Results 11 to 20 of about 10,923 (183)

Matrix Metalloproteinase-9 Reduces Islet Amyloid Formation by Degrading Islet Amyloid Polypeptide [PDF]

Journal of Biological Chemistry, 2013
Deposition of islet amyloid polypeptide (IAPP) as amyloid is a pathological hallmark of the islet in type 2 diabetes, which is toxic to β-cells. We previously showed that the enzyme neprilysin reduces islet amyloid deposition and thereby reduces β-cell apoptosis, by inhibiting fibril formation.
Kathryn, Aston-Mourney, Sakeneh, Zraika, Jayalakshmi, Udayasankar, Shoba L, Subramanian, Pattie S, Green, Steven E, Kahn, Rebecca L, Hull   +6 more
openaire   +2 more sources

Decreased islet amyloid polypeptide staining in the islets of insulinoma patients. [PDF]

Islets
Islet amyloid polypeptide (IAPP) is a factor that regulates food intake and is secreted from both pancreatic islets and insulinoma cells. Here, we aimed to evaluate IAPP immunohistochemically in islets or insulinoma cells in association with clinical characteristics.
Ishibashi C, Yoneda S, Fujita Y, Fujita S, Mitsushio K, Ozawa H, Baden MY, Nammo T, Kozawa J, Eguchi H, Shimomura I.   +10 more
europepmc   +3 more sources

An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

Nature Communications, 2021
Islet amyloid polypeptide (IAPP) deposition is associated with islet cell loss in diabetes. Here the authors show that a small molecule autophagy enhancer reduces IAPP accumulation in vitro, and also improves glucose tolerance in hIAPP + mice fed high ...
Jinyoung Kim, Kihyoun Park, Min Jung Kim, Hyejin Lim, Kook Hwan Kim, Sun-Woo Kim, Eun-Seo Lee, Hyongbum (Henry) Kim, Sung Joo Kim, Kyu Yeon Hur, Jae Hyeon Kim, Jin Hee Ahn, Kun-Ho Yoon, Ji-Won Kim, Myung-Shik Lee   +14 more
doaj   +1 more source

Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets

Endocrine Connections, 2017
Islet amyloid and beta cell death in type 2 diabetes are heterogeneous events, where some islets are affected early in the disease process, whereas others remain visibly unaffected.
Sara Ullsten, Sara Bohman, Marie E Oskarsson, K Peter R Nilsson, Gunilla T Westermark, Per-Ola Carlsson   +5 more
doaj   +1 more source

Amyloids in Site-Specific Autoimmune Reactions and Inflammatory Responses

Frontiers in Immunology, 2020
Amyloid deposition is a histological hallmark of common human disorders including Alzheimer's disease (AD) and type 2 diabetes. Although some reports highlight that amyloid fibrils might activate the innate immunity system via pattern recognition ...
Yan-Mei Huang, Yan-Mei Huang, Xue-Zhi Hong, Xue-Zhi Hong, Jian Shen, Jian Shen, Li-Jun Geng, Li-Jun Geng, Yan-Hong Pan, Yan-Hong Pan, Wei Ling, Wei Ling, Hai-Lu Zhao, Hai-Lu Zhao, Hai-Lu Zhao   +14 more
doaj   +1 more source

Degradation of islet amyloid polypeptide by neprilysin [PDF]

Diabetologia, 2012
A progressive loss of pancreatic beta cell function, a decrease in beta cell mass and accumulation of islet amyloid is characteristic of type 2 diabetes mellitus. The main constituent of islet amyloid is islet amyloid polypeptide (IAPP). In this study, we examined the ability of the peptidase neprilysin to cleave IAPP and prevent human IAPP-induced ...
H, Guan, K M, Chow, R, Shah, C J, Rhodes, L B, Hersh   +4 more
openaire   +2 more sources

4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity

Scientific Reports, 2021
Amyloid deposits in pancreatic islets, mainly formed by human islet amyloid polypeptide (hIAPP) aggregation, have been associated with loss of β-cell mass and function, and are a pathological hallmark of type 2 diabetes (T2D).
Sara de Pablo, Júlia Rodríguez-Comas, Daniela Díaz-Catalán, Gema Alcarraz-Vizán, Carlos Castaño, Juan Moreno-Vedia, Joel Montane, Marcelina Parrizas, Joan-Marc Servitja, Anna Novials   +9 more
doaj   +1 more source

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

Journal of Diabetes Research, 2016
The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose homeostasis but aggregates to form islet amyloid in type-2 diabetes. Islet amyloid formation contributes to β-cell dysfunction and death in the disease and to the failure of ...
Rehana Akter, Ping Cao, Harris Noor, Zachary Ridgway, Ling-Hsien Tu, Hui Wang, Amy G. Wong, Xiaoxue Zhang, Andisheh Abedini, Ann Marie Schmidt, Daniel P. Raleigh   +10 more
doaj   +1 more source

IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

Nature Communications, 2019
Type 2 diabetes is associated with islet amyloid deposits derived from islet amyloid polypeptide (IAPP) expressed by β-cells. Here the authors show that IAPP misfolded protein stress induces the hypoxia inducible factor 1 alpha injury repair pathway and ...
Chiara Montemurro, Hiroshi Nomoto, Lina Pei, Vishal S. Parekh, Kenny E. Vongbunyong, Suryakiran Vadrevu, Tatyana Gurlo, Alexandra E. Butler, Rohan Subramaniam, Eleni Ritou, Orian S. Shirihai, Leslie S. Satin, Peter C. Butler, Slavica Tudzarova   +13 more
doaj   +1 more source

Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus

Journal of Diabetes Research, 2016
Human islet amyloid polypeptide (hIAPP) is the major component of the amyloid deposits found in the pancreatic islets of patients with type 2 diabetes mellitus (T2DM).
Lucie Caillon, Anais R. F. Hoffmann, Alexandra Botz, Lucie Khemtemourian   +3 more
doaj   +1 more source