Results 81 to 90 of about 13,087 (187)

The role of amylin, a gut-brain axis hormone, in metabolic and neurological disorders. [PDF]

FASEB Bioadv
Amylin, also known as islet amyloid polypeptide (IAPP), is a pancreatic β‐cell peptide hormone involved in satiation and control food intake. It is also produced in smaller quantities by neurons, the gastrointestinal tract, and spinal ganglia.
Muhammad T, Pastore SF, Good K, Yu WH, Vincent JB.   +4 more
europepmc   +2 more sources

Curing Perovskite Photovoltaics With Organic Functional Molecules: Progress, Mechanism, and Prospect

Interdisciplinary Materials, Volume 5, Issue 4, Page 551-572, July 2026.
Leveraging the advantages of precision‐targeted design, excellent chemical stability, diverse geometric configuration, and economic viability, the application of medicinally derived organic functional molecules can accelerate curing multiple problems in perovskite photovoltaics, not only promoting synergistic effects among the functional layers, but ...
Jin Wang, Weihui Bi, Jun Lv, Mengyuan Li, Yanjun Fang, Yingying Xu, Po‐Chuan Yang, Shen Xing, Huichuan Pei, Yufei Zhong   +9 more
wiley   +1 more source

Cell-to-cell transmission of IAPP aggregates in T2DM induces neuronal death by triggering oxidative stress and ferroptosis

Neurobiology of Disease
Type 2 diabetes mellitus (T2DM) is associated with an elevated risk of neurodegenerative diseases, yet the underlying mechanisms remain elusive. A hallmark feature of T2DM is the amyloid deposition of islet amyloid polypeptide (IAPP) in the pancreas ...
Honglin Zheng, Yapei Yuan, Na Zhang, Hang Zhang, Suying Duan, Chenyang Liu, Yaochong Zhang, Qiang Li, Han Liu, Mibo Tang, Haiyang Luo, Yuming Xu   +11 more
doaj   +1 more source

Lipid Dynamics in the Amyloid Cascade Hypothesis: Evaluating the Biological Relevance of In Vitro Models

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle, Fabio Lolicato, Carmelo Tempra, Martina Pannuzzo, Michele F. M. Sciacca, Danilo Milardi, Carmelo La Rosa   +6 more
wiley   +1 more source

Impact of genetically improved fish species and technology on selected hatchery and fish production in Bangladesh

International Journal of Agricultural Research, Innovation and Technology, 2017
The study was carried out in IAPP commanding areas from July to September 2015. A total of 8 hatchery and 240 farmers were selected for this study from Rangpur and Barisal region.
MS Islam
doaj   +1 more source

Amyloidogenicity of naturally occurring full-length animal IAPP variants [PDF]

, 2019
Aim: To identify naturally occurring variants of IAPP capable of inhibiting the aggregation of human IAPP and protecting living cells from the toxic effects of human IAPP.
Olivares, Eileen, Chang, Kevin, Jauregui, Betssy L., Njoo, Edward, Tun, Angela, Moffet, David A., Nogaj, Luiza A., Oakes, Alissa, Pilcher, Shannon, Torres, Jaris, Ledesma Monjaraz, Litza I., Nguyen, Viviane, Rinauro, Dillon J., Palato, Larry M., Munoz, Crystabel, Nossiff, Olivia H., Menefee, Kate Alexandra, Shapiro, Sarah, Lamba, Arleen   +18 more
core  

Comparison of human Aβ, human IAPP and rodent IAPP peptide sequences. [PDF]

, 2016
(A) The amino acid sequence of human Aβ (10–42); the described “theta” site (θ) is indicated by an arrow between phenylalanine residues 19 and 20 (in red).
Jonitha Gardner (328549), Helene Baribault (328546), Ping Cao (564151), Li Miao (734548), Trace Tsuruda (2011873), Yang Li (7082), Linda Huang (2141800), Kui Chen (157443), Xiaosu Wu (756219), Jed Wiltzius (2141794), Ryan D. White (1656982), Oliver Homann (2141806), Harvey Yamane (559007), Ingrid C. Rulifson (2141809), Kim Samayoa (2141803), David Kopecky (2141812), Tim Carlson (2141797)   +16 more
core   +1 more source

Lipid accelerating the fibril of islet amyloid polypeptide aggravated the pancreatic islet injury in vitro and in vivo

Lipids in Health and Disease, 2018
Background The fibrillation of islet amyloid polypeptide (IAPP) triggered the amyloid deposition, then enhanced the loss of the pancreatic islet mass. However, it is not clear what factor is the determinant in development of the fibril formation. The aim
Xiao-Dan Mo, Li-Ping Gao, Qing-Jun Wang, Jie Yin, Yu-Hong Jing   +4 more
doaj   +1 more source

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

Journal of Diabetes Research, 2016
The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose homeostasis but aggregates to form islet amyloid in type-2 diabetes. Islet amyloid formation contributes to β-cell dysfunction and death in the disease and to the failure of ...
Rehana Akter, Ping Cao, Harris Noor, Zachary Ridgway, Ling-Hsien Tu, Hui Wang, Amy G. Wong, Xiaoxue Zhang, Andisheh Abedini, Ann Marie Schmidt, Daniel P. Raleigh   +10 more
doaj   +1 more source

Okinawa-Based Nordic Diet Decreases Plasma Levels of IAPP and IgA against IAPP Oligomers in Type 2 Diabetes Patients [PDF]

Pancreas-derived islet amyloid polypeptide (IAPP) aggregates and deposits in the pancreas and periphery of Type 2 Diabetes (T2D) patients, contributing to diabetic complications.
Bodil Roth, Malin Wennström, Wennström, Malin, Dovilė Pocevičiūtė, Bodil Ohlsson, Pocevičiūtė, Dovilė, Roth, Bodil, Ohlsson, Bodil   +7 more
core   +1 more source