Results 91 to 100 of about 13,087 (187)

Star polymers reduce IAPP toxicity via accelerated amyloid aggregation [PDF]

, 2017
Protein aggregation into amyloid fibrils is a ubiquitous phenomenon across the spectrum of neurodegenerative disorders and type 2 diabetes. A common strategy against amyloidogenesis is to minimize the populations of toxic oligomers and protofibrils by ...
Esteban N. Gurzov, Whittaker, Michael R, Whittaker, MR, Quinn, JF, Ke , Pu Chun, Ke, Pu Chun, Davis, Thomas P, Whittaker, Michael R., Ding, Feng, Sani, Marc-Antonie, Gurov, Esteban, Thomas P. Davis, John F. Quinn, Pilkington, Emily H., Quinn, John, Ge, X, Wang, Bo, Pilkington, EH, Gurzov, Esteban Nicolas, Aleksandr Kakinen, Pu Chun Ke, Xinwei Ge, Wang, Miaovi, Bo Wang, Feng Ding, Marc-Antonie Sani, Wang, B, Quinn, John F., Ge, Xinwei, Davis, Thomas P., Quinn, John JF, Lai, M, Wang, M, Pilkington, Emily H, Sani, Mark-Antoine, Kakinen, A, Stanley, William J, Wang, Miaoyi, Emily H. Pilkington, Lai, May, Ding, F, May Lai, Davis, TP, Kakinen, Aleksandr, William J. Stanley, Miaoyi Wang, Stanley, WJ, Whittaker, Michael MR, Gurzov, Esteban N., Stanley, William J., Michael R. Whittaker, Gurzov, EN, Sani, MA, Ke, PC   +53 more
core   +1 more source

IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation

International Journal of Immunopathology and Pharmacology, 2018
Recent findings revealed that type 2 diabetes mellitus (T2D) is a chronic inflammatory disease and an islet amyloid polypeptide (IAPP)/amylin, is deposited within pancreatic islets.
Shinnosuke Morikawa, Naoe Kaneko, Chikara Okumura, Haruka Taguchi, Mie Kurata, Toshihiro Yamamoto, Haruhiko Osawa, Ayaka Nakanishi, Tamotsu Zako, Junya Masumoto   +9 more
doaj   +1 more source

Physical and toxicological profiles of human IAPP amyloids and plaques [PDF]

, 2019
Although much has been learned about the fibrillization kinetics, structure and toxicity of amyloid proteins, the properties of amyloid fibrils beyond the saturation phase are often perceived as chemically and biologically inert, despite evidence ...
Ke , Pu Chun, Kakinen, Aleksandr, Faridi, Ava, Faridi, Pouya, Pilkington, Emily H., Purcell, Anthony W., Zhou, Ruhong, Davis, Thomas P., Davis, Thomas P, Ke, Pu Chun, Sun, Yunxiang, Purcell, Anthony W, Pilkington, Emily H, Ding, Feng, Lin, Sijie, Javed, Ibrahim   +15 more
core   +1 more source

IAPP and type 1 diabetes: implications for immunity, metabolism and islet transplants [PDF]

, 2018
Islet amyloid polypeptide (IAPP), the main component of islet amyloid in type 2 diabetes and islet transplants, is now recognized as a contributor to beta cell dysfunction.
C Bruce Verchere, Heather C Denroche
core   +1 more source

Identification and charaeterization of IAPP-derived inhibitors of cytotoxic self-assembly and amyloidogenesis of islet amyloid polypeptide (IAPP) and beta-amyloid peptide (A beta) [PDF]

, 2008
Protein aggregation into cytotoxic oligomers and fibrils in vivo is linked to cell degeneration and the pathogenesis of more than 25 uncurable diseases, which are often called amyloid diseases, while the high aggregation propensity and insolubility of ...
Yan, Li-Mei
core   +2 more sources

Bistable organic electrochemical transistors: enthalpy vs. entropy

Nature Communications
Organic electrochemical transistors (OECTs) underpin a range of emerging technologies, from bioelectronics to neuromorphic computing, owing to their unique coupling of electronic and ionic charge carriers.
Lukas M. Bongartz, Richard Kantelberg, Tommy Meier, Raik Hoffmann, Christian Matthus, Anton Weissbach, Matteo Cucchi, Hans Kleemann, Karl Leo   +8 more
doaj   +1 more source

Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus

Clinical Interventions in Aging, 2015
Hye Rin Jeong, Seong Soo A AnDepartment of Bionano Technology, Gachon Medical Research Institute, Gachon University, Gyeonggi-do, Republic of KoreaAbstract: Human islet amyloid polypeptide (h-IAPP) is a peptide hormone that is synthesized and cosecreted ...
Jeong HR, An SSA
doaj  

RAGE binds preamyloid IAPP intermediates and mediates pancreatic beta cell proteotoxicity [PDF]

, 2018
Islet amyloidosis is characterized by the aberrant accumulation of islet amyloid polypeptide (IAPP) in pancreatic islets, resulting in β cell toxicity, which exacerbates type 2 diabetes and islet transplant failure. It is not fully clear how IAPP induces
Abedini, A, Derk, J, Schmidt, AM, Rosario, R, Li, H, Raleigh, DP, Song, F, Plesner, A, Patil, SA, Cao, P, Koh, H, He, M, Lonier, J, Zhang, J   +13 more
core  

Life‐Cycle Assessment of Printed Electronic Components ‐ Case Study for Organic Electrochemical Transistors

Advanced Electronic Materials
To ensure sustainable progress, future electronics must prioritize both performance and environmental impact, explaining the interest in flexible and printed electronics.
Laura Teuerle, Tommy Meier, Klara Hänisch, Finn Jaekel, Yeohoon Yoon, Andreas Wendel, Hans Kleemann   +6 more
doaj   +1 more source

An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell-derived insulin producing cells

Molecular Metabolism
Objective: Human embryonic stem cell (hESC; SC)-derived pancreatic β cells can be used to study diabetes pathologies and develop cell replacement therapies.
Carmen L. Bayly, Xiao-Qing Dai, Cuilan Nian, Paul C. Orban, C. Bruce Verchere, Patrick E. MacDonald, Francis C. Lynn   +6 more
doaj   +1 more source