more sources
Survival assays using Caenorhabditis elegans
Molecules and Cells, 2017 Caenorhabditis elegans is an important model organism with many useful features, including rapid development and aging, easy cultivation, and genetic tractability. Survival assays using C. elegans are powerful methods for studying physiological processes.
Hae-Eun H. Park +2 more
semanticscholar +1 more source
The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts
Cytoskeleton, EarlyView.ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Guadalupe E. Pena +4 more
wiley +1 more source