Results 31 to 40 of about 11,774 (158)

Associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy Chinese. [PDF]

PLoS ONE, 2011
BACKGROUND: Cellular and animal studies implicate multiple roles of amylin in regulating insulin action, glucose and lipid metabolisms. However, the role of amylin in obesity related metabolic disorders has not been thoroughly investigated in humans ...
Xinwei Hou, Liang Sun, Zongmeng Li, Haiwei Mou, Zhijie Yu, Huaixing Li, Peizhen Jiang, Danxia Yu, Hongyu Wu, Xingwang Ye, Xu Lin, Yingying Le   +11 more
doaj   +1 more source

Fibril formation and toxicity of the non-amyloidogenic rat amylin peptide

, 2013
Full-length native rat amylin 1-37 has previously been widely shown to be unable to form fibrils and to lack the toxicity of the human amylin form leading to its use as a non-amyloidogenic control peptide.
Harris, J.R., Milton, N.G.N.
core   +1 more source

Biotinyl analogues of amylin as biologically active probes for amylin/CGRP receptor recognition [PDF]

, 1992
Biotinyl analogues of rat amylin were synthesised with sulfosuccinimidyl 2-(biotinamido)ethyl-1,3-dithiopropionate(NHS-SS-Biotin). Biotinylated amylin peptides were purified by HPLC, quantitated, and the presence of the biotin group at Lys-1 confirmed by
Foot, Elizabeth A., Day, Anthony J., Willis, Antony C., Leighton, Brendan, Day, Anthony J.; id_orcid, Brendan Leighton, Antony C. Willis, Elizabeth A. Foot, Chantry, Andrew, Andrew Chantry, Anthony J. Day   +10 more
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Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress

, 2015
Recent evidence showed that amylin deposition is not only found in the pancreas in type 2 diabetes mellitus (T2DM) patients, but also in other peripheral organs, such as kidneys, heart and brain.
Yu, Xiao-Lin, Li, Ya-Nan, Zhou, Wei-Wei, Xu, Peng-Xin, Wang, Shao-Wei, Wang, Yu-Jiong, Zhang, He, Liu, Rui-Tian, Su, Ya-Jing, Zhang, Zi-Ping   +9 more
core   +1 more source

Amylin exacerbates tau pathology in the visual cortex of diabetic mice by impairing lysosomal activity

Genes and Diseases
The aggregation of the peptide hormone amylin in the pancreas is a pathological hallmark of type-2 diabetes. Additionally, amylin can form aggregates in the brain, promoting β-amyloid deposition and tau phosphorylation in Alzheimer's disease.
Daniel Moreira-Silva, Melike Yuksel, Moorthi Ponnusamy, Mitchell T. Hansen, Joseph D. McMillan, Sneha Geethakrishnan, Shuai Wang, Lisa A. Collier, Gopal Thinakaran   +8 more
doaj   +1 more source

Amylin as a Future Obesity Treatment

Journal of Obesity & Metabolic Syndrome, 2021
Obesity is defined as abnormal or excessive fat accumulation that contributes to detrimental health impacts. One-third of the population suffers from obesity, and it is important to consider obesity as a chronic disease requiring chronic treatment ...
Babak Dehestani, Nicholas RS Stratford, Carel W le Roux   +2 more
doaj   +1 more source

Systemic and central amylin, amylin receptor signaling, and their physiological and pathophysiological roles in metabolism

, 2020
This article in the Neural and Endocrine Section of Comprehensive Physiology discusses the physiology and pathophysiology of the pancreatic hormone amylin.
Christelle Le Foll, Le Foll, Christelle; https://orcid.org/, Thomas A. Lutz, Lutz, Thomas A; https://orcid.org/   +3 more
core   +1 more source

Amylin inhibits gastric cancer progression by targeting CCN1 and affecting the PI3K/AKT signalling pathway

Annals of Medicine
Background: After glucagon and insulin, amylin is the third most significant and active islet hormone. Amylin and insulin act synergistically to suppress postprandial blood glucose levels.
Li Liu, Wenxuan Liu, Wenhong Deng
doaj   +1 more source

Amylin: Localization, Effects on Cerebral Arteries and on Local Cerebral Blood Flow in the Cat

The Scientific World Journal, 2001
Amylin and adrenomedullin are two peptides structurally related to calcitonin gene-related peptide (CGRP). We studied the occurrence of amylin in trigeminal ganglia and cerebral blood vessels of the cat with immunocytochemistry and evaluated the role of ...
Lars Edvinsson, Peter J. Goadsby, Rolf Uddman   +2 more
doaj   +1 more source

Functional study of amylin and regulation of amylin receptor

, 2010
Amylin, a 37 amino acid peptide secreted from pancreatic beta cells upon stimulation by meal/glucose, belongs to the family of the calcitonin or calcitonin gene-related peptide (CGRP) and shares up to 50% homology with CGRP, which is a well-documented ...
Huang, Xiaofang
core   +1 more source