Results 11 to 20 of about 11,774 (158)
Amylin induces hypoglycemia in mice [PDF]
Anais da Academia Brasileira de Ciências, 2013 Amylin is a 37-aminoacid pancreatic protein that exerts control over several metabolic events such as glycemia and lacticemia. Amylin has long been shown to induce increases in arterial plasma glucose.
Luiz H. Guerreiro +4 more
doaj +2 more sources
Monoconjugation of Human Amylin with Methylpolyethyleneglycol. [PDF]
PLoS ONE, 2015 Amylin is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. The therapeutic restoration of postprandial and basal amylin levels is highly desirable in diabetes mellitus.
Tháyna Sisnande +7 more
doaj +2 more sources
The Scientific World Journal, 2003 Amylin (islet amyloid polypeptide) is a peptide synthesized principally in the b-cells of the pancreatic islets together with insulin and has actions as a hormone, growth factor, and modifier of behavior.
Peter J. Wookey +3 more
doaj +2 more sources
Type 1 diabetes in the era of obesity: Pathophysiology and therapeutic implications. [PDF]
J Diabetes InvestigABSTRACT Type 1 diabetes is defined by immune‐mediated beta‐cell failure and dependence on exogenous insulin. That definition is correct, but it may not fully describe many people seen in current clinical practice. Overweight and obesity are now common in type 1 diabetes, leading to variable combinations of high insulin requirement, hypertension ...
Bloomgarden Z.
europepmc +2 more sources
Amyloid-Forming Amylin Secreted by the Pancreas Promotes Hypoxia-Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis. [PDF]
Compr PhysiolHuman amylin is secreted from the pancreas of HIP rats and is amyloidogenic, forming aggregates systemically. In comparison with age‐matched control (WT), hyperglycemic (UCD) and amylin knockout rats (AKO), HIP rats showed increased hypoxia‐inducible factors (HIF‐1/2) in heart and liver, alongside alterations in mitochondrial electron transfer system ...
Knapton AE +9 more
europepmc +2 more sources
Metabolic effects of amylin in lactating goats
, 1999 The objective of this study was to investigate the role of amylin (a pancreatic hormone) in regulating metabolism in support of lactation. Rat amylin was infused (320 pmol·kg LW-1·h-1) for 6 h via an external pudic (mammary) artery into six lactating ...
Lee, J. +5 more
core +10 more sources
Effect of GLP-1 receptor agonist on nutrient intake: A narrative review. [PDF]
Nutr Clin PractAbstract Humans have a primitive defense mechanism called metabolic adaptation that slows voluntary weight loss. It works by downregulating hormones that reduce food intake and by lowering the metabolic rate. Second‐generation GLP‐1 receptor agonists, such as semaglutide or tirzepatide, promote weight loss by targeting this hormonal system to control ...
Fujioka K.
europepmc +2 more sources
Peptide Marriages: Modular Assembly of Multi-Agonist Therapeutics. [PDF]
ChemistryA modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kostadinova KA +11 more
europepmc +2 more sources
Creating the amylin story [PDF]
, 2022 This paper is based on a presentation given at the Annual Meeting of the Society for the Study of Ingestive Behavior in July 2021 and provides a personal view on some of the milestones in the discovery of amylin as a constituent of pancreatic islet ...
Lutz, Thomas A; https://orcid.org/
core +1 more source
Undercover Toxic Ménage à Trois of Amylin, Copper (II) and Metformin in Human Embryonic Kidney Cells
Pharmaceutics, 2021 In recent decades, type 2 diabetes complications have been correlated with amylin aggregation, copper homeostasis and metformin side effects. However, each factor was analyzed separately, and only in some rare cases copper/amylin or copper/metformin ...
Terenzio Congiu +10 more
doaj +1 more source