Results 51 to 60 of about 13,087 (187)
Toxic human IAPP oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent human IAPP induced beta-cell apoptosis in human IAPP transgenic mice [PDF]
, 2010 [[abstract]]OBJECTIVE—Islets in type 2 diabetes are characterized by a deficit in β-cells, increased β-cell apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP).
LIN CY; Gurlo T; Kayed R; Butler AE; Haataja L; Glabe CG; Butler PC
core +1 more source
Islet amyloid polypeptide (IAPP) in patients with neuroendocrine tumours [PDF]
, 1995 Although IAPP was first discovered and isolated from amyloid deposits in an endocrine pancreatic tumour (EPT), surprisingly few reports have investigated the potential use of IAPP as a marker for neuroendocrine tumour growth.
Eriksson, Barbro, +11 more
core +1 more source
Utvärdering av anti-IAPP/pro-IAPP-reaktivitet [PDF]
Islet amyloid polypeptide (IAPP) aggregation in the pancreatic islet damages the beta cells and induces apoptosis via caspase-3 activations, a common finding in type 2 diabetes.
Hameed, Fayez
core +2 more sources
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman +3 more
wiley +1 more source
Vaccines, 2020 Type 2 diabetes mellitus (T2DM) is a chronic progressive disease characterized by insulin resistance and insufficient insulin secretion to maintain normoglycemia.
Elisa S. Roesti +9 more
doaj +1 more source
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism [PDF]
, 2017 Although a large proportion of patients with type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown.
Gonzalez, Cesar +23 more
core +3 more sources
Developing an evidence‐based model to implement co‐governance
Australian Journal of Public Administration, EarlyView.Abstract Governments are seeking innovative ways to address complex policy issues in increasingly fragmented and fiscally constrained service contexts. Co‐governance is a relatively new mechanism for facilitating collective decision‐making between government and other stakeholders. Effective co‐governance can be difficult to establish and resource‐ and
Shona Marie Bates +4 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2022 The islet amyloid polypeptide (IAPP) is a 37-residue aggregation-prone peptide hormone whose deposition as insoluble fibrils in the islets of Langerhans is associated with type II diabetes.
Mathilde Fortier +13 more
doaj +1 more source
Amylin analogues as a novel perspective in anti‐obesity therapy
British Journal of Pharmacology, EarlyView.Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley +1 more source
Neural Regeneration Research, 2021 Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions worldwide. Due to population ageing, the incidence of AD is increasing. AD patients develop cognitive decline and dementia, features for which is known, requiring permanent ...
Sofia Ferreira +3 more
doaj +1 more source