Results 1 to 10 of about 8,623 (115)

Role and Cytotoxicity of Amylin and Protection of Pancreatic Islet β-Cells from Amylin Cytotoxicity

Cells, 2018
Amylin, (or islet amyloid polypeptide; IAPP), a 37-amino acid peptide hormone, is released in response to nutrients, including glucose, lipids or amino acids. Amylin is co-stored and co-secreted with insulin by pancreatic islet β-cells.
Yoshimitsu Kiriyama, Hiromi Nochi
exaly   +3 more sources

Amylin – Its role in the homeostatic and hedonic control of eating and recent developments of amylin analogs to treat obesity

Molecular Metabolism, 2018
Background: Amylin is a pancreatic β-cell hormone that produces effects in several different organ systems. One of its best-characterized effects is the reduction in eating and body weight seen in preclinical and clinical studies.
Christina Neuner Boyle, Thomas A. Lutz, Christelle Le Foll   +2 more
exaly   +3 more sources

Not only gut feelings: pancreatic hormone, amylin, controls emotionality and sociability, in a sex divergent manner [PDF]

Translational Psychiatry
Amylin, a pancreatic peptide hormone, has gained attention for its role in appetite regulation. Its analogues are approved for use in diabetic patients, and it is now under investigation as a potential anti-obesity therapeutic.
Suyeun Byun, Morgan R. Sotzen, Mya A. Knappenberger, Doris I. Olekanma, Madison Bento, Karolina P. Skibicka   +5 more
doaj   +2 more sources

Intrathecal amylin reverses morphine tolerance through site-specific DNA methylation of Pdyn and Bdnf promoters in rats [PDF]

Scientific Reports
Chronic use of opioids such as morphine can lead to tolerance, opioid-induced hyperalgesia, and addiction. Amylin has demonstrated analgesic properties and the ability to reverse morphine properties when injected intrathecally in rats. Our previous study
Sara Edalat Behbahani, Hajar Jaberie, Mohsen Tatar, Fatemeh Zal, Ali Akbar Owji, Zahra Khoshdel   +5 more
doaj   +2 more sources

Amylin Revisited: A 5-Year Perspective on Its Emerging Role in the Treatment of Diabesity [PDF]

Journal of Obesity & Metabolic Syndrome
Amylin is a pancreatic peptide hormone that regulates blood glucose levels and appetite. This review outlines the physiological role of amylin and highlights recent clinical studies exploring its therapeutic potential in diabetes and obesity.
Chae Won Chung, Jaetaek Kim
doaj   +2 more sources

The association of circulating amylin with β‐amyloid in familial Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction This study assessed the hypothesis that circulating human amylin (amyloid‐forming) cross‐seeds with amyloid beta (Aβ) in early Alzheimer's disease (AD).
Han Ly, Nirmal Verma, Savita Sharma, Deepak Kotiya, Sanda Despa, Erin L. Abner, Peter T. Nelson, Gregory A. Jicha, Donna M. Wilcock, Larry B. Goldstein, Rita Guerreiro, José Brás, Angela J. Hanson, Suzanne Craft, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, AESG, Florin Despa   +21 more
doaj   +1 more source

Hypophagia induced by salmon calcitonin, but not by amylin, is partially driven by malaise and is mediated by CGRP neurons

Molecular Metabolism, 2022
Objective: The behavioral mechanisms and the neuronal pathways mediated by amylin and its long-acting analog sCT (salmon calcitonin) are not fully understood and it is unclear to what extent sCT and amylin engage overlapping or distinct neuronal ...
Lavinia Boccia, Tito Borner, Misgana Y. Ghidewon, Patricia Kulka, Chiara Piffaretti, Sarah A. Doebley, Bart C. De Jonghe, Harvey J. Grill, Thomas A. Lutz, Christelle Le Foll   +9 more
doaj   +1 more source

Oral Amylin Treatment Reduces the Pathological Cascade of Alzheimer’s Disease in a Mouse Model

American Journal of Alzheimer's Disease and Other Dementias, 2021
Intraperitoneal injection of amylin or its analog reduces Alzheimer’s disease (AD) pathology in the brains. However, self-injecting amylin analogs is difficult for patients due to cognitive deficits.
Hana Na PhD, Hua Tian PhD, Zhengrong Zhang PhD, Qiang Li PhD, Jack B. Yang BS, Liam Mcparland BS, Qini Gan PhD, Wei Qiao Qiu MD, PhD   +7 more
doaj   +1 more source

Inter-species cross-seeding: stability and assembly of rat-human amylin aggregates. [PDF]

PLoS ONE, 2014
Diseases such as type 2 diabetes, Alzheimer's and Parkinson's share as common feature the accumulation of mis-folded disease-specific protein aggregates into fibrillar structures, or plaques.
Workalemahu M Berhanu, Ulrich H E Hansmann   +1 more
doaj   +1 more source

The assessment value of pathological condition of serum adiponectin and amylin in primary osteoporosis and its correlation analysis with bone metabolism indexes [PDF]

Journal of Medical Biochemistry, 2023
Background: This paper explores the assessment value of pathological condition of serum adiponectin (APN) and amylin in primary osteoporosis (POP) and their correlation with bone metabolism indexes.
Wang Xiao Jie, Bai Xue, Miu Ying, Chen Pan, Yan Pi Jun, Jiang Chun Xia   +5 more
doaj   +1 more source