Results 11 to 20 of about 8,359 (180)

Amylin Receptor 1 Mutagenesis Revealed a Potential Role of Calcitonin Serine 29 in Receptor Interaction [PDF]

Biomedicines
Background: The amylin receptor is a receptor for the peptide hormone amylin, and its activation is known to reduce body weight. The amylin receptor functions as a heterodimer complex that consists of the calcitonin receptor for peptide hormone ...
Hyeseon Song, Jaehyeok Jang, Minjae Park, Junsu Yun, Jeongwoo Jin, Sangmin Lee   +5 more
doaj   +2 more sources

Hypophagia induced by salmon calcitonin, but not by amylin, is partially driven by malaise and is mediated by CGRP neurons

Molecular Metabolism, 2022
Objective: The behavioral mechanisms and the neuronal pathways mediated by amylin and its long-acting analog sCT (salmon calcitonin) are not fully understood and it is unclear to what extent sCT and amylin engage overlapping or distinct neuronal ...
Lavinia Boccia, Tito Borner, Misgana Y. Ghidewon, Patricia Kulka, Chiara Piffaretti, Sarah A. Doebley, Bart C. De Jonghe, Harvey J. Grill, Thomas A. Lutz, Christelle Le Foll   +9 more
doaj   +1 more source

The association of circulating amylin with β‐amyloid in familial Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction This study assessed the hypothesis that circulating human amylin (amyloid‐forming) cross‐seeds with amyloid beta (Aβ) in early Alzheimer's disease (AD).
Han Ly, Nirmal Verma, Savita Sharma, Deepak Kotiya, Sanda Despa, Erin L. Abner, Peter T. Nelson, Gregory A. Jicha, Donna M. Wilcock, Larry B. Goldstein, Rita Guerreiro, José Brás, Angela J. Hanson, Suzanne Craft, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, AESG, Florin Despa   +21 more
doaj   +1 more source

Oral Amylin Treatment Reduces the Pathological Cascade of Alzheimer’s Disease in a Mouse Model

American Journal of Alzheimer's Disease and Other Dementias, 2021
Intraperitoneal injection of amylin or its analog reduces Alzheimer’s disease (AD) pathology in the brains. However, self-injecting amylin analogs is difficult for patients due to cognitive deficits.
Hana Na PhD, Hua Tian PhD, Zhengrong Zhang PhD, Qiang Li PhD, Jack B. Yang BS, Liam Mcparland BS, Qini Gan PhD, Wei Qiao Qiu MD, PhD   +7 more
doaj   +1 more source

Inter-species cross-seeding: stability and assembly of rat-human amylin aggregates. [PDF]

PLoS ONE, 2014
Diseases such as type 2 diabetes, Alzheimer's and Parkinson's share as common feature the accumulation of mis-folded disease-specific protein aggregates into fibrillar structures, or plaques.
Workalemahu M Berhanu, Ulrich H E Hansmann   +1 more
doaj   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Petrelintide for Weight Management: Two Randomized, Controlled Phase 1 Trials. [PDF]

Diabetes Obes Metab
ABSTRACT Aims Petrelintide is a long‐acting amylin analogue in development for weight management. The safety, tolerability, pharmacokinetics, and pharmacodynamics of petrelintide were evaluated in single ascending dose (SAD) and multiple ascending dose (MAD) trials. Materials and Methods Both trials were randomized, placebo‐controlled, and double‐blind.
Brændholt Olsen M, Griffin J, Hövelmann U, Macura S, Fredsted Hagen B, Hesse D, Heise T.   +6 more
europepmc   +2 more sources

The assessment value of pathological condition of serum adiponectin and amylin in primary osteoporosis and its correlation analysis with bone metabolism indexes [PDF]

Journal of Medical Biochemistry, 2023
Background: This paper explores the assessment value of pathological condition of serum adiponectin (APN) and amylin in primary osteoporosis (POP) and their correlation with bone metabolism indexes.
Wang Xiao Jie, Bai Xue, Miu Ying, Chen Pan, Yan Pi Jun, Jiang Chun Xia   +5 more
doaj   +1 more source

Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells

Pharmaceutics, 2021
In recent decades, type 2 diabetes complications have been correlated with amylin aggregation, copper homeostasis and metformin side effects. However, each factor was analyzed separately, and only in some rare cases copper/amylin or copper/metformin ...
Terenzio Congiu, Mawadda Alghrably, Abdul-Hamid Emwas, Lukasz Jaremko, Joanna I. Lachowicz, Marco Piludu, Monica Piras, Gavino Faa, Giuseppina Pichiri, Mariusz Jaremko, Pierpaolo Coni   +10 more
doaj   +1 more source

MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2. [PDF]

PLoS ONE, 2011
BackgroundAmylin is the most abundant component of islet amyloid implicated in the development of type 2 diabetes. Plasma amylin levels are elevated in individuals with obesity and insulin resistance.
Kun Cai, Dongfei Qi, Xinwei Hou, Oumei Wang, Juan Chen, Bo Deng, Lihua Qian, Xiaolong Liu, Yingying Le   +8 more
doaj   +1 more source

Monoconjugation of Human Amylin with Methylpolyethyleneglycol. [PDF]

PLoS ONE, 2015
Amylin is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. The therapeutic restoration of postprandial and basal amylin levels is highly desirable in diabetes mellitus.
Tháyna Sisnande, Luiz Henrique Guerreiro, Raquel R Braga, Luana Jotha-Mattos, Luiza C S Erthal, Priscilla Tinoco, Bruno M Ferreira, Luís Maurício T R Lima   +7 more
doaj   +1 more source