Results 1 to 10 of about 6,150 (181)
Studies on alpha-synuclein and islet amyloid polypeptide interaction [PDF]
Frontiers in Molecular Biosciences, 2023 Introduction: Parkinson’s disease and type 2 diabetes have both elements of local amyloid depositions in their pathogenesis. In Parkinson’s disease, alpha-synuclein (aSyn) forms insoluble Lewy bodies and Lewy neurites in brain neurons, and in type 2 ...
Ye Wang +5 more
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Islet amyloid polypeptide does not suppress pancreatic cancer [PDF]
Molecular Metabolism, 2023 Objectives: Pancreatic cancer risk is elevated approximately two-fold in type 1 and type 2 diabetes. Islet amyloid polypeptide (IAPP) is an abundant beta-cell peptide hormone that declines with diabetes progression.
Austin J. Taylor +7 more
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O-glycosylated peptides curtail the aggregation and toxicity of human islet amyloid polypeptide [PDF]
Communications BiologyA key pathogenetic pathway of type 2 diabetes (T2D) is pancreatic beta cell failure, losing their capability of producing insulin and regulating blood glucose.
Qian Zhang +9 more
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The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells. [PDF]
PLoS ONE, 2015 Amyloid formation and mitochondrial dysfunction are characteristics of type 2 diabetes. The major peptide constituent of the amyloid deposits in type 2 diabetes is islet amyloid polypeptide (IAPP).
Hanjun Guan +5 more
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SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition
Molecular Metabolism, 2022 Objective: Sorting-related receptor with type A repeats (SORLA) is a neuronal sorting receptor that prevents accumulation of amyloid-beta peptides, the main constituent of senile plaques in Alzheimer disease. Recent transcriptomic studies show that SORLA
Alexis Z.L. Shih +6 more
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Communications Biology, 2021 Nguyen et al identified cytotoxic amyloid fibrils with oligomer-like characteristics, which were assembled from an islet amyloid polypeptide (IAPP) derivative containing an Asn-to-Gln substitution (N21Q). They presented evidence to show that these stable
Phuong Trang Nguyen +5 more
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Nature Communications, 2021 Islet amyloid polypeptide (IAPP) deposition is associated with islet cell loss in diabetes. Here the authors show that a small molecule autophagy enhancer reduces IAPP accumulation in vitro, and also improves glucose tolerance in hIAPP + mice fed high ...
Jinyoung Kim +14 more
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Frontiers in Microbiology, 2020 Diabetes is a major public health issue that has attained alarming levels worldwide. Pancreatic aggregates of human islet amyloid polypeptide (IAPP) represent a major histopathological hallmark of type 2 diabetes.
Ana F. Raimundo +11 more
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Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling. [PDF]
PLoS ONE, 2018 Amyloid formation in the pancreatic islets due to aggregation of human islet amyloid polypeptide (hIAPP) contributes to reduced β-cell mass and function in type 2 diabetes (T2D) and islet transplantation. Protein kinase B (PKB) signaling plays a key role
Yun Zhang +6 more
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Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets
Endocrine Connections, 2017 Islet amyloid and beta cell death in type 2 diabetes are heterogeneous events, where some islets are affected early in the disease process, whereas others remain visibly unaffected.
Sara Ullsten +5 more
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