Results 61 to 70 of about 13,087 (187)

IDENTIFICATION OF NATURALLY OCCURING IAPP PEPTIDES CAPABLE OF INHIBITING FORMATION OF TOXIC HUMAN IAPP AMYLOID [PDF]

, 2019
The loss of insulin-producing β-cells and the overall progression of type 2 diabetes appears to be linked to the formation of toxic human IAPP (hIAPP, Islet Amyloid Polypeptide, amylin) amyloid.
Distor, Lianlen Joy Go
core  

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, EarlyView.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Altered immunoreactivity of islet amyloid polypeptide (IAPP) may reflect major modifications of the IAPP molecule in amyloidogenesis [PDF]

, 1997
We have developed a mouse monoclonal antibody against rat/mouse islet amyloid polypeptide (IAPP). The antibody recognises an epitope in the N-terminal part of the molecule, which is conserved between different species.
Ma, Zhi,, Li, Z.-C.,, Westermark, P.,, Westermark, Gunilla,, Engström, U.,   +4 more
core   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Organic narrowband near-infrared photodetectors based on intermolecular charge-transfer absorption

Nature Communications, 2017
Interfaces of organic donor-acceptor blends provide intermolecular charge-transfer states with red-shifted but weak absorption. By introducing an optical micro-cavity; Siegmundet al., enhance their photoresponse to achieve narrowband NIR photodetection ...
Bernhard Siegmund, Andreas Mischok, Johannes Benduhn, Olaf Zeika, Sascha Ullbrich, Frederik Nehm, Matthias Böhm, Donato Spoltore, Hartmut Fröb, Christian Körner, Karl Leo, Koen Vandewal   +11 more
doaj   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides

Journal of Diabetes Research, 2015
Pancreatic islets in type 2 diabetes mellitus (T2DM) patients are characterized by reduced β-cells mass and diffuse extracellular amyloidosis.
Marianna Flora Tomasello, Alessandro Sinopoli, Giuseppe Pappalardo   +2 more
doaj   +1 more source

Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations. [PDF]

PLoS ONE, 2013
Type 2 diabetes (T2D) is a complex disease characterized by beta cell dysfunctions. Islet amyloid polypeptide (IAPP) is highly conserved and co-secreted with insulin with over 40% of autopsy cases of T2D showing islet amyloid formation due to IAPP ...
Vincent Kwok Lim Lam, Ronald Ching Wan Ma, Heung Man Lee, Cheng Hu, Kyong Soo Park, Hiroto Furuta, Ying Wang, Claudia Ha Ting Tam, Xueling Sim, Daniel Peng-Keat Ng, Jianjun Liu, Tien-Yin Wong, E Shyong Tai, Andrew P Morris, DIAGRAM Consortium, Nelson Leung Sang Tang, Jean Woo, Ping Chung Leung, Alice Pik Shan Kong, Risa Ozaki, Wei Ping Jia, Hong Kyu Lee, Kishio Nanjo, Gang Xu, Maggie Chor Yin Ng, Wing-Yee So, Juliana Chung Ngor Chan   +26 more
doaj   +1 more source

Transcriptional regulation of the IAPP gene in pancreatic beta-cells [PDF]

, 2004
Islet amyloid polypeptide (IAPP or amylin) is co-secreted with insulin from the pancreatic β-cells. Transcription of the IAPP gene is controlled by a complex promoter region, spanning from −2798 to +450 relative to the transcriptional start site.
Campbell, S.C., Macfarlane, Wendy; id_orcid, Shepherd, L.M.A.   +2 more
core   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, Volume 30, Issue 4, Page 536-543, August 2026.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source