Results 31 to 40 of about 288,938 (268)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

O COLAPSO DO CICLO ECONÔMICO BRASILEIRO NO PERÍODO MILITAR/The Collapse of the Brazilian Economic Cycle in the Military Period

Informe Gepec, 2023
Este trabalho tem por objetivo fornecer uma leitura econômica do final do governo militar brasileiro segundo a teoria austríaca dos ciclos econômicos. O auge desse período, chamado de “milagre” econômico, deu início a um ciclo que culminou na crise dos ...
José Henrique Bassi Souza Sperancini, Paulo Pio Dantas   +1 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Sea ice and millennial-scale climate variability in the Nordic seas 90 kyr ago to present

Nature Communications, 2016
The response of Arctic sea-ice to rapid climatic change in the past remains uncertain. Here, the authors use biomarkers and microfossils to reconstruct Arctic sea-ice changes over the past 90,000 years, and demonstrate millennial-scale variability.
Ulrike Hoff, Tine L. Rasmussen, Ruediger Stein, Mohamed M. Ezat, Kirsten Fahl   +4 more
doaj   +1 more source

CHARACTERISTIC OF SPAWNERS FOR AMUR STURGEON ACIPENSER SCHRENCKII FROM WARM-WATER CAGE FARM IN THE PROCESS OF LONG-TERM EXPLOITATION

Известия ТИНРО, 2018
Cultivation, biological and production parameters of domesticated spawners of amur sturgeon in the age from 8 to 24 years are described for the warm-water cage farm conditions.
E. I. Rachek, D. Y. Amvrosov
doaj   +1 more source

The extreme yet transient nature of glacial erosion

Nature Communications, 2022
Glacial erosion processes over geological timescales are poorly understood. Here the authors apply an observationally constrained model to reconstruct the evolving thermodynamics and transient erosional signature of the Eurasian Ice Sheet over the last ...
H. Patton, A. Hubbard, J. Heyman, N. Alexandropoulou, A. P. E. Lasabuda, A. P. Stroeven, A. M. Hall, M. Winsborrow, D. E. Sugden, J. Kleman, K. Andreassen   +10 more
doaj   +1 more source

Weighted cages

Discrete Applied Mathematics
Cages ($r$-regular graphs of girth $g$ and minimum order) and their variants have been studied for over seventy years. Here we propose a new variant, "weighted cages". We characterize their existence; for cases $g=3,4$ we determine their order; we give Moore-like bounds and present some computational results.
Gabriela Araujo-Pardo, Claudia De la Cruz, Martín Matamala, Miguel A. Pizaña   +3 more
openaire   +2 more sources

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source