Microbial genetic screen identifies bacterial genes that compromise <i>Caenorhabditis elegans</i> reproductive fitness. [PDF]
Yang Z +9 more
europepmc +1 more source
Cryo‐EM structure of ALC1 in an open conformation bound to a PARylated nucleosome
Reanalysis of a publicly available cryo‐EM dataset identifies a new conformation of the oncogenic chromatin remodeler ALC1/CHD1L bound to a PARylated nucleosome. This new structure reveals the position of the macro domain in the complex, and may help to understand the large conformational change leading to the activation of ALC1.Nucleosomes are the ...
Hannah R. Bridges +3 more
wiley +1 more source
SIN-3 coregulator maintains adaptive capacity to different diets in Caenorhabditis elegans through vitamin B12. [PDF]
Palladino F, Bedet C.
europepmc +1 more source
Predator–Microbe Dynamics Inform Strategies for Robust Synthetic Community Assembly
This Review introduces ecological principles of predator–prey interactions as a new dimension in SynCom design. By linking microbial defence traits, encounter dynamics, and adaptive buffering, it outlines a framework for constructing predator‐resistant synthetic communities with enhanced resilience, stability, and functional performance under natural ...
Eleonora Egidi, Uffe N. Nielsen
wiley +1 more source
Systematic optimization of <i>Caenorhabditis elegans</i> cryopreservation. [PDF]
Agrawal S, Babu KR.
europepmc +1 more source
Genomic Map of Escherichia coli and Single Nucleotide Polymorphism Markers in Colorectal Cancer
This study identified colorectal cancer‐associated SNPs in Escherichia coli using PacBio full‐genome sequencing, establishing a highly accurate SNP‐based model for non‐invasive colorectal cancer risk prediction. ABSTRACT Gut microbial single nucleotide polymorphisms (SNPs) offer stable, specific genetic markers for disease diagnosis.
Yang Xi +10 more
wiley +1 more source
Integrating MACSPI and SILAC for Neuron Type-specific Proteomics in Caenorhabditis elegans. [PDF]
Ran Q, Huang S, Li XD, Zheng C.
europepmc +1 more source
Loss of SMARCAD1 Mitigates Tauopathy
Using genetics approaches in a C. elegans transgenic model of tauopathy, we uncover a role for the homolog of human SMARCAD1, a regulator of chromatin dynamics. ABSTRACT Tauopathies are neurodegenerative diseases characterized by the accumulation of misfolded tau protein and include Alzheimer's disease (AD) and related dementia disorders.
Vaishnavi S. Jadhav +7 more
wiley +1 more source
Lipid Analysis in Live <i>Caenorhabditis elegans</i> Using Solution-State NMR Spectroscopy. [PDF]
Guastaferri FV +5 more
europepmc +1 more source

