Inter-species cross-seeding: stability and assembly of rat-human amylin aggregates. [PDF]
PLoS ONE, 2014 Diseases such as type 2 diabetes, Alzheimer's and Parkinson's share as common feature the accumulation of mis-folded disease-specific protein aggregates into fibrillar structures, or plaques.
Workalemahu M Berhanu +1 more
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The assessment value of pathological condition of serum adiponectin and amylin in primary osteoporosis and its correlation analysis with bone metabolism indexes [PDF]
Journal of Medical Biochemistry, 2023 Background: This paper explores the assessment value of pathological condition of serum adiponectin (APN) and amylin in primary osteoporosis (POP) and their correlation with bone metabolism indexes.
Wang Xiao Jie +5 more
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Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells
Pharmaceutics, 2021 In recent decades, type 2 diabetes complications have been correlated with amylin aggregation, copper homeostasis and metformin side effects. However, each factor was analyzed separately, and only in some rare cases copper/amylin or copper/metformin ...
Terenzio Congiu +10 more
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MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2. [PDF]
PLoS ONE, 2011 BackgroundAmylin is the most abundant component of islet amyloid implicated in the development of type 2 diabetes. Plasma amylin levels are elevated in individuals with obesity and insulin resistance.
Kun Cai +8 more
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Monoconjugation of Human Amylin with Methylpolyethyleneglycol. [PDF]
PLoS ONE, 2015 Amylin is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. The therapeutic restoration of postprandial and basal amylin levels is highly desirable in diabetes mellitus.
Tháyna Sisnande +7 more
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Differential effect of amylin on endothelial-dependent vasodilation in mesenteric arteries from control and insulin resistant rats. [PDF]
PLoS ONE, 2015 Insulin resistance (IR) is frequently associated with endothelial dysfunction and has been proposed to play a major role in cardiovascular disease (CVD). On the other hand, amylin has long been related to IR.
Mariam El Assar +6 more
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The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats
Molecular Metabolism, 2016 Objective: Adult neurogenesis in the subgranular zone and subventricular zone is generally accepted, but its existence in other brain areas is still controversial.
Claudia G. Liberini +3 more
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Amylin receptor: a common pathophysiological target in Alzheimer’s Disease and Diabetes Mellitus
Frontiers in Aging Neuroscience, 2013 Amylin (islet amyloid polypeptide) and amyloid beta protein (Abeta), which are deposited within pancreatic islets of diabetics and brains of Alzheimer’s patients respectively, share many biophysical and physiological properties.
Wen eFu, Aarti ePatel, Jack H. Jhamandas
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Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes. [PDF]
PLoS ONE, 2016 In type 1 diabetes (T1D), β-cell loss is silent during disease progression. Methylation-sensitive quantitative real-time PCR (qPCR) of β-cell-derived DNA in the blood can serve as a biomarker of β-cell death in T1D.
John A Olsen +4 more
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PLoS ONE, 2019 The development of inhibitors of islet amyloid formation is important as pancreatic amyloid deposition contributes to type-2 diabetes and islet transplant failure.
Rehana Akter +4 more
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