Results 41 to 50 of about 13,087 (187)

IAPP Amyloid Aggregation and IAPP-Associated Toxicity Mitigation [PDF]

, 2018
Human islet amyloid polypeptide (IAPP, a.k.a. amylin) is a 37-residue peptide hormone co-synthesized and co-secreted with insulin by pancreatic β-cells for glycemic control.
Ge, Xinwei
core  

The β-cell assassin: IAPP cytotoxicity [PDF]

, 2017
Islet amyloid polypeptide (IAPP) forms cytotoxic oligomers and amyloid fibrils in islets in type 2 diabetes (T2DM). The causal factors for amyloid formation are largely unknown.
Clark, A, Daniel Raleigh, Anne Clark, Hastoy, Benoit, Clark, Anne, Benoît Hastoy, Hastoy, B, Xiaoxue Zhang, Zhang, X, Raleigh, D   +9 more
core   +2 more sources

Analysis of Baboon IAPP provides insight into amyloidogenicity and cytotoxicity of human IAPP [PDF]

, 2020
The polypeptide hormone islet amyloid polypeptide (IAPP) forms islet amyloid in type 2 diabetes, a process which contributes to pancreatic β-cell dysfunction and death.
Thalassinos, Konstantinos, Zhyvoloup, Alexander, Ridgway, Zachary, Lee, Kyung-Hoon, Abedini, Andisheh, Wong, Amy, Eldrid, Charles, Eldrid-Otterburn, Charles; id_orcid, Raleigh, Daniel P., Hannaberry, Eleni, Abedini, Andidesh   +10 more
core   +1 more source

Image1_Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide.pdf [PDF]

, 2023
Insulin resistance is the major risk factor for Type 2 diabetes (T2D). In vulnerable individuals, insulin resistance induces a progressive loss of insulin secretion with islet pathology revealing a partial deficit of beta cells and islet amyloid derived ...
Tatyana Gurlo (74077), Richard G. Lee (14569934), Peter C. Butler (14569937), Thazha P. Prakash (10814), Zhongying Wang (1702927), Maani Archang (14569925), Elaine Pirie (5904584), Madeline Rosenberger (14569931), Lina Pei (14569928)   +8 more
core   +1 more source

Assessing Mesoscale Heterogeneities in Hard Carbon Electrodes Through Deep Learning‐Assisted FIB‐SEM Characterization, Manufacturing and Electrochemical Modeling

Advanced Energy Materials, EarlyView.
A combination of discrete and finite element method models for the current collector deformation and electrochemical performance analysis, respectively. The models are calibrated and validated with electrochemical and imaging data of hard carbon electrodes. These electrodes were manufactured with different parameters (slurry solid contents of 35 and 40
Soorya Saravanan, Imelda Cardenas‐Sierra, Pei Sun, Hari Raj, Daniele Duranti, Mahnoor Nafees, Edoardo Rossi, Marco Sebastiani, Paul Vigneaux, Martin Petit, Maxime Moreaud, Francisco Fernandez, Alejandro A. Franco   +12 more
wiley   +1 more source

IAPP - oligomerisation levels in plasma of people with type 2 diabetes

Scientific Reports
Islet amyloid polypeptide (IAPP) is co-secreted with insulin from pancreatic ß-cells. Its oligomerisation is regarded as disease driving force in type 2 diabetes (T2D) pathology. Up to now, IAPP oligomers have been detected in affected tissues.
Fabian Rehn, Victoria Kraemer-Schulien, Tuyen Bujnicki, Oliver Bannach, Diethelm Tschoepe, Bernd Stratmann, Dieter Willbold   +6 more
doaj   +1 more source

Myricetin Inhibits Islet Amyloid Polypeptide (IAPP) Aggregation and Rescues Living Mammalian Cells from IAPP Toxicity [PDF]

, 2012
The aggregation of the amyloidogenic polypeptide IAPP (Islet Amyloid Polypeptide, amylin) is believed to play a direct role in the death of pancreatic β-islet cells in type II diabetes. Preventing the initial aggregation event of IAPP is one strategy for
Fox, Ayano, Zelus, Casey, Moffet, David A., Nogaj, Luiza A., Calciano, Anastasia, Faridian, Bianca S.   +5 more
core   +1 more source

IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes. [PDF]

, 2022
Aims/hypothesisType 2 diabetes is characterised by islet amyloid and toxic oligomers of islet amyloid polypeptide (IAPP). We posed the questions, (1) does IAPP toxicity induce an islet response comparable to that in humans with type 2 diabetes, and if so,
Gao, Fuying, Wang, Qing, Mawla, Alex M, Gurlo, Tatyana, Furterer, Allison, Yang, Xia, Blencowe, Montgomery, Huising, Mark O, Coppola, Giovanni, Butler, Peter C, Nomoto, Hiroshi, Pei, Lina, Rosenberger, Madeline   +12 more
core   +1 more source

Cultivating Circularity: Harnessing Industry 4.0 and Stakeholder Engagement for a Sustainable Agrifood Future in Brazil

Business Strategy and the Environment, EarlyView.
ABSTRACT This study analyzed Industry 4.0 (I4.0) technology applications in agribusiness and the role of strategic stakeholders, engagement methods, and other critical aspects data sharing, confidentiality, integrity, decision‐making, and sector‐specific requirements in promoting circularity.
Simone Sehnem, Lucila M. S. Campos, Tais Provensi, Charbel Jose Chiappetta Jabbour   +3 more
wiley   +1 more source

Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes

Frontiers in Endocrinology, 2022
IntroductionDiabetes is one of the major metabolic diseases worldwide. Despite being a complex systemic pathology, the aggregation and deposition of Islet Amyloid Polypeptide (IAPP), or amylin, is a recognized histopathological marker of the disease ...
Ana F. Raimundo, Ana F. Raimundo, Ana F. Raimundo, Sofia Ferreira, Sofia Ferreira, Sofia Ferreira, Vânia Pobre, Mafalda Lopes-da-Silva, José A. Brito, Daniel J. V. A. dos Santos, Nuno Saraiva, Cláudia N. dos Santos, Cláudia N. dos Santos, Regina Menezes, Regina Menezes, Regina Menezes   +15 more
doaj   +1 more source