Results 1 to 10 of about 557 (132)
Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors [PDF]
Nature CommunicationsObesity is a major and increasingly prevalent chronic metabolic disease with numerous comorbidities. While recent incretin-based therapies have provided pharmaceutical inroads into treatment of obesity, there remains an ongoing need for additional ...
Giuseppe Deganutti +2 more
exaly +7 more sources
Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3Research in context [PDF]
EBioMedicineSummary: Background: Amylin (AmyR) and calcitonin (CTR) receptor co-agonists are currently in Phase II/III clinical trials for obesity treatment. Amylin binds to a heterodimeric receptor composed of CTR and the receptor activity modifying proteins 1, 2 ...
Alexandra Oliveira Carvas +11 more
doaj +7 more sources
Efficacy and Safety of Cagrilintide Alone and in Combination with Semaglutide (Cagrisema) as Anti-Obesity Medications: A Systematic Review and Meta-Analysis [PDF]
Indian Journal of Endocrinology and MetabolismNo meta-analysis has analysed role of cagrilintide as weight-loss medication in obese individuals. Electronic databases were searched for RCTs involving obese individuals receiving cagrilintide or cagrilintide-2.4 mg with semaglutide-2.4 mg combination ...
Ameya S Joshi +2 more
exaly +6 more sources
Journal of Clinical QuestionIntroduction: Incretin-based therapies, including glucagon-like peptide-1 receptor agonists and amylin analogues, have emerged as promising treatments for obesity.
Yange Meng +4 more
doaj +2 more sources
Journal of Clinical QuestionIntroduction: Type 2 diabetes mellitus (T2DM) is commonly associated with obesity and increased cardiometabolic risk, highlighting the need for therapies that optimize both glycemic control and weight management.
Ting Jin +3 more
doaj +2 more sources
Amylin as a Future Obesity Treatment
Journal of Obesity & Metabolic Syndrome, 2021 Obesity is defined as abnormal or excessive fat accumulation that contributes to detrimental health impacts. One-third of the population suffers from obesity, and it is important to consider obesity as a chronic disease requiring chronic treatment ...
Babak Dehestani +2 more
doaj +1 more source
Journal of Obesity & Metabolic Syndrome, 2023 Obesity is a prevalent global health issue affecting approximately half of the world’s population. Extensive scientific research highlights the urgent need for effective obesity management to mitigate health risks and prevent complications.
Eonju Jeon, Ki Young Lee, Kyoung-Kon Kim
doaj +1 more source
Targeting Obesity in PCOS: A Review of Current Pharmacological Interventions and Future Directions [PDF]
Modern MedicineObesity is a common and significant comorbidity of Polycystic Ovary Syndrome (PCOS), contributing to a range of metabolic and reproductive complications.
Dharani BHASKARAN, Suba ANGAPPAN
doaj +1 more source
AMYLIN AND AMYLIN ANALOGS – FUTURE THERAPEUTIC STRATEGIES FOR THE TREATMENT OF TYPE 2 DIABETES AND OBESITY [PDF]
Journal of IMABAmylin is a peptide hormone co-synthesized with insulin in pancreatic beta cells at a ratio of 1:100. Notably, amylin has a pronounced tendency to form toxic amyloid fibrils, a characteristic relevant to its pathological role.
Nikolinka Koleva +2 more
doaj +1 more source
Tirzepatide vs. Cagrilintide/Semaglutide: A New Frontier in Pharmacological Management of Obesity
Journal of Education, Health and SportObesity is a chronic, multifactorial disease with escalating global prevalence, associated with profound metabolic, cardiovascular, and oncological comorbidities.
Marcelina Rybińska +3 more
doaj +1 more source