Results 191 to 200 of about 193,403 (293)

AI‐Driven Identification of Exceptionally Efficacious Polypharmacological Compounds That Extend the Lifespan of Caenorhabditis elegans

Aging Cell, EarlyView.
A retrospective analysis of the most effective known geroprotectors shows that they act by polypharmacological mechanisms. Using graph neural networks, we predict polypharmacological geroprotectors, validate their polypharmacological mechanisms experimentally, and show them to be exceptionally effective.
Konstantin Avchaciov, Khalyd J. Clay, Kirill A. Denisov, Olga Burmistrova, Michael Petrascheck, Peter O. Fedichev   +5 more
wiley   +1 more source

A second trans-spliced RNA leader sequence in the nematode Caenorhabditis elegans.

, 1989
Xuming Huang, David Hirsh
openalex   +1 more source

Aged Gut Microbiota Contributes to Cognitive Impairment and Hippocampal Synapse Loss in Mice

Aging Cell, EarlyView.
Li et al. revealed that aged gut microbiota induces cognitive decline and microglia‐mediated synapse loss. Fecal Bifidobacterium pseudolongum abundance was reduced in patients with cognitive impairment and microbiota transplantation from patients with fewer B.p abundance yielded worse cognitive behavior in mice.
Mingxiao Li, Yiyang Bao, Jiaoqi Ren, Wenjing Wei, Xuefei Yu, Xiaofang He, Mutalifu gulisima, Lili Sheng, Ningning Zheng, Jianbo Wan, Houguang Zhou, Ling Zhao, Houkai Li   +12 more
wiley   +1 more source

ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds

Aging Cell, EarlyView.
ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan, Hongxia Cai, Fang Ye, Wentao Xu, Zhihang Huang, Jingyuan Zhu, Yiwen Gong, Yutong Li, Anastasia Ngozi Ezemaduka, Shan Gao, Shunqi Liu, Guojun Li, Hao Li, Jing Yang, Junyu Ning, Bo Xian   +15 more
wiley   +1 more source

Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications

Brain Pathology, EarlyView.
Elevated angiogenin levels in skeletal muscle are linked to slower disease progression, enhanced regeneration, and vascularization through satellite‐endothelial interaction during myogenesis in ALS. Angiogenin and its tiRNAs may serve as prognostic markers and therapeutic targets for ALS.
Paola Fabbrizio, Sharada Baindoor, Cassandra Margotta, Junyi Su, Elena P. Morrissey, Ina Woods, Marion C. Hogg, Sara Vianello, Morten T. Venø, Jørgen Kjems, Gianni Sorarù, Caterina Bendotti, Jochen H. M. Prehn, Giovanni Nardo   +13 more
wiley   +1 more source

Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes,Ascaris suumandCaenorhabditis elegans [PDF]

, 1990
Ronald Okimoto, Jane L. Macfarlane, David R. Wolstenholme   +2 more
openalex   +1 more source

Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans. [PDF]

, 1991
Michael A. Lochrie, Jane Mendel, Paul W. Sternberg, Melvin I. Simon   +3 more
openalex   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, EarlyView.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans [PDF]

, 1990
Martin Chalfie, Eve Wolinsky
openalex   +1 more source

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source