Results 191 to 200 of about 111,262 (297)

RNA‐Based Therapies for Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri, Sonam Gurung, Roopkatha Ghosh, Philippa B. Mills, Julien Baruteau, Haiyan Zhou   +5 more
wiley   +1 more source

Transcriptomics-Based Toxicological Study of Nickel on <i>Caenorhabditis elegans</i>. [PDF]

Toxics
He Y, Long Y, Wang J, Li Q, Liu B, Li D, Xu S.   +6 more
europepmc   +1 more source

RNA interference and retinoblastoma-related genes are required for repression of endogenous siRNA targets in Caenorhabditis elegans

, 2008
Alla Grishok, Sebastian Hoersch, Phillip A. Sharp   +2 more
openalex   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Single‐cell mitochondrial lineage tracing: Opportunities and challenges

Quantitative Biology, Volume 14, Issue 1, March 2026.
Abstract Lineage tracing using endogenous mitochondrial DNA (mtDNA) variants holds great promise for reconstructing the lineage histories of individual cells, with broad applications in oncology, developmental biology, and regenerative medicine.
Siqi Li, Kun Wang, Xin Wang, Zheng Hu
wiley   +1 more source

Developmental plasticity of hermaphrodite sperm production across environments in Caenorhabditis elegans. [PDF]

PLoS One
Gimond C, Poullet N, Vielle A, Demoinet E, Braendle C.   +4 more
europepmc   +1 more source

Diverse reference genomes detect variants in the US winter wheat

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract The first hexaploid bread wheat reference genome from Chinese Spring was released in 2018 by the International Wheat Genome Sequencing Consortium and is considered as the industry standard reference. To explore the effects of different reference genomes on variant discovery, 29 hexaploid bread wheat (Triticum aestivum L.) cultivars from the ...
Kyle Parker, Zhen Wang, Yahya Rauf, Liangliang Gao, Jesse Poland, Jackie Rudd, Amir Ibrahim, Shuyu Liu   +7 more
wiley   +1 more source

Identifying regulators of associative learning using a protein-labelling approach in <i>Caenorhabditis elegans</i>. [PDF]

Elife
Rahmani A, McMillen A, Allen E, Ansaar R, Green R, Johnson ME, Poljak A, Chew YL.   +7 more
europepmc   +1 more source

Multiple Wnts and Frizzled Receptors Regulate Anteriorly Directed Cell and Growth Cone Migrations in Caenorhabditis elegans [PDF]

, 2006
Chun‐Liang Pan, James Endres Howell, Scott G. Clark, Massimo A. Hilliard, Shaun Cordes, Cornelia I. Bargmann, Gian Garriga   +6 more
openalex   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source