Differential effect of amylin on endothelial-dependent vasodilation in mesenteric arteries from control and insulin resistant rats. [PDF]
PLoS ONE, 2015 Insulin resistance (IR) is frequently associated with endothelial dysfunction and has been proposed to play a major role in cardiovascular disease (CVD). On the other hand, amylin has long been related to IR.
Mariam El Assar +6 more
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The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats
Molecular Metabolism, 2016 Objective: Adult neurogenesis in the subgranular zone and subventricular zone is generally accepted, but its existence in other brain areas is still controversial.
Claudia G. Liberini +3 more
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Amylin receptor: a common pathophysiological target in Alzheimer’s Disease and Diabetes Mellitus
Frontiers in Aging Neuroscience, 2013 Amylin (islet amyloid polypeptide) and amyloid beta protein (Abeta), which are deposited within pancreatic islets of diabetics and brains of Alzheimer’s patients respectively, share many biophysical and physiological properties.
Wen eFu, Aarti ePatel, Jack H. Jhamandas
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Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes. [PDF]
PLoS ONE, 2016 In type 1 diabetes (T1D), β-cell loss is silent during disease progression. Methylation-sensitive quantitative real-time PCR (qPCR) of β-cell-derived DNA in the blood can serve as a biomarker of β-cell death in T1D.
John A Olsen +4 more
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PLoS ONE, 2019 The development of inhibitors of islet amyloid formation is important as pancreatic amyloid deposition contributes to type-2 diabetes and islet transplant failure.
Rehana Akter +4 more
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Association between amylin and amyloid-β peptides in plasma in the context of apolipoprotein E4 allele. [PDF]
PLoS ONE, 2014 Amylin, a pancreatic peptide that readily crosses the blood brain barrier (BBB), and amyloid-beta peptide (Aβ), the main component of amyloid plaques and a major component of Alzheimer's disease (AD) pathology in the brain, share several features.
Wei Qiao Qiu +5 more
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Associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy Chinese. [PDF]
PLoS ONE, 2011 BACKGROUND: Cellular and animal studies implicate multiple roles of amylin in regulating insulin action, glucose and lipid metabolisms. However, the role of amylin in obesity related metabolic disorders has not been thoroughly investigated in humans ...
Xinwei Hou +11 more
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Amylin as a Future Obesity Treatment
Journal of Obesity & Metabolic Syndrome, 2021 Obesity is defined as abnormal or excessive fat accumulation that contributes to detrimental health impacts. One-third of the population suffers from obesity, and it is important to consider obesity as a chronic disease requiring chronic treatment ...
Babak Dehestani +2 more
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Quantitative, High-Throughput Assays for Proteolytic Degradation of Amylin
Methods and Protocols, 2020 Amylin is a pancreatic peptide hormone that regulates glucose homeostasis but also aggregates to form islet amyloid in type-2 diabetes. Given its role in both health and disease, there is renewed interest in proteolytic degradation of amylin by insulin ...
Caitlin N. Suire +2 more
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Genes and DiseasesThe aggregation of the peptide hormone amylin in the pancreas is a pathological hallmark of type-2 diabetes. Additionally, amylin can form aggregates in the brain, promoting β-amyloid deposition and tau phosphorylation in Alzheimer's disease.
Daniel Moreira-Silva +8 more
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