Results 71 to 80 of about 13,087 (187)
eLife, 2016 Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and biological measurements, we define the toxic species produced during IAPP ...
Andisheh Abedini +15 more
doaj +1 more source
The effect of inositols on IAPP amyloid formation depends on their stereochemistry. [PDF]
, 2014 (A) Kinetic curves of amyloid formation by IAPP and mixtures of IAPP with inositol stereoisomers as monitored by thioflavin-T fluorescence assays. Black, IAPP; red, IAPP + myo-inositol; green, IAPP + epi-inositol; purple, IAPP + scyllo-inositol; blue ...
Hui Wang (30400) +1 more
core +1 more source
QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study
Advanced Science, Volume 13, Issue 37, 3 July 2026.The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda +8 more
wiley +1 more source
Regulation of IAPP transcription by spliced XBP1 [PDF]
, 2019 In Alzheimer’s disease (AD), progressive memory loss and cognitive decline have been associated with the presence of extracellular amyloid plaques in the brain.
Lin, Susan
core
Inhibition of toxic IAPP amyloid by extracts of common fruits [PDF]
, 2015 The aggregation of the 37-amino acid polypeptide islet amyloid polypeptide (IAPP, amylin), as either insoluble amyloid or as small oligomers, appears to play a direct role in the death of pancreatic β-islet cells in type 2 diabetes.
Moffet, David
core +4 more sources
Aggregate, Volume 7, Issue 7, July 2026.Distinct from traditional single‐function regulation strategy, both multimolecule synergistic regulation and all‐in‐one integration regulation strategies can achieve multifunctional regulation. This paper presents the research progress, advantages, and limitations, as well as applicable scenarios of the two strategies, offering prospects for the future
Jin Wang +7 more
wiley +1 more source
Electrical Pumping of Perovskite Diodes: Toward Stimulated Emission
Advanced Science, 2021 The success of metal halide perovskites in photovoltaic and light‐emitting diodes (LEDs) motivates their application as a solid‐state thin‐film laser. Various perovskites have shown optically pumped stimulated emission of lasing and amplified spontaneous
Changsoon Cho +8 more
doaj +1 more source
AIChE Journal, Volume 72, Issue 7, July 2026.Abstract A multipore, multiphase, continuum model is assembled for the first time for room temperature sodium–sulfur (RT Na–S) batteries, with Na+ ion transport and redox reactions in the liquid electrolyte phase and semisolid phase of precipitates softened by the electrolyte solvent, as guided by molecular dynamics simulations in this study ...
Hakeem A. Adeoye +3 more
wiley +1 more source
Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP [PDF]
, 2000 Background: Several mouse strains expressing human islet amyloid polypeptide (IAPP) have been created to study development of islet amyloid and its impact on islet cell function.
Westermark, P, +3 more
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ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 4, July 2026.This study synthesizes monodisperse oxide nanoparticles with abundant ionic vacancies encapsulated in 2D porous carbon sheets via pyrolysis of a high‐entropy precursor, constructing a cross‐scale catalytic interface. It enables Li‐S batteries with a high capacity of 761 mAh g−1 at 3 C and retains 80.44% capacity after 1000 cycles at 1 C.
Zeyu Xue +14 more
wiley +1 more source