SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition [PDF]
Molecular Metabolism, 2022 Objective: Sorting-related receptor with type A repeats (SORLA) is a neuronal sorting receptor that prevents accumulation of amyloid-beta peptides, the main constituent of senile plaques in Alzheimer disease. Recent transcriptomic studies show that SORLA
Alexis Z.L. Shih +6 more
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Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus [PDF]
Open MedicineType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and β-cell dysfunction. A hallmark of T2DM pathology is the accumulation of toxic amyloid polypeptides in and around pancreatic islet cells, leading to ...
Li GuangZhi, Zhang Dongmei
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RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes [PDF]
Molecular MetabolismObjective: Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 diabetes (T2D), but the mechanisms that underlie this process are incompletely ...
Noyonika Mukherjee +8 more
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O-glycosylated peptides curtail the aggregation and toxicity of human islet amyloid polypeptide [PDF]
Communications BiologyA key pathogenetic pathway of type 2 diabetes (T2D) is pancreatic beta cell failure, losing their capability of producing insulin and regulating blood glucose.
Qian Zhang +9 more
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The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells. [PDF]
PLoS ONE, 2015 Amyloid formation and mitochondrial dysfunction are characteristics of type 2 diabetes. The major peptide constituent of the amyloid deposits in type 2 diabetes is islet amyloid polypeptide (IAPP).
Hanjun Guan +5 more
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Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling. [PDF]
PLoS ONE, 2018 Amyloid formation in the pancreatic islets due to aggregation of human islet amyloid polypeptide (hIAPP) contributes to reduced β-cell mass and function in type 2 diabetes (T2D) and islet transplantation. Protein kinase B (PKB) signaling plays a key role
Yun Zhang +6 more
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Amyloid and Transplanted Islets [PDF]
New England Journal of Medicine, 2008 TO THE EDITOR: In their letter to the editor, Westermark and colleagues (Aug. 28 issue)1 report on their identification of amyloid in 43% of intrahepatically transplanted islets on postmortem examination of a recipient with type 1 diabetes. Amyloid is composed of amylin (islet amyloid polypeptide [IAPP]) that is cosecreted from the beta cell with ...
Michael R, Rickels +2 more
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High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus. [PDF]
PLoS ONE, 2014 Aims/hypothesisIslet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid ...
Johan F Paulsson +10 more
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Communications Biology, 2021 Nguyen et al identified cytotoxic amyloid fibrils with oligomer-like characteristics, which were assembled from an islet amyloid polypeptide (IAPP) derivative containing an Asn-to-Gln substitution (N21Q). They presented evidence to show that these stable
Phuong Trang Nguyen +5 more
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Molecular Metabolism, 2017 Objectives: β-cell dysfunction and apoptosis associated with islet inflammation play a key role in the pathogenesis of type 2 diabetes (T2D). Growing evidence suggests that islet amyloid, formed by aggregation of human islet amyloid polypeptide (hIAPP ...
Queenie Hui +6 more
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