Results 1 to 10 of about 13,087 (187)
A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models [PDF]
Nature Communications, 2023 In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose.
Fabian Wirth +16 more
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Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation [PDF]
Biomolecules, 2021 Amyloid-formation by the islet amyloid polypeptide (IAPP), produced by the β-cells in the human pancreas, has been associated with the development of type II diabetes mellitus (T2DM).
Sanduni Wasana Jayaweera +7 more
doaj +2 more sources
Frontiers in Molecular Biosciences, 2022 The islet amyloid polypeptide (IAPP) is the main constituent of the amyloid fibrils found in the pancreas of type 2 diabetes patients. The aggregation of IAPP is known to cause cell death, where the cell membrane plays a dual role: being a catalyst of ...
Lucie Khemtemourian +8 more
doaj +1 more source
Interspecies Variation Affects IAPP Membrane Binding [PDF]
, 2023 The aggregation of islet amyloid polypeptide (IAPP) is associated with beta-cell dysfunction in type 2 diabetes (T2D) in humans. One possible mechanism of toxicity is the interaction of IAPP oligomers with lipid membranes to disrupt bilayer integrity and/
Henry, Sanders +7 more
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Frontiers in Molecular Biosciences, 2023 Insulin resistance is the major risk factor for Type 2 diabetes (T2D). In vulnerable individuals, insulin resistance induces a progressive loss of insulin secretion with islet pathology revealing a partial deficit of beta cells and islet amyloid derived ...
Tatyana Gurlo +8 more
doaj +1 more source
Studies on alpha-synuclein and islet amyloid polypeptide interaction
Frontiers in Molecular Biosciences, 2023 Introduction: Parkinson’s disease and type 2 diabetes have both elements of local amyloid depositions in their pathogenesis. In Parkinson’s disease, alpha-synuclein (aSyn) forms insoluble Lewy bodies and Lewy neurites in brain neurons, and in type 2 ...
Ye Wang +5 more
doaj +1 more source
Islet amyloid polypeptide does not suppress pancreatic cancer
Molecular Metabolism, 2023 Objectives: Pancreatic cancer risk is elevated approximately two-fold in type 1 and type 2 diabetes. Islet amyloid polypeptide (IAPP) is an abundant beta-cell peptide hormone that declines with diabetes progression.
Austin J. Taylor +7 more
doaj +1 more source
High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus. [PDF]
PLoS ONE, 2014 Aims/hypothesisIslet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid ...
Johan F Paulsson +10 more
doaj +1 more source
Interventionist Aid and the War in Ukraine [PDF]
The Review of International Affairs, 2023 Aid Policies In The First Year Of The War In Ukraine Constitute A Unique And Unprecedented Historical Case Destined To Leave An “Echo” In The International System Far Beyond Those Of The Individual Ukrainian Case And The Aid Sector Alone. Using A Realist
Igor Pellicciari
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 The cytotoxic self-aggregation of β-amyloid (Aβ) peptide and islet amyloid polypeptide (IAPP) is implicated in the pathogenesis of Alzheimer’s disease (AD) and Type 2 diabetes (T2D), respectively. Increasing evidence, particularly the co-deposition of Aβ
Kenana Al Adem +12 more
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