Results 21 to 30 of about 8,384 (181)

Associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy Chinese. [PDF]

PLoS ONE, 2011
BACKGROUND: Cellular and animal studies implicate multiple roles of amylin in regulating insulin action, glucose and lipid metabolisms. However, the role of amylin in obesity related metabolic disorders has not been thoroughly investigated in humans ...
Xinwei Hou, Liang Sun, Zongmeng Li, Haiwei Mou, Zhijie Yu, Huaixing Li, Peizhen Jiang, Danxia Yu, Hongyu Wu, Xingwang Ye, Xu Lin, Yingying Le   +11 more
doaj   +1 more source

Association between amylin and amyloid-β peptides in plasma in the context of apolipoprotein E4 allele. [PDF]

PLoS ONE, 2014
Amylin, a pancreatic peptide that readily crosses the blood brain barrier (BBB), and amyloid-beta peptide (Aβ), the main component of amyloid plaques and a major component of Alzheimer's disease (AD) pathology in the brain, share several features.
Wei Qiao Qiu, Max Wallack, Michael Dean, Elizabeth Liebson, Mkaya Mwamburi, Haihao Zhu   +5 more
doaj   +1 more source

Quantitative, High-Throughput Assays for Proteolytic Degradation of Amylin

Methods and Protocols, 2020
Amylin is a pancreatic peptide hormone that regulates glucose homeostasis but also aggregates to form islet amyloid in type-2 diabetes. Given its role in both health and disease, there is renewed interest in proteolytic degradation of amylin by insulin ...
Caitlin N. Suire, Monica K. Brizuela, Malcolm A. Leissring   +2 more
doaj   +1 more source

Amylin as a Future Obesity Treatment

Journal of Obesity & Metabolic Syndrome, 2021
Obesity is defined as abnormal or excessive fat accumulation that contributes to detrimental health impacts. One-third of the population suffers from obesity, and it is important to consider obesity as a chronic disease requiring chronic treatment ...
Babak Dehestani, Nicholas RS Stratford, Carel W le Roux   +2 more
doaj   +1 more source

Amylin exacerbates tau pathology in the visual cortex of diabetic mice by impairing lysosomal activity

Genes and Diseases
The aggregation of the peptide hormone amylin in the pancreas is a pathological hallmark of type-2 diabetes. Additionally, amylin can form aggregates in the brain, promoting β-amyloid deposition and tau phosphorylation in Alzheimer's disease.
Daniel Moreira-Silva, Melike Yuksel, Moorthi Ponnusamy, Mitchell T. Hansen, Joseph D. McMillan, Sneha Geethakrishnan, Shuai Wang, Lisa A. Collier, Gopal Thinakaran   +8 more
doaj   +1 more source

Amylin inhibits gastric cancer progression by targeting CCN1 and affecting the PI3K/AKT signalling pathway

Annals of Medicine
Background: After glucagon and insulin, amylin is the third most significant and active islet hormone. Amylin and insulin act synergistically to suppress postprandial blood glucose levels.
Li Liu, Wenxuan Liu, Wenhong Deng
doaj   +1 more source

Oxidant-modified amylin fibrils and aggregates alter the inflammatory profile of multiple myeloid cell types, but are non-toxic to islet β cells

Redox Biology, 2023
Diabetes mellitus currently affects ∼10% of the population worldwide, with Type 2 predominating, and this incidence is increasing steadily. Both Type 1 and 2 are complex diseases, involving β-cell death and chronic inflammation, but the pathways involved
Ramona Clemen, Eduardo Fuentes-Lemus, Sander Bekeschus, Michael J. Davies   +3 more
doaj   +1 more source

Amylin induces hypoglycemia in mice

Anais da Academia Brasileira de Ciências, 2013
Amylin is a 37-aminoacid pancreatic protein that exerts control over several metabolic events such as glycemia and lacticemia. Amylin has long been shown to induce increases in arterial plasma glucose.
Luiz H. Guerreiro, Daniel DA Silva, Mauro Sola-Penna, Daniella M. Mizurini, Luís M.T.R. Lima   +4 more
doaj   +1 more source

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Structural Analysis of Amylin and Amyloid β Peptide Signaling in Alzheimer’s Disease

Biomolecules
Amylin and amyloid β belong to the same protein family and activate the same receptors. Amyloid β levels are elevated in Alzheimer’s disease. Recent studies have demonstrated that amylin-based peptides can reduce the symptoms of Alzheimer’s disease in ...
Longsheng Xie, Christopher Lockhart, Steven R. Bowers, Dmitri K. Klimov, Mohsin Saleet Jafri   +4 more
doaj   +1 more source